| Full name: transmembrane and coiled-coil domain family 3 | Alias Symbol: KIAA1145 | ||
| Type: protein-coding gene | Cytoband: 12q22 | ||
| Entrez ID: 57458 | HGNC ID: HGNC:29199 | Ensembl Gene: ENSG00000057704 | OMIM ID: 617459 |
| Drug and gene relationship at DGIdb | |||
Expression of TMCC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMCC3 | 57458 | 235146_at | -0.1639 | 0.8558 | |
| GSE26886 | TMCC3 | 57458 | 235146_at | -0.6742 | 0.1014 | |
| GSE45670 | TMCC3 | 57458 | 235146_at | 0.4648 | 0.0911 | |
| GSE53622 | TMCC3 | 57458 | 55526 | -0.2309 | 0.0921 | |
| GSE53624 | TMCC3 | 57458 | 55526 | -0.2350 | 0.0209 | |
| GSE63941 | TMCC3 | 57458 | 226489_at | 2.0215 | 0.0167 | |
| GSE77861 | TMCC3 | 57458 | 226489_at | 0.0446 | 0.8669 | |
| GSE97050 | TMCC3 | 57458 | A_24_P305933 | 0.0802 | 0.7698 | |
| SRP007169 | TMCC3 | 57458 | RNAseq | -0.2010 | 0.6818 | |
| SRP008496 | TMCC3 | 57458 | RNAseq | 0.0052 | 0.9896 | |
| SRP064894 | TMCC3 | 57458 | RNAseq | -0.1533 | 0.5028 | |
| SRP133303 | TMCC3 | 57458 | RNAseq | 0.1242 | 0.6066 | |
| SRP159526 | TMCC3 | 57458 | RNAseq | -0.5856 | 0.3254 | |
| SRP193095 | TMCC3 | 57458 | RNAseq | -0.0771 | 0.6818 | |
| SRP219564 | TMCC3 | 57458 | RNAseq | -0.3797 | 0.4308 | |
| TCGA | TMCC3 | 57458 | RNAseq | -0.0543 | 0.6308 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TMCC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMCC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMCC3 | 57458 | 4 | 2 | 24 | |
| GSE20123 | TMCC3 | 57458 | 4 | 2 | 24 | |
| GSE43470 | TMCC3 | 57458 | 3 | 0 | 40 | |
| GSE46452 | TMCC3 | 57458 | 9 | 1 | 49 | |
| GSE47630 | TMCC3 | 57458 | 9 | 1 | 30 | |
| GSE54993 | TMCC3 | 57458 | 0 | 5 | 65 | |
| GSE54994 | TMCC3 | 57458 | 4 | 1 | 48 | |
| GSE60625 | TMCC3 | 57458 | 0 | 0 | 11 | |
| GSE74703 | TMCC3 | 57458 | 3 | 0 | 33 | |
| GSE74704 | TMCC3 | 57458 | 1 | 2 | 17 | |
| TCGA | TMCC3 | 57458 | 17 | 10 | 69 |
Total number of gains: 54; Total number of losses: 24; Total Number of normals: 410.
Somatic mutations of TMCC3:
Generating mutation plots.
Highly correlated genes for TMCC3:
Showing top 20/273 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMCC3 | CDK5RAP2 | 0.825691 | 3 | 0 | 3 |
| TMCC3 | USP40 | 0.80622 | 3 | 0 | 3 |
| TMCC3 | TRMT1L | 0.796911 | 3 | 0 | 3 |
| TMCC3 | CCNYL1 | 0.770136 | 3 | 0 | 3 |
| TMCC3 | CMTM4 | 0.76234 | 3 | 0 | 3 |
| TMCC3 | ANKRD13C | 0.759687 | 3 | 0 | 3 |
| TMCC3 | MCTP1 | 0.756772 | 3 | 0 | 3 |
| TMCC3 | MYO1D | 0.75072 | 3 | 0 | 3 |
| TMCC3 | EIF4E2 | 0.741883 | 3 | 0 | 3 |
| TMCC3 | ITPR3 | 0.741477 | 3 | 0 | 3 |
| TMCC3 | RPE | 0.730875 | 3 | 0 | 3 |
| TMCC3 | DDX52 | 0.72767 | 3 | 0 | 3 |
| TMCC3 | MRPL35 | 0.727592 | 3 | 0 | 3 |
| TMCC3 | DNAJA2 | 0.727095 | 3 | 0 | 3 |
| TMCC3 | PTPN12 | 0.726268 | 3 | 0 | 3 |
| TMCC3 | VEZT | 0.723486 | 3 | 0 | 3 |
| TMCC3 | RAB12 | 0.7187 | 3 | 0 | 3 |
| TMCC3 | RSL1D1 | 0.715103 | 3 | 0 | 3 |
| TMCC3 | FNDC8 | 0.710567 | 3 | 0 | 3 |
| TMCC3 | RB1 | 0.709148 | 3 | 0 | 3 |
For details and further investigation, click here
