| Full name: structural maintenance of chromosomes 1B | Alias Symbol: bK268H5 | ||
| Type: protein-coding gene | Cytoband: 22q13.31 | ||
| Entrez ID: 27127 | HGNC ID: HGNC:11112 | Ensembl Gene: ENSG00000077935 | OMIM ID: 608685 |
| Drug and gene relationship at DGIdb | |||
SMC1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of SMC1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMC1B | 27127 | 1553249_at | 0.1846 | 0.4463 | |
| GSE26886 | SMC1B | 27127 | 1553249_at | 0.0441 | 0.7247 | |
| GSE45670 | SMC1B | 27127 | 1553249_at | 0.0770 | 0.3994 | |
| GSE53622 | SMC1B | 27127 | 33729 | 0.2318 | 0.1784 | |
| GSE53624 | SMC1B | 27127 | 33729 | 0.4912 | 0.0002 | |
| GSE63941 | SMC1B | 27127 | 1553249_at | 0.0612 | 0.7450 | |
| GSE77861 | SMC1B | 27127 | 1553249_at | 0.0023 | 0.9874 | |
| GSE97050 | SMC1B | 27127 | A_23_P29330 | -0.0914 | 0.7172 | |
| SRP133303 | SMC1B | 27127 | RNAseq | 1.5307 | 0.0003 | |
| TCGA | SMC1B | 27127 | RNAseq | 2.1879 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SMC1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMC1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMC1B | 27127 | 5 | 6 | 19 | |
| GSE20123 | SMC1B | 27127 | 4 | 5 | 21 | |
| GSE43470 | SMC1B | 27127 | 2 | 6 | 35 | |
| GSE46452 | SMC1B | 27127 | 31 | 2 | 26 | |
| GSE47630 | SMC1B | 27127 | 9 | 4 | 27 | |
| GSE54993 | SMC1B | 27127 | 3 | 6 | 61 | |
| GSE54994 | SMC1B | 27127 | 11 | 7 | 35 | |
| GSE60625 | SMC1B | 27127 | 5 | 0 | 6 | |
| GSE74703 | SMC1B | 27127 | 2 | 4 | 30 | |
| GSE74704 | SMC1B | 27127 | 2 | 3 | 15 | |
| TCGA | SMC1B | 27127 | 27 | 15 | 54 |
Total number of gains: 101; Total number of losses: 58; Total Number of normals: 329.
Somatic mutations of SMC1B:
Generating mutation plots.
Highly correlated genes for SMC1B:
Showing top 20/30 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMC1B | MEP1A | 0.736462 | 3 | 0 | 3 |
| SMC1B | GOLGA6L6 | 0.719096 | 3 | 0 | 3 |
| SMC1B | ATP2B2 | 0.69961 | 3 | 0 | 3 |
| SMC1B | CDH4 | 0.693873 | 3 | 0 | 3 |
| SMC1B | DNLZ | 0.691719 | 3 | 0 | 3 |
| SMC1B | SPACA3 | 0.691657 | 3 | 0 | 3 |
| SMC1B | FBXO15 | 0.68953 | 3 | 0 | 3 |
| SMC1B | CEMP1 | 0.683114 | 3 | 0 | 3 |
| SMC1B | PSTPIP1 | 0.676445 | 3 | 0 | 3 |
| SMC1B | SLC22A31 | 0.65394 | 3 | 0 | 3 |
| SMC1B | HOTAIR | 0.650952 | 4 | 0 | 3 |
| SMC1B | ZNF221 | 0.642166 | 3 | 0 | 3 |
| SMC1B | TUBGCP6 | 0.63681 | 3 | 0 | 3 |
| SMC1B | ZNF133 | 0.626523 | 3 | 0 | 3 |
| SMC1B | PFN4 | 0.626367 | 3 | 0 | 3 |
| SMC1B | NFYA | 0.625826 | 3 | 0 | 3 |
| SMC1B | BTBD8 | 0.619401 | 3 | 0 | 3 |
| SMC1B | SLC2A11 | 0.610507 | 3 | 0 | 3 |
| SMC1B | BCL6B | 0.600164 | 3 | 0 | 3 |
| SMC1B | PICK1 | 0.593948 | 3 | 0 | 3 |
For details and further investigation, click here
