| Full name: lymphocyte antigen 6 family member E | Alias Symbol: TSA-1|RIG-E|SCA-2 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 4061 | HGNC ID: HGNC:6727 | Ensembl Gene: ENSG00000160932 | OMIM ID: 601384 |
| Drug and gene relationship at DGIdb | |||
Expression of LY6E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LY6E | 4061 | 202145_at | 1.0949 | 0.3234 | |
| GSE20347 | LY6E | 4061 | 202145_at | 1.1102 | 0.0001 | |
| GSE23400 | LY6E | 4061 | 202145_at | 0.8650 | 0.0000 | |
| GSE26886 | LY6E | 4061 | 202145_at | 0.8678 | 0.0101 | |
| GSE29001 | LY6E | 4061 | 202145_at | 0.9048 | 0.0137 | |
| GSE38129 | LY6E | 4061 | 202145_at | 1.1187 | 0.0000 | |
| GSE45670 | LY6E | 4061 | 202145_at | 0.9179 | 0.0017 | |
| GSE53622 | LY6E | 4061 | 10442 | 0.5710 | 0.0000 | |
| GSE53624 | LY6E | 4061 | 10442 | 0.5249 | 0.0000 | |
| GSE63941 | LY6E | 4061 | 202145_at | 2.8489 | 0.0065 | |
| GSE77861 | LY6E | 4061 | 202145_at | 0.3240 | 0.3803 | |
| GSE97050 | LY6E | 4061 | A_24_P317762 | 1.1384 | 0.1316 | |
| SRP007169 | LY6E | 4061 | RNAseq | 0.6429 | 0.2801 | |
| SRP008496 | LY6E | 4061 | RNAseq | 0.7604 | 0.0236 | |
| SRP064894 | LY6E | 4061 | RNAseq | 1.9491 | 0.0000 | |
| SRP133303 | LY6E | 4061 | RNAseq | 0.8686 | 0.0003 | |
| SRP159526 | LY6E | 4061 | RNAseq | 0.1988 | 0.3850 | |
| SRP193095 | LY6E | 4061 | RNAseq | 1.3338 | 0.0000 | |
| SRP219564 | LY6E | 4061 | RNAseq | 1.3201 | 0.0301 | |
| TCGA | LY6E | 4061 | RNAseq | 0.5666 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by LY6E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LY6E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LY6E | 4061 | 16 | 1 | 13 | |
| GSE20123 | LY6E | 4061 | 17 | 1 | 12 | |
| GSE43470 | LY6E | 4061 | 17 | 2 | 24 | |
| GSE46452 | LY6E | 4061 | 27 | 0 | 32 | |
| GSE47630 | LY6E | 4061 | 23 | 1 | 16 | |
| GSE54993 | LY6E | 4061 | 0 | 25 | 45 | |
| GSE54994 | LY6E | 4061 | 39 | 1 | 13 | |
| GSE60625 | LY6E | 4061 | 3 | 4 | 4 | |
| GSE74703 | LY6E | 4061 | 15 | 1 | 20 | |
| GSE74704 | LY6E | 4061 | 10 | 0 | 10 | |
| TCGA | LY6E | 4061 | 64 | 2 | 30 |
Total number of gains: 231; Total number of losses: 38; Total Number of normals: 219.
Somatic mutations of LY6E:
Generating mutation plots.
Highly correlated genes for LY6E:
Showing top 20/1072 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LY6E | RNF213 | 0.815675 | 3 | 0 | 3 |
| LY6E | MED12 | 0.778452 | 3 | 0 | 3 |
| LY6E | CD80 | 0.742347 | 3 | 0 | 3 |
| LY6E | STAT2 | 0.734147 | 4 | 0 | 3 |
| LY6E | TRAPPC1 | 0.723248 | 3 | 0 | 3 |
| LY6E | SCML4 | 0.708512 | 3 | 0 | 3 |
| LY6E | ZFYVE27 | 0.706097 | 3 | 0 | 3 |
| LY6E | JMJD4 | 0.701776 | 3 | 0 | 3 |
| LY6E | MRPL38 | 0.697585 | 4 | 0 | 4 |
| LY6E | SLC39A3 | 0.692292 | 5 | 0 | 4 |
| LY6E | C8orf76 | 0.689795 | 3 | 0 | 3 |
| LY6E | CD40 | 0.688836 | 3 | 0 | 3 |
| LY6E | RPS15 | 0.688643 | 5 | 0 | 4 |
| LY6E | BIN2 | 0.683268 | 3 | 0 | 3 |
| LY6E | DEPDC5 | 0.677175 | 3 | 0 | 3 |
| LY6E | POLDIP3 | 0.675295 | 3 | 0 | 3 |
| LY6E | SPIRE2 | 0.671602 | 3 | 0 | 3 |
| LY6E | ZNF691 | 0.670854 | 4 | 0 | 4 |
| LY6E | GYS1 | 0.670444 | 3 | 0 | 3 |
| LY6E | USP21 | 0.66504 | 4 | 0 | 4 |
For details and further investigation, click here
