| Full name: protein phosphatase 4 regulatory subunit 1 | Alias Symbol: PP4R1 | ||
| Type: protein-coding gene | Cytoband: 18p11.22 | ||
| Entrez ID: 9989 | HGNC ID: HGNC:9320 | Ensembl Gene: ENSG00000154845 | OMIM ID: 604908 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPP4R1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP4R1 | 9989 | 201594_s_at | -0.3567 | 0.7107 | |
| GSE20347 | PPP4R1 | 9989 | 201594_s_at | -0.6439 | 0.0001 | |
| GSE23400 | PPP4R1 | 9989 | 201594_s_at | -0.4604 | 0.0000 | |
| GSE26886 | PPP4R1 | 9989 | 201594_s_at | -1.1125 | 0.0000 | |
| GSE29001 | PPP4R1 | 9989 | 201594_s_at | -0.3846 | 0.0365 | |
| GSE38129 | PPP4R1 | 9989 | 201594_s_at | -0.2791 | 0.2802 | |
| GSE45670 | PPP4R1 | 9989 | 201594_s_at | -0.0138 | 0.9537 | |
| GSE53622 | PPP4R1 | 9989 | 51736 | -0.4755 | 0.0001 | |
| GSE53624 | PPP4R1 | 9989 | 51736 | -0.8410 | 0.0000 | |
| GSE63941 | PPP4R1 | 9989 | 201594_s_at | -0.1487 | 0.8380 | |
| GSE77861 | PPP4R1 | 9989 | 201594_s_at | -0.4688 | 0.0896 | |
| GSE97050 | PPP4R1 | 9989 | A_24_P271014 | -0.1661 | 0.8147 | |
| SRP007169 | PPP4R1 | 9989 | RNAseq | -1.6610 | 0.0000 | |
| SRP008496 | PPP4R1 | 9989 | RNAseq | -1.8385 | 0.0000 | |
| SRP064894 | PPP4R1 | 9989 | RNAseq | -0.7788 | 0.0013 | |
| SRP133303 | PPP4R1 | 9989 | RNAseq | -0.1567 | 0.4390 | |
| SRP159526 | PPP4R1 | 9989 | RNAseq | -1.0785 | 0.0003 | |
| SRP193095 | PPP4R1 | 9989 | RNAseq | -0.5697 | 0.0042 | |
| SRP219564 | PPP4R1 | 9989 | RNAseq | -1.3201 | 0.0056 | |
| TCGA | PPP4R1 | 9989 | RNAseq | 0.0985 | 0.1082 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PPP4R1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP4R1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP4R1 | 9989 | 6 | 3 | 21 | |
| GSE20123 | PPP4R1 | 9989 | 6 | 3 | 21 | |
| GSE43470 | PPP4R1 | 9989 | 3 | 6 | 34 | |
| GSE46452 | PPP4R1 | 9989 | 3 | 21 | 35 | |
| GSE47630 | PPP4R1 | 9989 | 7 | 17 | 16 | |
| GSE54993 | PPP4R1 | 9989 | 6 | 2 | 62 | |
| GSE54994 | PPP4R1 | 9989 | 8 | 8 | 37 | |
| GSE60625 | PPP4R1 | 9989 | 0 | 4 | 7 | |
| GSE74703 | PPP4R1 | 9989 | 2 | 4 | 30 | |
| GSE74704 | PPP4R1 | 9989 | 4 | 2 | 14 | |
| TCGA | PPP4R1 | 9989 | 29 | 23 | 44 |
Total number of gains: 74; Total number of losses: 93; Total Number of normals: 321.
Somatic mutations of PPP4R1:
Generating mutation plots.
Highly correlated genes for PPP4R1:
Showing top 20/1413 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP4R1 | SLU7 | 0.780779 | 3 | 0 | 3 |
| PPP4R1 | CEPT1 | 0.776833 | 4 | 0 | 4 |
| PPP4R1 | GTF3C6 | 0.770732 | 3 | 0 | 3 |
| PPP4R1 | GPBP1 | 0.761011 | 3 | 0 | 3 |
| PPP4R1 | ZNF879 | 0.760305 | 3 | 0 | 3 |
| PPP4R1 | STK40 | 0.755073 | 3 | 0 | 3 |
| PPP4R1 | HMGN1 | 0.753469 | 3 | 0 | 3 |
| PPP4R1 | MAT2B | 0.752519 | 3 | 0 | 3 |
| PPP4R1 | EIF4E3 | 0.743642 | 3 | 0 | 3 |
| PPP4R1 | ANKRD37 | 0.74187 | 4 | 0 | 4 |
| PPP4R1 | MRPL35 | 0.735045 | 3 | 0 | 3 |
| PPP4R1 | FRMD4B | 0.734394 | 11 | 0 | 11 |
| PPP4R1 | COMMD10 | 0.729639 | 4 | 0 | 4 |
| PPP4R1 | RBM5 | 0.72666 | 3 | 0 | 3 |
| PPP4R1 | TIFA | 0.726496 | 3 | 0 | 3 |
| PPP4R1 | PEX19 | 0.721231 | 3 | 0 | 3 |
| PPP4R1 | RABGGTA | 0.719067 | 10 | 0 | 10 |
| PPP4R1 | DCTN4 | 0.716152 | 4 | 0 | 3 |
| PPP4R1 | COMMD1 | 0.715645 | 3 | 0 | 3 |
| PPP4R1 | SMN2 | 0.715089 | 3 | 0 | 3 |
For details and further investigation, click here
