| Full name: thyroglobulin | Alias Symbol: TGN|AITD3 | ||
| Type: protein-coding gene | Cytoband: 8q24.22 | ||
| Entrez ID: 7038 | HGNC ID: HGNC:11764 | Ensembl Gene: ENSG00000042832 | OMIM ID: 188450 |
| Drug and gene relationship at DGIdb | |||
TG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04918 | Thyroid hormone synthesis |
Expression of TG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TG | 7038 | 203673_at | 0.4831 | 0.3489 | |
| GSE20347 | TG | 7038 | 203673_at | 0.0402 | 0.7194 | |
| GSE23400 | TG | 7038 | 203673_at | -0.1554 | 0.0006 | |
| GSE26886 | TG | 7038 | 203673_at | 0.7765 | 0.0080 | |
| GSE29001 | TG | 7038 | 203673_at | -0.1534 | 0.3025 | |
| GSE38129 | TG | 7038 | 203673_at | 0.0901 | 0.5513 | |
| GSE45670 | TG | 7038 | 203673_at | 0.1807 | 0.1322 | |
| GSE53622 | TG | 7038 | 162664 | 0.4278 | 0.0019 | |
| GSE53624 | TG | 7038 | 162664 | 0.7272 | 0.0000 | |
| GSE63941 | TG | 7038 | 203673_at | 0.3242 | 0.2570 | |
| GSE77861 | TG | 7038 | 203673_at | -0.1109 | 0.2219 | |
| GSE97050 | TG | 7038 | A_23_P32454 | -0.0727 | 0.8138 | |
| SRP133303 | TG | 7038 | RNAseq | 0.1214 | 0.7376 | |
| SRP159526 | TG | 7038 | RNAseq | 0.7370 | 0.2996 | |
| SRP193095 | TG | 7038 | RNAseq | 1.2984 | 0.0010 | |
| TCGA | TG | 7038 | RNAseq | 1.4526 | 0.0027 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TG | 7038 | 18 | 0 | 12 | |
| GSE20123 | TG | 7038 | 18 | 0 | 12 | |
| GSE43470 | TG | 7038 | 23 | 1 | 19 | |
| GSE46452 | TG | 7038 | 27 | 0 | 32 | |
| GSE47630 | TG | 7038 | 24 | 0 | 16 | |
| GSE54993 | TG | 7038 | 0 | 24 | 46 | |
| GSE54994 | TG | 7038 | 39 | 1 | 13 | |
| GSE60625 | TG | 7038 | 0 | 7 | 4 | |
| GSE74703 | TG | 7038 | 20 | 0 | 16 | |
| GSE74704 | TG | 7038 | 12 | 0 | 8 | |
| TCGA | TG | 7038 | 66 | 2 | 28 |
Total number of gains: 247; Total number of losses: 35; Total Number of normals: 206.
Somatic mutations of TG:
Generating mutation plots.
Highly correlated genes for TG:
Showing top 20/368 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TG | MED12 | 0.765935 | 3 | 0 | 3 |
| TG | ULK1 | 0.759423 | 3 | 0 | 3 |
| TG | RIMKLB | 0.7378 | 3 | 0 | 3 |
| TG | KLHL33 | 0.736861 | 3 | 0 | 3 |
| TG | HELZ | 0.733025 | 3 | 0 | 3 |
| TG | ALKBH6 | 0.727141 | 3 | 0 | 3 |
| TG | ZBED1 | 0.719586 | 3 | 0 | 3 |
| TG | ALG11 | 0.714686 | 3 | 0 | 3 |
| TG | TSHR | 0.708066 | 4 | 0 | 4 |
| TG | ZNF251 | 0.705562 | 3 | 0 | 3 |
| TG | SSBP4 | 0.70462 | 3 | 0 | 3 |
| TG | TMEM63B | 0.699095 | 4 | 0 | 4 |
| TG | SLC26A5 | 0.696884 | 3 | 0 | 3 |
| TG | CHD7 | 0.694059 | 3 | 0 | 3 |
| TG | KRTAP10-9 | 0.694058 | 3 | 0 | 3 |
| TG | GYG2 | 0.693461 | 5 | 0 | 5 |
| TG | IGFL3 | 0.688187 | 3 | 0 | 3 |
| TG | SPEG | 0.683908 | 3 | 0 | 3 |
| TG | USP17L2 | 0.680472 | 3 | 0 | 3 |
| TG | WDR81 | 0.679382 | 3 | 0 | 3 |
For details and further investigation, click here
