| Full name: MER proto-oncogene, tyrosine kinase | Alias Symbol: mer|RP38|c-Eyk|Tyro12 | ||
| Type: protein-coding gene | Cytoband: 2q13 | ||
| Entrez ID: 10461 | HGNC ID: HGNC:7027 | Ensembl Gene: ENSG00000153208 | OMIM ID: 604705 |
| Drug and gene relationship at DGIdb | |||
Expression of MERTK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MERTK | 10461 | 206028_s_at | -0.4584 | 0.5344 | |
| GSE20347 | MERTK | 10461 | 206028_s_at | 0.4310 | 0.0718 | |
| GSE23400 | MERTK | 10461 | 206028_s_at | 0.2447 | 0.0010 | |
| GSE26886 | MERTK | 10461 | 206028_s_at | 0.1714 | 0.7684 | |
| GSE29001 | MERTK | 10461 | 206028_s_at | 0.3533 | 0.3864 | |
| GSE38129 | MERTK | 10461 | 206028_s_at | 0.5949 | 0.0072 | |
| GSE45670 | MERTK | 10461 | 206028_s_at | -0.3860 | 0.2775 | |
| GSE53622 | MERTK | 10461 | 102829 | 0.2248 | 0.0381 | |
| GSE53624 | MERTK | 10461 | 7669 | 0.3187 | 0.0096 | |
| GSE63941 | MERTK | 10461 | 206028_s_at | 0.8459 | 0.2844 | |
| GSE77861 | MERTK | 10461 | 211913_s_at | 0.2077 | 0.1820 | |
| GSE97050 | MERTK | 10461 | A_33_P3402086 | 0.1720 | 0.6617 | |
| SRP007169 | MERTK | 10461 | RNAseq | 1.0686 | 0.0112 | |
| SRP008496 | MERTK | 10461 | RNAseq | 0.7895 | 0.0188 | |
| SRP064894 | MERTK | 10461 | RNAseq | 0.0989 | 0.7763 | |
| SRP133303 | MERTK | 10461 | RNAseq | 0.6855 | 0.0016 | |
| SRP159526 | MERTK | 10461 | RNAseq | 0.2892 | 0.5748 | |
| SRP193095 | MERTK | 10461 | RNAseq | 0.1512 | 0.4488 | |
| SRP219564 | MERTK | 10461 | RNAseq | 0.3006 | 0.4096 | |
| TCGA | MERTK | 10461 | RNAseq | -0.1771 | 0.2183 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MERTK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MERTK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MERTK | 10461 | 6 | 2 | 22 | |
| GSE20123 | MERTK | 10461 | 6 | 2 | 22 | |
| GSE43470 | MERTK | 10461 | 3 | 1 | 39 | |
| GSE46452 | MERTK | 10461 | 1 | 4 | 54 | |
| GSE47630 | MERTK | 10461 | 7 | 0 | 33 | |
| GSE54993 | MERTK | 10461 | 0 | 6 | 64 | |
| GSE54994 | MERTK | 10461 | 10 | 0 | 43 | |
| GSE60625 | MERTK | 10461 | 0 | 3 | 8 | |
| GSE74703 | MERTK | 10461 | 3 | 1 | 32 | |
| GSE74704 | MERTK | 10461 | 3 | 2 | 15 | |
| TCGA | MERTK | 10461 | 31 | 5 | 60 |
Total number of gains: 70; Total number of losses: 26; Total Number of normals: 392.
Somatic mutations of MERTK:
Generating mutation plots.
Highly correlated genes for MERTK:
Showing top 20/31 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MERTK | ABHD11 | 0.661367 | 3 | 0 | 3 |
| MERTK | TRABD | 0.594315 | 3 | 0 | 3 |
| MERTK | PPP1CA | 0.584696 | 3 | 0 | 3 |
| MERTK | SND1 | 0.584046 | 3 | 0 | 3 |
| MERTK | NUDT16 | 0.580591 | 4 | 0 | 3 |
| MERTK | HVCN1 | 0.576018 | 3 | 0 | 3 |
| MERTK | COX4I1 | 0.570188 | 3 | 0 | 3 |
| MERTK | RPL19 | 0.545338 | 5 | 0 | 3 |
| MERTK | LINC01206 | 0.543533 | 4 | 0 | 3 |
| MERTK | VSIG4 | 0.536537 | 8 | 0 | 4 |
| MERTK | SPIDR | 0.536062 | 6 | 0 | 4 |
| MERTK | CNNM3 | 0.534415 | 5 | 0 | 4 |
| MERTK | FCGR1B | 0.531255 | 5 | 0 | 3 |
| MERTK | GCLC | 0.531012 | 4 | 0 | 3 |
| MERTK | SEC61A2 | 0.530107 | 6 | 0 | 4 |
| MERTK | VOPP1 | 0.526992 | 5 | 0 | 3 |
| MERTK | IGFLR1 | 0.526332 | 4 | 0 | 3 |
| MERTK | HHAT | 0.524988 | 5 | 0 | 3 |
| MERTK | RNF130 | 0.524138 | 11 | 0 | 6 |
| MERTK | C2 | 0.522533 | 6 | 0 | 3 |
For details and further investigation, click here
