| Full name: mitofusin 2 | Alias Symbol: CPRP1|KIAA0214|MARF|CMT2A2 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 9927 | HGNC ID: HGNC:16877 | Ensembl Gene: ENSG00000116688 | OMIM ID: 608507 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MFN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MFN2 | 9927 | 201155_s_at | 0.2991 | 0.5403 | |
| GSE20347 | MFN2 | 9927 | 201155_s_at | 0.1688 | 0.2240 | |
| GSE23400 | MFN2 | 9927 | 201155_s_at | 0.0706 | 0.3255 | |
| GSE26886 | MFN2 | 9927 | 201155_s_at | 0.0201 | 0.9500 | |
| GSE29001 | MFN2 | 9927 | 201155_s_at | 0.3768 | 0.1981 | |
| GSE38129 | MFN2 | 9927 | 201155_s_at | 0.0184 | 0.9065 | |
| GSE45670 | MFN2 | 9927 | 201155_s_at | 0.2117 | 0.1529 | |
| GSE53622 | MFN2 | 9927 | 55097 | -0.2650 | 0.0007 | |
| GSE53624 | MFN2 | 9927 | 55097 | 0.1361 | 0.0069 | |
| GSE63941 | MFN2 | 9927 | 201155_s_at | 0.1186 | 0.7362 | |
| GSE77861 | MFN2 | 9927 | 201155_s_at | 0.0968 | 0.6123 | |
| GSE97050 | MFN2 | 9927 | A_23_P126135 | -0.3794 | 0.3507 | |
| SRP007169 | MFN2 | 9927 | RNAseq | -0.1816 | 0.6977 | |
| SRP008496 | MFN2 | 9927 | RNAseq | -0.4003 | 0.1159 | |
| SRP064894 | MFN2 | 9927 | RNAseq | 0.0634 | 0.6235 | |
| SRP133303 | MFN2 | 9927 | RNAseq | 0.3660 | 0.0616 | |
| SRP159526 | MFN2 | 9927 | RNAseq | -0.2565 | 0.2344 | |
| SRP193095 | MFN2 | 9927 | RNAseq | 0.3073 | 0.0103 | |
| SRP219564 | MFN2 | 9927 | RNAseq | -0.4636 | 0.2443 | |
| TCGA | MFN2 | 9927 | RNAseq | -0.0685 | 0.1206 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MFN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MFN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MFN2 | 9927 | 0 | 5 | 25 | |
| GSE20123 | MFN2 | 9927 | 0 | 4 | 26 | |
| GSE43470 | MFN2 | 9927 | 4 | 6 | 33 | |
| GSE46452 | MFN2 | 9927 | 7 | 1 | 51 | |
| GSE47630 | MFN2 | 9927 | 8 | 4 | 28 | |
| GSE54993 | MFN2 | 9927 | 3 | 1 | 66 | |
| GSE54994 | MFN2 | 9927 | 11 | 4 | 38 | |
| GSE60625 | MFN2 | 9927 | 0 | 0 | 11 | |
| GSE74703 | MFN2 | 9927 | 3 | 4 | 29 | |
| GSE74704 | MFN2 | 9927 | 0 | 0 | 20 | |
| TCGA | MFN2 | 9927 | 11 | 22 | 63 |
Total number of gains: 47; Total number of losses: 51; Total Number of normals: 390.
Somatic mutations of MFN2:
Generating mutation plots.
Highly correlated genes for MFN2:
Showing top 20/231 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MFN2 | C5orf51 | 0.764761 | 3 | 0 | 3 |
| MFN2 | KRR1 | 0.728686 | 3 | 0 | 3 |
| MFN2 | PAIP1 | 0.726113 | 3 | 0 | 3 |
| MFN2 | ZSCAN21 | 0.724582 | 3 | 0 | 3 |
| MFN2 | FRA10AC1 | 0.723503 | 3 | 0 | 3 |
| MFN2 | P2RX7 | 0.721421 | 3 | 0 | 3 |
| MFN2 | GOLPH3 | 0.719408 | 3 | 0 | 3 |
| MFN2 | C12orf43 | 0.717701 | 3 | 0 | 3 |
| MFN2 | UBP1 | 0.711056 | 3 | 0 | 3 |
| MFN2 | MZT2B | 0.692896 | 3 | 0 | 3 |
| MFN2 | MOB3C | 0.691279 | 4 | 0 | 4 |
| MFN2 | NOC3L | 0.688395 | 3 | 0 | 3 |
| MFN2 | DHPS | 0.686557 | 3 | 0 | 3 |
| MFN2 | GET4 | 0.67815 | 3 | 0 | 3 |
| MFN2 | CHKA | 0.673448 | 3 | 0 | 3 |
| MFN2 | ZNF74 | 0.670857 | 3 | 0 | 3 |
| MFN2 | MLLT1 | 0.669019 | 3 | 0 | 3 |
| MFN2 | NEO1 | 0.667193 | 3 | 0 | 3 |
| MFN2 | NAA30 | 0.660314 | 3 | 0 | 3 |
| MFN2 | ADRB1 | 0.658927 | 3 | 0 | 3 |
For details and further investigation, click here
