ESCO2

 

Full name: establishment of sister chromatid cohesion N-acetyltransferase 2 Alias Symbol: EFO2
Type: protein-coding gene Cytoband: 8p21.1
Entrez ID: 157570 HGNC ID: HGNC:27230 Ensembl Gene: ENSG00000171320 OMIM ID: 609353
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ESCO2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ESCO2 157570 235588_at 0.7689 0.0316
GSE26886 ESCO2 157570 235588_at 0.1560 0.4891
GSE45670 ESCO2 157570 235588_at 0.7156 0.0079
GSE53622 ESCO2 157570 102985 1.5429 0.0000
GSE53624 ESCO2 157570 102985 1.6050 0.0000
GSE63941 ESCO2 157570 235588_at 2.8523 0.0000
GSE77861 ESCO2 157570 235588_at 0.2449 0.1454
GSE97050 ESCO2 157570 A_33_P3326210 2.1372 0.1316
SRP007169 ESCO2 157570 RNAseq 1.8937 0.0006
SRP008496 ESCO2 157570 RNAseq 1.6131 0.0002
SRP064894 ESCO2 157570 RNAseq 1.0315 0.0007
SRP133303 ESCO2 157570 RNAseq 0.9630 0.0009
SRP159526 ESCO2 157570 RNAseq 1.1417 0.0005
SRP193095 ESCO2 157570 RNAseq 0.3607 0.0600
SRP219564 ESCO2 157570 RNAseq 1.5036 0.0513
TCGA ESCO2 157570 RNAseq 1.0512 0.0000

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by ESCO2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ESCO2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ESCO2 157570 6 10 14
GSE20123 ESCO2 157570 6 10 14
GSE43470 ESCO2 157570 4 7 32
GSE46452 ESCO2 157570 13 13 33
GSE47630 ESCO2 157570 10 8 22
GSE54993 ESCO2 157570 2 15 53
GSE54994 ESCO2 157570 10 15 28
GSE60625 ESCO2 157570 3 0 8
GSE74703 ESCO2 157570 4 6 26
GSE74704 ESCO2 157570 4 7 9
TCGA ESCO2 157570 16 43 37

Total number of gains: 78; Total number of losses: 134; Total Number of normals: 276.  

 

Somatic mutations of ESCO2:

 

Generating mutation plots.

 

Highly correlated genes for ESCO2:

 

Showing top 20/1403 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ESCO2BIRC50.835212707
ESCO2MKI670.813586606
ESCO2TPX20.811937706
ESCO2NEK20.811369707
ESCO2STIL0.808648606
ESCO2KIF20A0.806623606
ESCO2CDK10.805098606
ESCO2CDCA80.804824606
ESCO2PBK0.804691808
ESCO2CEP850.79795505
ESCO2GINS10.792275707
ESCO2TRIP130.791001707
ESCO2UBE2C0.790105807
ESCO2CHD70.789028303
ESCO2CENPF0.787807707
ESCO2GMNN0.786659707
ESCO2CDT10.785891707
ESCO2IQGAP30.784893505
ESCO2CDCA20.778121605
ESCO2CCNB20.777681706

For details and further investigation, click here