| Full name: mitochondrial ribosomal protein L48 | Alias Symbol: CGI-118 | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 51642 | HGNC ID: HGNC:16653 | Ensembl Gene: ENSG00000175581 | OMIM ID: 611853 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPL48:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL48 | 51642 | 218281_at | 0.2045 | 0.7927 | |
| GSE20347 | MRPL48 | 51642 | 218281_at | 0.1510 | 0.4458 | |
| GSE23400 | MRPL48 | 51642 | 218281_at | 0.3682 | 0.0001 | |
| GSE26886 | MRPL48 | 51642 | 218281_at | 0.5766 | 0.0333 | |
| GSE29001 | MRPL48 | 51642 | 218281_at | -0.0309 | 0.9582 | |
| GSE38129 | MRPL48 | 51642 | 218281_at | 0.2608 | 0.0411 | |
| GSE45670 | MRPL48 | 51642 | 218281_at | 0.2728 | 0.2865 | |
| GSE53622 | MRPL48 | 51642 | 39351 | -0.0275 | 0.7884 | |
| GSE53624 | MRPL48 | 51642 | 39351 | 0.2824 | 0.0003 | |
| GSE63941 | MRPL48 | 51642 | 218281_at | 1.1697 | 0.0412 | |
| GSE77861 | MRPL48 | 51642 | 218281_at | -0.0037 | 0.9933 | |
| GSE97050 | MRPL48 | 51642 | A_23_P162106 | -0.0259 | 0.9410 | |
| SRP007169 | MRPL48 | 51642 | RNAseq | -0.2282 | 0.5727 | |
| SRP008496 | MRPL48 | 51642 | RNAseq | -0.0134 | 0.9721 | |
| SRP064894 | MRPL48 | 51642 | RNAseq | 0.1305 | 0.5648 | |
| SRP133303 | MRPL48 | 51642 | RNAseq | 0.0708 | 0.7759 | |
| SRP159526 | MRPL48 | 51642 | RNAseq | -0.2330 | 0.3926 | |
| SRP193095 | MRPL48 | 51642 | RNAseq | 0.0470 | 0.7882 | |
| SRP219564 | MRPL48 | 51642 | RNAseq | 0.3060 | 0.4628 | |
| TCGA | MRPL48 | 51642 | RNAseq | 0.2103 | 0.0181 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MRPL48 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL48:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL48 | 51642 | 5 | 9 | 16 | |
| GSE20123 | MRPL48 | 51642 | 5 | 8 | 17 | |
| GSE43470 | MRPL48 | 51642 | 6 | 4 | 33 | |
| GSE46452 | MRPL48 | 51642 | 9 | 20 | 30 | |
| GSE47630 | MRPL48 | 51642 | 6 | 14 | 20 | |
| GSE54993 | MRPL48 | 51642 | 8 | 3 | 59 | |
| GSE54994 | MRPL48 | 51642 | 8 | 15 | 30 | |
| GSE60625 | MRPL48 | 51642 | 0 | 7 | 4 | |
| GSE74703 | MRPL48 | 51642 | 5 | 3 | 28 | |
| GSE74704 | MRPL48 | 51642 | 3 | 4 | 13 | |
| TCGA | MRPL48 | 51642 | 28 | 27 | 41 |
Total number of gains: 83; Total number of losses: 114; Total Number of normals: 291.
Somatic mutations of MRPL48:
Generating mutation plots.
Highly correlated genes for MRPL48:
Showing top 20/337 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL48 | COA4 | 0.799722 | 11 | 0 | 11 |
| MRPL48 | CASP4 | 0.769916 | 3 | 0 | 3 |
| MRPL48 | TCEA1 | 0.767706 | 3 | 0 | 3 |
| MRPL48 | SNAPC5 | 0.748638 | 3 | 0 | 3 |
| MRPL48 | MIPOL1 | 0.742888 | 3 | 0 | 3 |
| MRPL48 | CORO1C | 0.739024 | 3 | 0 | 3 |
| MRPL48 | C11orf74 | 0.731954 | 3 | 0 | 3 |
| MRPL48 | ZNF300 | 0.728569 | 3 | 0 | 3 |
| MRPL48 | GPD2 | 0.727523 | 3 | 0 | 3 |
| MRPL48 | CDK9 | 0.724058 | 3 | 0 | 3 |
| MRPL48 | OPLAH | 0.722218 | 3 | 0 | 3 |
| MRPL48 | THUMPD1 | 0.715729 | 3 | 0 | 3 |
| MRPL48 | POMZP3 | 0.712487 | 3 | 0 | 3 |
| MRPL48 | ZBTB37 | 0.709195 | 3 | 0 | 3 |
| MRPL48 | RBMX | 0.708056 | 3 | 0 | 3 |
| MRPL48 | MLH1 | 0.695601 | 3 | 0 | 3 |
| MRPL48 | MIA3 | 0.694282 | 3 | 0 | 3 |
| MRPL48 | SLC39A10 | 0.692788 | 3 | 0 | 3 |
| MRPL48 | LRRC58 | 0.6905 | 3 | 0 | 3 |
| MRPL48 | THUMPD3 | 0.688151 | 3 | 0 | 3 |
For details and further investigation, click here
