| Full name: protein tyrosine phosphatase 4A1 | Alias Symbol: PTPCAAX1|PRL-1|PRL1 | ||
| Type: protein-coding gene | Cytoband: 6q12 | ||
| Entrez ID: 7803 | HGNC ID: HGNC:9634 | Ensembl Gene: ENSG00000112245 | OMIM ID: 601585 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PTP4A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTP4A1 | 7803 | 200733_s_at | 0.1395 | 0.8774 | |
| GSE20347 | PTP4A1 | 7803 | 200733_s_at | -0.1749 | 0.3756 | |
| GSE23400 | PTP4A1 | 7803 | 200732_s_at | -0.3454 | 0.0000 | |
| GSE26886 | PTP4A1 | 7803 | 200732_s_at | -0.3149 | 0.2594 | |
| GSE29001 | PTP4A1 | 7803 | 200733_s_at | 0.0111 | 0.9727 | |
| GSE38129 | PTP4A1 | 7803 | 200733_s_at | 0.0798 | 0.6845 | |
| GSE45670 | PTP4A1 | 7803 | 200733_s_at | 0.8030 | 0.0002 | |
| GSE53622 | PTP4A1 | 7803 | 55053 | -0.0930 | 0.3118 | |
| GSE53624 | PTP4A1 | 7803 | 55053 | 0.0733 | 0.2384 | |
| GSE63941 | PTP4A1 | 7803 | 200733_s_at | -0.2302 | 0.7340 | |
| GSE77861 | PTP4A1 | 7803 | 200733_s_at | 0.1956 | 0.6093 | |
| GSE97050 | PTP4A1 | 7803 | A_24_P252043 | 0.2634 | 0.3339 | |
| SRP007169 | PTP4A1 | 7803 | RNAseq | 0.0488 | 0.8979 | |
| SRP008496 | PTP4A1 | 7803 | RNAseq | -0.3335 | 0.1938 | |
| SRP064894 | PTP4A1 | 7803 | RNAseq | 0.3015 | 0.2358 | |
| SRP133303 | PTP4A1 | 7803 | RNAseq | 0.6421 | 0.0002 | |
| SRP159526 | PTP4A1 | 7803 | RNAseq | -0.1006 | 0.5734 | |
| SRP193095 | PTP4A1 | 7803 | RNAseq | -0.2251 | 0.1531 | |
| SRP219564 | PTP4A1 | 7803 | RNAseq | 0.9654 | 0.0844 | |
| TCGA | PTP4A1 | 7803 | RNAseq | -0.0502 | 0.3224 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PTP4A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTP4A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTP4A1 | 7803 | 1 | 4 | 25 | |
| GSE20123 | PTP4A1 | 7803 | 1 | 4 | 25 | |
| GSE43470 | PTP4A1 | 7803 | 6 | 0 | 37 | |
| GSE46452 | PTP4A1 | 7803 | 3 | 10 | 46 | |
| GSE47630 | PTP4A1 | 7803 | 8 | 4 | 28 | |
| GSE54993 | PTP4A1 | 7803 | 3 | 2 | 65 | |
| GSE54994 | PTP4A1 | 7803 | 11 | 2 | 40 | |
| GSE60625 | PTP4A1 | 7803 | 0 | 2 | 9 | |
| GSE74703 | PTP4A1 | 7803 | 6 | 0 | 30 | |
| GSE74704 | PTP4A1 | 7803 | 0 | 3 | 17 | |
| TCGA | PTP4A1 | 7803 | 19 | 11 | 66 |
Total number of gains: 58; Total number of losses: 42; Total Number of normals: 388.
Somatic mutations of PTP4A1:
Generating mutation plots.
Highly correlated genes for PTP4A1:
Showing top 20/73 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTP4A1 | RDH11 | 0.689705 | 4 | 0 | 4 |
| PTP4A1 | NSUN2 | 0.686526 | 3 | 0 | 3 |
| PTP4A1 | MED6 | 0.654106 | 4 | 0 | 3 |
| PTP4A1 | FSD1L | 0.631569 | 3 | 0 | 3 |
| PTP4A1 | PABPN1 | 0.615466 | 4 | 0 | 3 |
| PTP4A1 | XDH | 0.611852 | 4 | 0 | 4 |
| PTP4A1 | GTF2A1 | 0.609799 | 3 | 0 | 3 |
| PTP4A1 | SUB1 | 0.606269 | 5 | 0 | 3 |
| PTP4A1 | TCERG1 | 0.605546 | 4 | 0 | 3 |
| PTP4A1 | BMP2K | 0.601813 | 3 | 0 | 3 |
| PTP4A1 | MRPS25 | 0.600146 | 3 | 0 | 3 |
| PTP4A1 | RMDN1 | 0.597921 | 3 | 0 | 3 |
| PTP4A1 | KRT16 | 0.595577 | 3 | 0 | 3 |
| PTP4A1 | MAP3K7 | 0.585779 | 4 | 0 | 3 |
| PTP4A1 | GPX8 | 0.584875 | 4 | 0 | 3 |
| PTP4A1 | MRPL52 | 0.582591 | 5 | 0 | 3 |
| PTP4A1 | ATP2A2 | 0.581602 | 4 | 0 | 3 |
| PTP4A1 | CNN2 | 0.580926 | 4 | 0 | 3 |
| PTP4A1 | GALNT6 | 0.580832 | 4 | 0 | 3 |
| PTP4A1 | UBE2K | 0.577936 | 4 | 0 | 3 |
For details and further investigation, click here
