| Full name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 | Alias Symbol: FLJ10659|DIP13B | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 55198 | HGNC ID: HGNC:18242 | Ensembl Gene: ENSG00000136044 | OMIM ID: 606231 |
| Drug and gene relationship at DGIdb | |||
Expression of APPL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APPL2 | 55198 | 218218_at | -0.0356 | 0.9676 | |
| GSE20347 | APPL2 | 55198 | 218218_at | -0.0925 | 0.6752 | |
| GSE23400 | APPL2 | 55198 | 218218_at | 0.1883 | 0.0202 | |
| GSE26886 | APPL2 | 55198 | 218218_at | -0.4834 | 0.1698 | |
| GSE29001 | APPL2 | 55198 | 218218_at | -0.1824 | 0.6170 | |
| GSE38129 | APPL2 | 55198 | 218218_at | 0.1694 | 0.3819 | |
| GSE45670 | APPL2 | 55198 | 218218_at | -0.1136 | 0.6483 | |
| GSE53622 | APPL2 | 55198 | 83957 | 0.1256 | 0.1178 | |
| GSE53624 | APPL2 | 55198 | 83957 | -0.1798 | 0.0100 | |
| GSE63941 | APPL2 | 55198 | 218218_at | 0.3833 | 0.4217 | |
| GSE77861 | APPL2 | 55198 | 218218_at | 0.1662 | 0.6894 | |
| GSE97050 | APPL2 | 55198 | A_23_P105747 | 0.2008 | 0.4753 | |
| SRP007169 | APPL2 | 55198 | RNAseq | -0.2231 | 0.5171 | |
| SRP008496 | APPL2 | 55198 | RNAseq | 0.0231 | 0.9155 | |
| SRP064894 | APPL2 | 55198 | RNAseq | 0.0103 | 0.9591 | |
| SRP133303 | APPL2 | 55198 | RNAseq | 0.0848 | 0.6813 | |
| SRP159526 | APPL2 | 55198 | RNAseq | 0.4608 | 0.0754 | |
| SRP193095 | APPL2 | 55198 | RNAseq | -0.0764 | 0.5164 | |
| SRP219564 | APPL2 | 55198 | RNAseq | -0.3779 | 0.3351 | |
| TCGA | APPL2 | 55198 | RNAseq | -0.1418 | 0.0091 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by APPL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APPL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APPL2 | 55198 | 4 | 2 | 24 | |
| GSE20123 | APPL2 | 55198 | 4 | 2 | 24 | |
| GSE43470 | APPL2 | 55198 | 2 | 0 | 41 | |
| GSE46452 | APPL2 | 55198 | 9 | 1 | 49 | |
| GSE47630 | APPL2 | 55198 | 9 | 1 | 30 | |
| GSE54993 | APPL2 | 55198 | 0 | 5 | 65 | |
| GSE54994 | APPL2 | 55198 | 4 | 2 | 47 | |
| GSE60625 | APPL2 | 55198 | 0 | 0 | 11 | |
| GSE74703 | APPL2 | 55198 | 2 | 0 | 34 | |
| GSE74704 | APPL2 | 55198 | 1 | 2 | 17 | |
| TCGA | APPL2 | 55198 | 19 | 10 | 67 |
Total number of gains: 54; Total number of losses: 25; Total Number of normals: 409.
Somatic mutations of APPL2:
Generating mutation plots.
Highly correlated genes for APPL2:
Showing top 20/403 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APPL2 | MRPL35 | 0.76781 | 3 | 0 | 3 |
| APPL2 | SERPINB8 | 0.765288 | 3 | 0 | 3 |
| APPL2 | TRIP4 | 0.754059 | 3 | 0 | 3 |
| APPL2 | NAA20 | 0.753848 | 3 | 0 | 3 |
| APPL2 | DRAM2 | 0.752993 | 3 | 0 | 3 |
| APPL2 | PEX2 | 0.746559 | 3 | 0 | 3 |
| APPL2 | TTC23 | 0.740669 | 3 | 0 | 3 |
| APPL2 | BTBD1 | 0.736656 | 3 | 0 | 3 |
| APPL2 | WDR36 | 0.73301 | 3 | 0 | 3 |
| APPL2 | HSDL1 | 0.726615 | 3 | 0 | 3 |
| APPL2 | SGMS1 | 0.72579 | 3 | 0 | 3 |
| APPL2 | BMPR2 | 0.722422 | 3 | 0 | 3 |
| APPL2 | TXNDC16 | 0.718701 | 3 | 0 | 3 |
| APPL2 | AIFM1 | 0.70567 | 4 | 0 | 4 |
| APPL2 | ZNF770 | 0.700667 | 3 | 0 | 3 |
| APPL2 | TAF12 | 0.69623 | 4 | 0 | 3 |
| APPL2 | FBXO8 | 0.692468 | 3 | 0 | 3 |
| APPL2 | SAP30L | 0.692457 | 3 | 0 | 3 |
| APPL2 | EGLN1 | 0.692133 | 3 | 0 | 3 |
| APPL2 | C12orf29 | 0.691784 | 3 | 0 | 3 |
For details and further investigation, click here
