| Full name: DEP domain containing 5 | Alias Symbol: KIAA0645|DEP.5 | ||
| Type: protein-coding gene | Cytoband: 22q12.2-q12.3 | ||
| Entrez ID: 9681 | HGNC ID: HGNC:18423 | Ensembl Gene: ENSG00000100150 | OMIM ID: 614191 |
| Drug and gene relationship at DGIdb | |||
DEPDC5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of DEPDC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEPDC5 | 9681 | 205223_at | 0.1091 | 0.6911 | |
| GSE20347 | DEPDC5 | 9681 | 205223_at | 0.0157 | 0.8960 | |
| GSE23400 | DEPDC5 | 9681 | 205223_at | -0.0303 | 0.4765 | |
| GSE26886 | DEPDC5 | 9681 | 205223_at | -0.2535 | 0.2112 | |
| GSE29001 | DEPDC5 | 9681 | 205223_at | 0.0052 | 0.9841 | |
| GSE38129 | DEPDC5 | 9681 | 205223_at | -0.0568 | 0.4976 | |
| GSE45670 | DEPDC5 | 9681 | 205223_at | 0.1687 | 0.0875 | |
| GSE53622 | DEPDC5 | 9681 | 158021 | 0.1203 | 0.0274 | |
| GSE53624 | DEPDC5 | 9681 | 70906 | -0.0124 | 0.8746 | |
| GSE63941 | DEPDC5 | 9681 | 205223_at | 0.2964 | 0.1926 | |
| GSE77861 | DEPDC5 | 9681 | 205223_at | 0.1982 | 0.2381 | |
| GSE97050 | DEPDC5 | 9681 | A_33_P3212221 | 0.2643 | 0.2773 | |
| SRP007169 | DEPDC5 | 9681 | RNAseq | 0.4035 | 0.3243 | |
| SRP008496 | DEPDC5 | 9681 | RNAseq | 0.3686 | 0.4023 | |
| SRP064894 | DEPDC5 | 9681 | RNAseq | 0.2215 | 0.2809 | |
| SRP133303 | DEPDC5 | 9681 | RNAseq | -0.0858 | 0.3601 | |
| SRP159526 | DEPDC5 | 9681 | RNAseq | 0.2698 | 0.1876 | |
| SRP193095 | DEPDC5 | 9681 | RNAseq | 0.0295 | 0.7887 | |
| SRP219564 | DEPDC5 | 9681 | RNAseq | 0.3544 | 0.2612 | |
| TCGA | DEPDC5 | 9681 | RNAseq | -0.0361 | 0.5065 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEPDC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEPDC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEPDC5 | 9681 | 4 | 4 | 22 | |
| GSE20123 | DEPDC5 | 9681 | 4 | 3 | 23 | |
| GSE43470 | DEPDC5 | 9681 | 4 | 5 | 34 | |
| GSE46452 | DEPDC5 | 9681 | 31 | 1 | 27 | |
| GSE47630 | DEPDC5 | 9681 | 8 | 5 | 27 | |
| GSE54993 | DEPDC5 | 9681 | 3 | 6 | 61 | |
| GSE54994 | DEPDC5 | 9681 | 10 | 9 | 34 | |
| GSE60625 | DEPDC5 | 9681 | 5 | 0 | 6 | |
| GSE74703 | DEPDC5 | 9681 | 4 | 5 | 27 | |
| GSE74704 | DEPDC5 | 9681 | 1 | 1 | 18 | |
| TCGA | DEPDC5 | 9681 | 27 | 16 | 53 |
Total number of gains: 101; Total number of losses: 55; Total Number of normals: 332.
Somatic mutations of DEPDC5:
Generating mutation plots.
Highly correlated genes for DEPDC5:
Showing top 20/297 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEPDC5 | METTL17 | 0.730144 | 3 | 0 | 3 |
| DEPDC5 | FAM193B | 0.723622 | 3 | 0 | 3 |
| DEPDC5 | CSNK1D | 0.723563 | 3 | 0 | 3 |
| DEPDC5 | KIAA1257 | 0.718346 | 3 | 0 | 3 |
| DEPDC5 | MED15 | 0.711874 | 3 | 0 | 3 |
| DEPDC5 | STAT6 | 0.702085 | 3 | 0 | 3 |
| DEPDC5 | NDUFS6 | 0.697653 | 3 | 0 | 3 |
| DEPDC5 | MMP15 | 0.692751 | 3 | 0 | 3 |
| DEPDC5 | CLDN18 | 0.68977 | 3 | 0 | 3 |
| DEPDC5 | USP11 | 0.688309 | 3 | 0 | 3 |
| DEPDC5 | CDK2AP2 | 0.6838 | 3 | 0 | 3 |
| DEPDC5 | ARHGDIA | 0.683612 | 3 | 0 | 3 |
| DEPDC5 | SHMT2 | 0.682334 | 4 | 0 | 3 |
| DEPDC5 | ILF2 | 0.681747 | 3 | 0 | 3 |
| DEPDC5 | G6PC3 | 0.679832 | 3 | 0 | 3 |
| DEPDC5 | RAB1B | 0.677718 | 3 | 0 | 3 |
| DEPDC5 | LY6E | 0.677175 | 3 | 0 | 3 |
| DEPDC5 | C19orf47 | 0.668546 | 3 | 0 | 3 |
| DEPDC5 | NONO | 0.66844 | 3 | 0 | 3 |
| DEPDC5 | ZAP70 | 0.6684 | 3 | 0 | 3 |
For details and further investigation, click here
