| Full name: mutL homolog 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 27030 | HGNC ID: HGNC:7128 | Ensembl Gene: ENSG00000119684 | OMIM ID: 604395 |
| Drug and gene relationship at DGIdb | |||
Expression of MLH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MLH3 | 27030 | 204838_s_at | -0.2314 | 0.7000 | |
| GSE20347 | MLH3 | 27030 | 204838_s_at | 0.3414 | 0.0524 | |
| GSE23400 | MLH3 | 27030 | 204838_s_at | 0.1593 | 0.0031 | |
| GSE26886 | MLH3 | 27030 | 204838_s_at | 1.3399 | 0.0035 | |
| GSE29001 | MLH3 | 27030 | 204838_s_at | 0.1339 | 0.6864 | |
| GSE38129 | MLH3 | 27030 | 204838_s_at | 0.1883 | 0.2159 | |
| GSE45670 | MLH3 | 27030 | 204838_s_at | -0.2173 | 0.2069 | |
| GSE53622 | MLH3 | 27030 | 82119 | 0.3752 | 0.0003 | |
| GSE53624 | MLH3 | 27030 | 82119 | 0.4705 | 0.0000 | |
| GSE63941 | MLH3 | 27030 | 204838_s_at | -0.6612 | 0.5302 | |
| GSE77861 | MLH3 | 27030 | 204838_s_at | 0.1085 | 0.7136 | |
| GSE97050 | MLH3 | 27030 | A_33_P3636080 | 0.0426 | 0.8970 | |
| SRP007169 | MLH3 | 27030 | RNAseq | 1.2216 | 0.0079 | |
| SRP008496 | MLH3 | 27030 | RNAseq | 1.2742 | 0.0001 | |
| SRP064894 | MLH3 | 27030 | RNAseq | 0.1496 | 0.2744 | |
| SRP133303 | MLH3 | 27030 | RNAseq | -0.0890 | 0.6148 | |
| SRP159526 | MLH3 | 27030 | RNAseq | 0.0456 | 0.8595 | |
| SRP193095 | MLH3 | 27030 | RNAseq | 0.0415 | 0.7049 | |
| SRP219564 | MLH3 | 27030 | RNAseq | -0.2033 | 0.5226 | |
| TCGA | MLH3 | 27030 | RNAseq | 0.0048 | 0.9453 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by MLH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MLH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MLH3 | 27030 | 8 | 3 | 19 | |
| GSE20123 | MLH3 | 27030 | 8 | 3 | 19 | |
| GSE43470 | MLH3 | 27030 | 8 | 3 | 32 | |
| GSE46452 | MLH3 | 27030 | 16 | 3 | 40 | |
| GSE47630 | MLH3 | 27030 | 11 | 8 | 21 | |
| GSE54993 | MLH3 | 27030 | 3 | 8 | 59 | |
| GSE54994 | MLH3 | 27030 | 19 | 4 | 30 | |
| GSE60625 | MLH3 | 27030 | 0 | 2 | 9 | |
| GSE74703 | MLH3 | 27030 | 7 | 3 | 26 | |
| GSE74704 | MLH3 | 27030 | 3 | 3 | 14 | |
| TCGA | MLH3 | 27030 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.
Somatic mutations of MLH3:
Generating mutation plots.
Highly correlated genes for MLH3:
Showing top 20/272 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MLH3 | PDK3 | 0.772091 | 3 | 0 | 3 |
| MLH3 | ZSCAN21 | 0.768688 | 3 | 0 | 3 |
| MLH3 | NPHP3 | 0.758404 | 3 | 0 | 3 |
| MLH3 | SPAG7 | 0.752045 | 3 | 0 | 3 |
| MLH3 | RBM26 | 0.745475 | 3 | 0 | 3 |
| MLH3 | ZNF121 | 0.744099 | 3 | 0 | 3 |
| MLH3 | CWC22 | 0.732231 | 3 | 0 | 3 |
| MLH3 | MRFAP1L1 | 0.729866 | 3 | 0 | 3 |
| MLH3 | FAM160A2 | 0.714205 | 3 | 0 | 3 |
| MLH3 | RTN3 | 0.70405 | 3 | 0 | 3 |
| MLH3 | DDX20 | 0.703992 | 3 | 0 | 3 |
| MLH3 | PDE7A | 0.701306 | 3 | 0 | 3 |
| MLH3 | C12orf65 | 0.696078 | 3 | 0 | 3 |
| MLH3 | CASC4 | 0.690252 | 3 | 0 | 3 |
| MLH3 | FUBP1 | 0.688422 | 4 | 0 | 3 |
| MLH3 | KANSL2 | 0.687722 | 3 | 0 | 3 |
| MLH3 | POC5 | 0.683679 | 3 | 0 | 3 |
| MLH3 | WBP4 | 0.679085 | 3 | 0 | 3 |
| MLH3 | GTPBP6 | 0.675166 | 3 | 0 | 3 |
| MLH3 | NSMCE2 | 0.674591 | 5 | 0 | 4 |
For details and further investigation, click here
