| Full name: mitochondrial ribosomal protein L10 | Alias Symbol: RPML8|MRP-L8|L10MT|MRP-L10|MRPL8|MGC17973 | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 124995 | HGNC ID: HGNC:14055 | Ensembl Gene: ENSG00000159111 | OMIM ID: 611825 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL10 | 124995 | 224671_at | -0.0875 | 0.8880 | |
| GSE26886 | MRPL10 | 124995 | 224671_at | -0.1102 | 0.6491 | |
| GSE45670 | MRPL10 | 124995 | 224671_at | -0.1020 | 0.4989 | |
| GSE53622 | MRPL10 | 124995 | 158286 | 0.4921 | 0.0002 | |
| GSE53624 | MRPL10 | 124995 | 158286 | 0.4855 | 0.0000 | |
| GSE63941 | MRPL10 | 124995 | 224671_at | 0.9897 | 0.0138 | |
| GSE77861 | MRPL10 | 124995 | 224671_at | 0.3316 | 0.0612 | |
| GSE97050 | MRPL10 | 124995 | A_23_P218423 | 0.0205 | 0.9343 | |
| SRP007169 | MRPL10 | 124995 | RNAseq | -0.2287 | 0.5016 | |
| SRP008496 | MRPL10 | 124995 | RNAseq | -0.0752 | 0.7413 | |
| SRP064894 | MRPL10 | 124995 | RNAseq | 0.1246 | 0.4851 | |
| SRP133303 | MRPL10 | 124995 | RNAseq | 0.0698 | 0.5674 | |
| SRP159526 | MRPL10 | 124995 | RNAseq | 0.0351 | 0.8530 | |
| SRP193095 | MRPL10 | 124995 | RNAseq | 0.2008 | 0.0763 | |
| SRP219564 | MRPL10 | 124995 | RNAseq | 0.2117 | 0.6541 | |
| TCGA | MRPL10 | 124995 | RNAseq | -0.0552 | 0.2581 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPL10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL10 | 124995 | 5 | 2 | 23 | |
| GSE20123 | MRPL10 | 124995 | 5 | 2 | 23 | |
| GSE43470 | MRPL10 | 124995 | 1 | 2 | 40 | |
| GSE46452 | MRPL10 | 124995 | 32 | 0 | 27 | |
| GSE47630 | MRPL10 | 124995 | 9 | 0 | 31 | |
| GSE54993 | MRPL10 | 124995 | 2 | 4 | 64 | |
| GSE54994 | MRPL10 | 124995 | 11 | 5 | 37 | |
| GSE60625 | MRPL10 | 124995 | 4 | 0 | 7 | |
| GSE74703 | MRPL10 | 124995 | 1 | 1 | 34 | |
| GSE74704 | MRPL10 | 124995 | 4 | 1 | 15 | |
| TCGA | MRPL10 | 124995 | 28 | 6 | 62 |
Total number of gains: 102; Total number of losses: 23; Total Number of normals: 363.
Somatic mutations of MRPL10:
Generating mutation plots.
Highly correlated genes for MRPL10:
Showing top 20/442 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL10 | MAP1LC3B | 0.787997 | 3 | 0 | 3 |
| MRPL10 | ZDHHC4 | 0.778715 | 3 | 0 | 3 |
| MRPL10 | SSR3 | 0.767341 | 3 | 0 | 3 |
| MRPL10 | ZCCHC8 | 0.749942 | 3 | 0 | 3 |
| MRPL10 | TTI2 | 0.748427 | 3 | 0 | 3 |
| MRPL10 | METTL22 | 0.743056 | 3 | 0 | 3 |
| MRPL10 | SLC25A24 | 0.736998 | 3 | 0 | 3 |
| MRPL10 | NRARP | 0.734237 | 3 | 0 | 3 |
| MRPL10 | GTF2E1 | 0.733303 | 3 | 0 | 3 |
| MRPL10 | ARL2BP | 0.732985 | 4 | 0 | 3 |
| MRPL10 | EIF3F | 0.732405 | 3 | 0 | 3 |
| MRPL10 | THAP10 | 0.730745 | 3 | 0 | 3 |
| MRPL10 | CD2BP2 | 0.727548 | 3 | 0 | 3 |
| MRPL10 | FTO | 0.727341 | 4 | 0 | 3 |
| MRPL10 | ATP9A | 0.726934 | 3 | 0 | 3 |
| MRPL10 | PACSIN2 | 0.725051 | 3 | 0 | 3 |
| MRPL10 | RHOU | 0.722203 | 3 | 0 | 3 |
| MRPL10 | RAP1B | 0.719229 | 4 | 0 | 3 |
| MRPL10 | LYRM4 | 0.718419 | 3 | 0 | 3 |
| MRPL10 | C12orf4 | 0.71533 | 3 | 0 | 3 |
For details and further investigation, click here
