| Full name: kelch like family member 18 | Alias Symbol: KIAA0795|FLJ13703 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 23276 | HGNC ID: HGNC:29120 | Ensembl Gene: ENSG00000114648 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of KLHL18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHL18 | 23276 | 212882_at | 0.1341 | 0.6656 | |
| GSE20347 | KLHL18 | 23276 | 212882_at | -0.3129 | 0.0339 | |
| GSE23400 | KLHL18 | 23276 | 212882_at | -0.1346 | 0.0000 | |
| GSE26886 | KLHL18 | 23276 | 212882_at | -0.9839 | 0.0000 | |
| GSE29001 | KLHL18 | 23276 | 212882_at | -0.4791 | 0.0035 | |
| GSE38129 | KLHL18 | 23276 | 212882_at | -0.2972 | 0.0108 | |
| GSE45670 | KLHL18 | 23276 | 212882_at | 0.0278 | 0.8775 | |
| GSE53622 | KLHL18 | 23276 | 11114 | -0.4663 | 0.0000 | |
| GSE53624 | KLHL18 | 23276 | 11114 | -0.5787 | 0.0000 | |
| GSE63941 | KLHL18 | 23276 | 212882_at | -1.3283 | 0.0044 | |
| GSE77861 | KLHL18 | 23276 | 1557165_s_at | -0.4139 | 0.0298 | |
| GSE97050 | KLHL18 | 23276 | A_24_P15043 | 0.0876 | 0.7319 | |
| SRP007169 | KLHL18 | 23276 | RNAseq | -0.9172 | 0.0284 | |
| SRP008496 | KLHL18 | 23276 | RNAseq | -0.8212 | 0.0036 | |
| SRP064894 | KLHL18 | 23276 | RNAseq | -0.6090 | 0.0000 | |
| SRP133303 | KLHL18 | 23276 | RNAseq | -0.3287 | 0.0172 | |
| SRP159526 | KLHL18 | 23276 | RNAseq | -0.7815 | 0.0132 | |
| SRP193095 | KLHL18 | 23276 | RNAseq | -0.4772 | 0.0000 | |
| SRP219564 | KLHL18 | 23276 | RNAseq | -0.7668 | 0.0015 | |
| TCGA | KLHL18 | 23276 | RNAseq | -0.1714 | 0.0033 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KLHL18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHL18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHL18 | 23276 | 0 | 18 | 12 | |
| GSE20123 | KLHL18 | 23276 | 0 | 19 | 11 | |
| GSE43470 | KLHL18 | 23276 | 0 | 19 | 24 | |
| GSE46452 | KLHL18 | 23276 | 2 | 17 | 40 | |
| GSE47630 | KLHL18 | 23276 | 2 | 23 | 15 | |
| GSE54993 | KLHL18 | 23276 | 7 | 2 | 61 | |
| GSE54994 | KLHL18 | 23276 | 0 | 36 | 17 | |
| GSE60625 | KLHL18 | 23276 | 5 | 0 | 6 | |
| GSE74703 | KLHL18 | 23276 | 0 | 15 | 21 | |
| GSE74704 | KLHL18 | 23276 | 0 | 12 | 8 | |
| TCGA | KLHL18 | 23276 | 1 | 75 | 20 |
Total number of gains: 17; Total number of losses: 236; Total Number of normals: 235.
Somatic mutations of KLHL18:
Generating mutation plots.
Highly correlated genes for KLHL18:
Showing top 20/948 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHL18 | GMPPB | 0.818609 | 3 | 0 | 3 |
| KLHL18 | PPT2 | 0.751021 | 3 | 0 | 3 |
| KLHL18 | ATP6V1G2 | 0.748742 | 3 | 0 | 3 |
| KLHL18 | METTL14 | 0.74682 | 3 | 0 | 3 |
| KLHL18 | GPR108 | 0.741542 | 3 | 0 | 3 |
| KLHL18 | ZNF844 | 0.728618 | 4 | 0 | 4 |
| KLHL18 | NAA35 | 0.726985 | 3 | 0 | 3 |
| KLHL18 | TMEM167A | 0.723639 | 3 | 0 | 3 |
| KLHL18 | ZNF407 | 0.722916 | 3 | 0 | 3 |
| KLHL18 | ZNF92 | 0.719666 | 3 | 0 | 3 |
| KLHL18 | TP53RK | 0.714812 | 3 | 0 | 3 |
| KLHL18 | COPS3 | 0.71456 | 3 | 0 | 3 |
| KLHL18 | ELOVL1 | 0.707771 | 3 | 0 | 3 |
| KLHL18 | VPS26B | 0.70736 | 3 | 0 | 3 |
| KLHL18 | LYSMD3 | 0.707314 | 5 | 0 | 4 |
| KLHL18 | TAX1BP3 | 0.702618 | 3 | 0 | 3 |
| KLHL18 | PICALM | 0.702258 | 3 | 0 | 3 |
| KLHL18 | PITHD1 | 0.702158 | 6 | 0 | 6 |
| KLHL18 | RRM2B | 0.701395 | 3 | 0 | 3 |
| KLHL18 | COMMD1 | 0.69802 | 3 | 0 | 3 |
For details and further investigation, click here
