| Full name: X-ray repair cross complementing 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q32.33 | ||
| Entrez ID: 7517 | HGNC ID: HGNC:12830 | Ensembl Gene: ENSG00000126215 | OMIM ID: 600675 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of XRCC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XRCC3 | 7517 | 216299_s_at | 0.9070 | 0.0330 | |
| GSE20347 | XRCC3 | 7517 | 216299_s_at | 0.5689 | 0.0000 | |
| GSE23400 | XRCC3 | 7517 | 216299_s_at | 0.2191 | 0.0000 | |
| GSE26886 | XRCC3 | 7517 | 216299_s_at | 0.4445 | 0.0035 | |
| GSE29001 | XRCC3 | 7517 | 216299_s_at | 0.3113 | 0.1540 | |
| GSE38129 | XRCC3 | 7517 | 216299_s_at | 0.5257 | 0.0000 | |
| GSE45670 | XRCC3 | 7517 | 216299_s_at | 0.4179 | 0.0000 | |
| GSE53622 | XRCC3 | 7517 | 18177 | 0.7315 | 0.0000 | |
| GSE53624 | XRCC3 | 7517 | 18177 | 1.2270 | 0.0000 | |
| GSE63941 | XRCC3 | 7517 | 216299_s_at | 1.0323 | 0.0100 | |
| GSE77861 | XRCC3 | 7517 | 216299_s_at | 0.0153 | 0.9330 | |
| GSE97050 | XRCC3 | 7517 | A_33_P3363515 | 0.3962 | 0.1479 | |
| SRP007169 | XRCC3 | 7517 | RNAseq | 1.9029 | 0.0000 | |
| SRP008496 | XRCC3 | 7517 | RNAseq | 1.5435 | 0.0000 | |
| SRP064894 | XRCC3 | 7517 | RNAseq | 0.6273 | 0.0041 | |
| SRP133303 | XRCC3 | 7517 | RNAseq | 0.3004 | 0.0122 | |
| SRP159526 | XRCC3 | 7517 | RNAseq | 1.3100 | 0.0177 | |
| SRP193095 | XRCC3 | 7517 | RNAseq | 0.7483 | 0.0000 | |
| SRP219564 | XRCC3 | 7517 | RNAseq | 0.4388 | 0.1369 | |
| TCGA | XRCC3 | 7517 | RNAseq | 0.2906 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by XRCC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XRCC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XRCC3 | 7517 | 12 | 3 | 15 | |
| GSE20123 | XRCC3 | 7517 | 11 | 2 | 17 | |
| GSE43470 | XRCC3 | 7517 | 6 | 4 | 33 | |
| GSE46452 | XRCC3 | 7517 | 18 | 4 | 37 | |
| GSE47630 | XRCC3 | 7517 | 10 | 8 | 22 | |
| GSE54993 | XRCC3 | 7517 | 3 | 8 | 59 | |
| GSE54994 | XRCC3 | 7517 | 21 | 4 | 28 | |
| GSE60625 | XRCC3 | 7517 | 0 | 2 | 9 | |
| GSE74703 | XRCC3 | 7517 | 5 | 3 | 28 | |
| GSE74704 | XRCC3 | 7517 | 5 | 2 | 13 | |
| TCGA | XRCC3 | 7517 | 31 | 20 | 45 |
Total number of gains: 122; Total number of losses: 60; Total Number of normals: 306.
Somatic mutations of XRCC3:
Generating mutation plots.
Highly correlated genes for XRCC3:
Showing top 20/1043 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XRCC3 | MYBL2 | 0.751522 | 9 | 0 | 9 |
| XRCC3 | BOLA3 | 0.72432 | 5 | 0 | 5 |
| XRCC3 | TROAP | 0.699629 | 10 | 0 | 10 |
| XRCC3 | CENPBD1 | 0.687449 | 3 | 0 | 3 |
| XRCC3 | ATAD2 | 0.684702 | 8 | 0 | 8 |
| XRCC3 | ZFP41 | 0.684429 | 5 | 0 | 5 |
| XRCC3 | ROMO1 | 0.684221 | 3 | 0 | 3 |
| XRCC3 | HJURP | 0.679756 | 8 | 0 | 7 |
| XRCC3 | PKMYT1 | 0.679532 | 8 | 0 | 8 |
| XRCC3 | CDKN3 | 0.679334 | 9 | 0 | 8 |
| XRCC3 | CMSS1 | 0.675377 | 6 | 0 | 6 |
| XRCC3 | UBE2C | 0.675009 | 9 | 0 | 8 |
| XRCC3 | ZGRF1 | 0.672501 | 5 | 0 | 5 |
| XRCC3 | CENPI | 0.672339 | 8 | 0 | 7 |
| XRCC3 | VRK1 | 0.667328 | 9 | 0 | 8 |
| XRCC3 | AUNIP | 0.664947 | 9 | 0 | 9 |
| XRCC3 | DEPDC1B | 0.663442 | 5 | 0 | 5 |
| XRCC3 | ANLN | 0.66209 | 4 | 0 | 4 |
| XRCC3 | STRIP2 | 0.660235 | 5 | 0 | 5 |
| XRCC3 | UBE2T | 0.660195 | 6 | 0 | 6 |
For details and further investigation, click here
