| Full name: Rho guanine nucleotide exchange factor 3 | Alias Symbol: STA3|XPLN|GEF3|DKFZP434F2429 | ||
| Type: protein-coding gene | Cytoband: 3p14.3 | ||
| Entrez ID: 50650 | HGNC ID: HGNC:683 | Ensembl Gene: ENSG00000163947 | OMIM ID: 612115 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGEF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF3 | 50650 | 218501_at | -0.5118 | 0.2291 | |
| GSE20347 | ARHGEF3 | 50650 | 218501_at | -0.9107 | 0.0003 | |
| GSE23400 | ARHGEF3 | 50650 | 218501_at | -0.5174 | 0.0000 | |
| GSE26886 | ARHGEF3 | 50650 | 218501_at | -0.9939 | 0.0007 | |
| GSE29001 | ARHGEF3 | 50650 | 218501_at | -0.7959 | 0.0642 | |
| GSE38129 | ARHGEF3 | 50650 | 218501_at | -0.7897 | 0.0000 | |
| GSE45670 | ARHGEF3 | 50650 | 218501_at | -0.2504 | 0.2042 | |
| GSE53622 | ARHGEF3 | 50650 | 111420 | -0.5990 | 0.0000 | |
| GSE53624 | ARHGEF3 | 50650 | 111420 | -0.8747 | 0.0000 | |
| GSE63941 | ARHGEF3 | 50650 | 218501_at | -0.7841 | 0.1354 | |
| GSE77861 | ARHGEF3 | 50650 | 218501_at | -0.8637 | 0.0213 | |
| GSE97050 | ARHGEF3 | 50650 | A_23_P143885 | -0.1179 | 0.8057 | |
| SRP007169 | ARHGEF3 | 50650 | RNAseq | -1.1310 | 0.0055 | |
| SRP008496 | ARHGEF3 | 50650 | RNAseq | -1.0189 | 0.0027 | |
| SRP064894 | ARHGEF3 | 50650 | RNAseq | -0.6969 | 0.0023 | |
| SRP133303 | ARHGEF3 | 50650 | RNAseq | -0.7235 | 0.0034 | |
| SRP159526 | ARHGEF3 | 50650 | RNAseq | -1.1604 | 0.0000 | |
| SRP193095 | ARHGEF3 | 50650 | RNAseq | -0.7228 | 0.0000 | |
| SRP219564 | ARHGEF3 | 50650 | RNAseq | -0.5787 | 0.1643 | |
| TCGA | ARHGEF3 | 50650 | RNAseq | -0.1365 | 0.0317 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ARHGEF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF3 | 50650 | 0 | 17 | 13 | |
| GSE20123 | ARHGEF3 | 50650 | 0 | 18 | 12 | |
| GSE43470 | ARHGEF3 | 50650 | 0 | 17 | 26 | |
| GSE46452 | ARHGEF3 | 50650 | 2 | 17 | 40 | |
| GSE47630 | ARHGEF3 | 50650 | 1 | 24 | 15 | |
| GSE54993 | ARHGEF3 | 50650 | 6 | 2 | 62 | |
| GSE54994 | ARHGEF3 | 50650 | 0 | 32 | 21 | |
| GSE60625 | ARHGEF3 | 50650 | 5 | 0 | 6 | |
| GSE74703 | ARHGEF3 | 50650 | 0 | 14 | 22 | |
| GSE74704 | ARHGEF3 | 50650 | 0 | 11 | 9 | |
| TCGA | ARHGEF3 | 50650 | 0 | 79 | 17 |
Total number of gains: 14; Total number of losses: 231; Total Number of normals: 243.
Somatic mutations of ARHGEF3:
Generating mutation plots.
Highly correlated genes for ARHGEF3:
Showing top 20/1322 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF3 | MED4 | 0.771219 | 3 | 0 | 3 |
| ARHGEF3 | TRIM5 | 0.767435 | 4 | 0 | 3 |
| ARHGEF3 | TBC1D20 | 0.736135 | 5 | 0 | 4 |
| ARHGEF3 | TMEM41B | 0.732375 | 3 | 0 | 3 |
| ARHGEF3 | RASSF5 | 0.721929 | 7 | 0 | 7 |
| ARHGEF3 | GTF3C6 | 0.717084 | 4 | 0 | 3 |
| ARHGEF3 | SNX14 | 0.713442 | 3 | 0 | 3 |
| ARHGEF3 | CLDND1 | 0.712981 | 3 | 0 | 3 |
| ARHGEF3 | SAMD9L | 0.711566 | 3 | 0 | 3 |
| ARHGEF3 | RAB5A | 0.709228 | 11 | 0 | 10 |
| ARHGEF3 | NCKAP1 | 0.708151 | 3 | 0 | 3 |
| ARHGEF3 | RNFT1 | 0.703106 | 3 | 0 | 3 |
| ARHGEF3 | TMEM219 | 0.701344 | 4 | 0 | 3 |
| ARHGEF3 | CCNYL1 | 0.700586 | 5 | 0 | 5 |
| ARHGEF3 | RNF144B | 0.699075 | 4 | 0 | 3 |
| ARHGEF3 | PLEKHA7 | 0.698856 | 7 | 0 | 7 |
| ARHGEF3 | BLNK | 0.698465 | 11 | 0 | 11 |
| ARHGEF3 | ARHGEF10L | 0.697173 | 10 | 0 | 10 |
| ARHGEF3 | SCP2 | 0.695652 | 12 | 0 | 11 |
| ARHGEF3 | IMPACT | 0.693948 | 4 | 0 | 3 |
For details and further investigation, click here
