| Full name: caspase 4 | Alias Symbol: ICE(rel)II|ICH-2|TX | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 837 | HGNC ID: HGNC:1505 | Ensembl Gene: ENSG00000196954 | OMIM ID: 602664 |
| Drug and gene relationship at DGIdb | |||
Expression of CASP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASP4 | 837 | 209310_s_at | -0.1505 | 0.8842 | |
| GSE20347 | CASP4 | 837 | 209310_s_at | -1.0657 | 0.0002 | |
| GSE23400 | CASP4 | 837 | 209310_s_at | -0.2139 | 0.0129 | |
| GSE26886 | CASP4 | 837 | 209310_s_at | -0.3763 | 0.2093 | |
| GSE29001 | CASP4 | 837 | 209310_s_at | -0.7749 | 0.1523 | |
| GSE38129 | CASP4 | 837 | 209310_s_at | -0.5425 | 0.0168 | |
| GSE45670 | CASP4 | 837 | 209310_s_at | 0.3056 | 0.1907 | |
| GSE53622 | CASP4 | 837 | 57737 | -0.1419 | 0.1827 | |
| GSE53624 | CASP4 | 837 | 57737 | -0.3546 | 0.0000 | |
| GSE63941 | CASP4 | 837 | 209310_s_at | -1.0348 | 0.1520 | |
| GSE77861 | CASP4 | 837 | 209310_s_at | -0.5542 | 0.0641 | |
| GSE97050 | CASP4 | 837 | A_23_P35912 | 0.2543 | 0.4471 | |
| SRP007169 | CASP4 | 837 | RNAseq | -2.0978 | 0.0000 | |
| SRP008496 | CASP4 | 837 | RNAseq | -2.1546 | 0.0000 | |
| SRP064894 | CASP4 | 837 | RNAseq | -0.5612 | 0.0014 | |
| SRP133303 | CASP4 | 837 | RNAseq | -0.4485 | 0.0061 | |
| SRP159526 | CASP4 | 837 | RNAseq | -1.1016 | 0.0440 | |
| SRP193095 | CASP4 | 837 | RNAseq | -0.8329 | 0.0000 | |
| SRP219564 | CASP4 | 837 | RNAseq | -0.4525 | 0.3510 | |
| TCGA | CASP4 | 837 | RNAseq | 0.0778 | 0.3935 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by CASP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASP4 | 837 | 1 | 11 | 18 | |
| GSE20123 | CASP4 | 837 | 1 | 11 | 18 | |
| GSE43470 | CASP4 | 837 | 3 | 6 | 34 | |
| GSE46452 | CASP4 | 837 | 3 | 26 | 30 | |
| GSE47630 | CASP4 | 837 | 2 | 19 | 19 | |
| GSE54993 | CASP4 | 837 | 9 | 1 | 60 | |
| GSE54994 | CASP4 | 837 | 4 | 19 | 30 | |
| GSE60625 | CASP4 | 837 | 0 | 3 | 8 | |
| GSE74703 | CASP4 | 837 | 2 | 4 | 30 | |
| GSE74704 | CASP4 | 837 | 1 | 7 | 12 | |
| TCGA | CASP4 | 837 | 9 | 44 | 43 |
Total number of gains: 35; Total number of losses: 151; Total Number of normals: 302.
Somatic mutations of CASP4:
Generating mutation plots.
Highly correlated genes for CASP4:
Showing top 20/879 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASP4 | MRPS11 | 0.775844 | 3 | 0 | 3 |
| CASP4 | MRPL48 | 0.769916 | 3 | 0 | 3 |
| CASP4 | ROBO1 | 0.769192 | 3 | 0 | 3 |
| CASP4 | CASP1 | 0.76564 | 13 | 0 | 12 |
| CASP4 | EIF3I | 0.763496 | 4 | 0 | 3 |
| CASP4 | ATG2B | 0.762181 | 3 | 0 | 3 |
| CASP4 | ALG5 | 0.757976 | 3 | 0 | 3 |
| CASP4 | HDHD2 | 0.751286 | 3 | 0 | 3 |
| CASP4 | SEC11C | 0.751183 | 3 | 0 | 3 |
| CASP4 | HEATR5B | 0.743888 | 3 | 0 | 3 |
| CASP4 | APOOL | 0.742328 | 3 | 0 | 3 |
| CASP4 | HSPA9 | 0.738675 | 3 | 0 | 3 |
| CASP4 | TMEM186 | 0.71876 | 3 | 0 | 3 |
| CASP4 | RTN4IP1 | 0.71237 | 3 | 0 | 3 |
| CASP4 | CPVL | 0.710978 | 4 | 0 | 3 |
| CASP4 | ECHDC1 | 0.710926 | 3 | 0 | 3 |
| CASP4 | TMEM126A | 0.71071 | 5 | 0 | 4 |
| CASP4 | MOB4 | 0.708933 | 3 | 0 | 3 |
| CASP4 | TAX1BP3 | 0.708789 | 3 | 0 | 3 |
| CASP4 | FAM83G | 0.705129 | 3 | 0 | 3 |
For details and further investigation, click here
