| Full name: thioredoxin domain containing 12 | Alias Symbol: TLP19|ERP18|ERP19|hAG-1|AGR1|PDIA16 | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 51060 | HGNC ID: HGNC:24626 | Ensembl Gene: ENSG00000117862 | OMIM ID: 609448 |
| Drug and gene relationship at DGIdb | |||
Expression of TXNDC12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TXNDC12 | 51060 | 223017_at | 0.6495 | 0.1459 | |
| GSE26886 | TXNDC12 | 51060 | 223017_at | 0.6470 | 0.0002 | |
| GSE45670 | TXNDC12 | 51060 | 223017_at | 0.6191 | 0.0001 | |
| GSE53622 | TXNDC12 | 51060 | 93483 | 0.9054 | 0.0000 | |
| GSE53624 | TXNDC12 | 51060 | 93483 | 0.8064 | 0.0000 | |
| GSE63941 | TXNDC12 | 51060 | 223017_at | 0.3456 | 0.1477 | |
| GSE77861 | TXNDC12 | 51060 | 223017_at | 0.5953 | 0.0621 | |
| GSE97050 | TXNDC12 | 51060 | A_23_P200199 | 0.8682 | 0.0885 | |
| SRP007169 | TXNDC12 | 51060 | RNAseq | 0.8254 | 0.0262 | |
| SRP008496 | TXNDC12 | 51060 | RNAseq | 0.7807 | 0.0016 | |
| SRP064894 | TXNDC12 | 51060 | RNAseq | 1.0242 | 0.0000 | |
| SRP133303 | TXNDC12 | 51060 | RNAseq | 1.0262 | 0.0000 | |
| SRP159526 | TXNDC12 | 51060 | RNAseq | 0.9862 | 0.0007 | |
| SRP193095 | TXNDC12 | 51060 | RNAseq | 0.4858 | 0.0003 | |
| SRP219564 | TXNDC12 | 51060 | RNAseq | 0.9690 | 0.0134 | |
| TCGA | TXNDC12 | 51060 | RNAseq | 0.1723 | 0.0003 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TXNDC12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TXNDC12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TXNDC12 | 51060 | 3 | 4 | 23 | |
| GSE20123 | TXNDC12 | 51060 | 3 | 3 | 24 | |
| GSE43470 | TXNDC12 | 51060 | 5 | 4 | 34 | |
| GSE46452 | TXNDC12 | 51060 | 2 | 1 | 56 | |
| GSE47630 | TXNDC12 | 51060 | 8 | 4 | 28 | |
| GSE54993 | TXNDC12 | 51060 | 0 | 1 | 69 | |
| GSE54994 | TXNDC12 | 51060 | 11 | 2 | 40 | |
| GSE60625 | TXNDC12 | 51060 | 0 | 0 | 11 | |
| GSE74703 | TXNDC12 | 51060 | 4 | 2 | 30 | |
| GSE74704 | TXNDC12 | 51060 | 2 | 0 | 18 | |
| TCGA | TXNDC12 | 51060 | 10 | 18 | 68 |
Total number of gains: 48; Total number of losses: 39; Total Number of normals: 401.
Somatic mutations of TXNDC12:
Generating mutation plots.
Highly correlated genes for TXNDC12:
Showing top 20/1726 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TXNDC12 | LRRC8D | 0.771501 | 7 | 0 | 7 |
| TXNDC12 | CKS1B | 0.768333 | 8 | 0 | 8 |
| TXNDC12 | CDK4 | 0.762153 | 7 | 0 | 7 |
| TXNDC12 | SNAI2 | 0.760632 | 3 | 0 | 3 |
| TXNDC12 | PDIA5 | 0.748016 | 3 | 0 | 3 |
| TXNDC12 | DLGAP5 | 0.745976 | 7 | 0 | 6 |
| TXNDC12 | RNASEH2A | 0.741062 | 8 | 0 | 7 |
| TXNDC12 | CDCA8 | 0.736975 | 7 | 0 | 7 |
| TXNDC12 | CDCA5 | 0.736871 | 6 | 0 | 6 |
| TXNDC12 | PSMB2 | 0.736487 | 7 | 0 | 7 |
| TXNDC12 | KIF2C | 0.736372 | 8 | 0 | 8 |
| TXNDC12 | STARD7 | 0.735042 | 5 | 0 | 5 |
| TXNDC12 | CTHRC1 | 0.734397 | 7 | 0 | 7 |
| TXNDC12 | CDK5 | 0.733359 | 4 | 0 | 4 |
| TXNDC12 | LAPTM4B | 0.729036 | 6 | 0 | 6 |
| TXNDC12 | BAX | 0.728073 | 3 | 0 | 3 |
| TXNDC12 | TAF1A | 0.727397 | 7 | 0 | 7 |
| TXNDC12 | CDK1 | 0.726297 | 8 | 0 | 6 |
| TXNDC12 | NDC1 | 0.725949 | 7 | 0 | 7 |
| TXNDC12 | KIF23 | 0.723999 | 6 | 0 | 6 |
For details and further investigation, click here
