TNFRSF1A

 

Full name: TNF receptor superfamily member 1A Alias Symbol: TNF-R|TNFAR|TNFR60|TNF-R-I|CD120a|TNF-R55
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 7132 HGNC ID: HGNC:11916 Ensembl Gene: ENSG00000067182 OMIM ID: 191190
Drug and gene relationship at DGIdb

 

TNFRSF1A involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04150mTOR signaling pathway
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa04668TNF signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa05010Alzheimer's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05166HTLV-I infection
hsa05168Herpes simplex infection

 

Expression of TNFRSF1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TNFRSF1A 7132 207643_s_at 0.2639 0.5836
GSE20347 TNFRSF1A 7132 207643_s_at 0.0592 0.7010
GSE23400 TNFRSF1A 7132 207643_s_at 0.1533 0.0104
GSE26886 TNFRSF1A 7132 207643_s_at -0.2483 0.2909
GSE29001 TNFRSF1A 7132 207643_s_at 0.2592 0.4975
GSE38129 TNFRSF1A 7132 207643_s_at 0.0143 0.9186
GSE45670 TNFRSF1A 7132 207643_s_at 0.3836 0.0062
GSE63941 TNFRSF1A 7132 207643_s_at -1.0178 0.0118
GSE77861 TNFRSF1A 7132 207643_s_at 0.3569 0.0557
GSE97050 TNFRSF1A 7132 A_23_P139722 0.0209 0.9259
SRP007169 TNFRSF1A 7132 RNAseq -0.1956 0.6248
SRP008496 TNFRSF1A 7132 RNAseq 0.1029 0.7320
SRP064894 TNFRSF1A 7132 RNAseq 0.2324 0.2900
SRP133303 TNFRSF1A 7132 RNAseq 0.3722 0.1048
SRP159526 TNFRSF1A 7132 RNAseq -0.1354 0.6194
SRP193095 TNFRSF1A 7132 RNAseq 0.1637 0.1977
SRP219564 TNFRSF1A 7132 RNAseq 0.0341 0.9278
TCGA TNFRSF1A 7132 RNAseq 0.0650 0.1619

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by TNFRSF1A expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of TNFRSF1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TNFRSF1A 7132 9 3 18
GSE20123 TNFRSF1A 7132 9 3 18
GSE43470 TNFRSF1A 7132 8 3 32
GSE46452 TNFRSF1A 7132 10 1 48
GSE47630 TNFRSF1A 7132 12 2 26
GSE54993 TNFRSF1A 7132 1 10 59
GSE54994 TNFRSF1A 7132 10 2 41
GSE60625 TNFRSF1A 7132 0 1 10
GSE74703 TNFRSF1A 7132 7 2 27
GSE74704 TNFRSF1A 7132 5 2 13
TCGA TNFRSF1A 7132 40 6 50

Total number of gains: 111; Total number of losses: 35; Total Number of normals: 342.  

 

Somatic mutations of TNFRSF1A:

 

Generating mutation plots.

 

Highly correlated genes for TNFRSF1A:

 

Showing top 20/513 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TNFRSF1ABABAM10.797778303
TNFRSF1ATMEM185B0.79398303
TNFRSF1ARTN4R0.786891404
TNFRSF1APUF600.784371303
TNFRSF1ADPYSL20.78297303
TNFRSF1ANCSTN0.781942303
TNFRSF1ATMEM63B0.77657303
TNFRSF1AFAM32A0.758938303
TNFRSF1AKLF130.75494303
TNFRSF1AHEATR60.753203303
TNFRSF1APLXNA10.750237303
TNFRSF1ACPT1A0.749525303
TNFRSF1AABCB60.748578303
TNFRSF1ACNRIP10.745433303
TNFRSF1AWDYHV10.744696303
TNFRSF1ACCM20.742805303
TNFRSF1ARHBDD20.741639303
TNFRSF1AGTF2E10.733546303
TNFRSF1AGLE10.733543303
TNFRSF1ARFTN10.727883303

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