METTL5

 

Full name: methyltransferase like 5 Alias Symbol: HSPC133
Type: protein-coding gene Cytoband: 2q31.1
Entrez ID: 29081 HGNC ID: HGNC:25006 Ensembl Gene: ENSG00000138382 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of METTL5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 METTL5 29081 221570_s_at 0.4094 0.5117
GSE20347 METTL5 29081 221570_s_at 0.7694 0.0000
GSE23400 METTL5 29081 221570_s_at 0.7819 0.0000
GSE26886 METTL5 29081 221570_s_at 1.2094 0.0000
GSE29001 METTL5 29081 221570_s_at 0.8961 0.0243
GSE38129 METTL5 29081 221570_s_at 0.5864 0.0000
GSE45670 METTL5 29081 221570_s_at 0.2148 0.2014
GSE53622 METTL5 29081 27044 0.4706 0.0000
GSE53624 METTL5 29081 27044 0.7936 0.0000
GSE63941 METTL5 29081 221570_s_at 0.9166 0.0121
GSE77861 METTL5 29081 221570_s_at 0.6718 0.0102
GSE97050 METTL5 29081 A_33_P3272461 -0.0222 0.9474
SRP007169 METTL5 29081 RNAseq 0.3856 0.3778
SRP008496 METTL5 29081 RNAseq 0.6376 0.0090
SRP064894 METTL5 29081 RNAseq 0.3809 0.0651
SRP133303 METTL5 29081 RNAseq 0.5585 0.0002
SRP159526 METTL5 29081 RNAseq 0.1080 0.6646
SRP193095 METTL5 29081 RNAseq 0.1428 0.3543
SRP219564 METTL5 29081 RNAseq -0.0178 0.9616
TCGA METTL5 29081 RNAseq 0.1109 0.0470

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by METTL5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of METTL5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 METTL5 29081 8 0 22
GSE20123 METTL5 29081 8 0 22
GSE43470 METTL5 29081 4 1 38
GSE46452 METTL5 29081 1 4 54
GSE47630 METTL5 29081 5 3 32
GSE54993 METTL5 29081 0 5 65
GSE54994 METTL5 29081 11 3 39
GSE60625 METTL5 29081 0 3 8
GSE74703 METTL5 29081 3 1 32
GSE74704 METTL5 29081 4 0 16
TCGA METTL5 29081 24 10 62

Total number of gains: 68; Total number of losses: 30; Total Number of normals: 390.  

 

Somatic mutations of METTL5:

 

Generating mutation plots.

 

Highly correlated genes for METTL5:

 

Showing top 20/1513 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
METTL5ANAPC40.843369303
METTL5SMCR80.831193303
METTL5SSB0.80583713012
METTL5TMTC10.78767303
METTL5PPP1R16A0.780584303
METTL5METTL140.764022303
METTL5RBM40.755584303
METTL5NDUFS40.752527303
METTL5ASNSD10.7443721009
METTL5MRFAP10.742077303
METTL5MAGOH0.737386303
METTL5ZNF7660.737371303
METTL5DUS3L0.733183404
METTL5STK30.73006111011
METTL5UBXN2A0.724056303
METTL5PSMD140.72060712012
METTL5SFSWAP0.719997303
METTL5KLHL50.715477404
METTL5NRARP0.7142303
METTL5DHX360.712995808

For details and further investigation, click here