| Full name: cyclin dependent kinase 9 | Alias Symbol: PITALRE|C-2k|TAK | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 1025 | HGNC ID: HGNC:1780 | Ensembl Gene: ENSG00000136807 | OMIM ID: 603251 |
| Drug and gene relationship at DGIdb | |||
Expression of CDK9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK9 | 1025 | 203198_at | 0.1927 | 0.6880 | |
| GSE20347 | CDK9 | 1025 | 203198_at | -0.0311 | 0.8233 | |
| GSE23400 | CDK9 | 1025 | 203198_at | 0.0733 | 0.3714 | |
| GSE26886 | CDK9 | 1025 | 203198_at | -0.7157 | 0.0049 | |
| GSE29001 | CDK9 | 1025 | 203198_at | -0.0957 | 0.6336 | |
| GSE38129 | CDK9 | 1025 | 203198_at | 0.0060 | 0.9829 | |
| GSE45670 | CDK9 | 1025 | 203198_at | 0.0244 | 0.8911 | |
| GSE53622 | CDK9 | 1025 | 147722 | -0.1889 | 0.0091 | |
| GSE53624 | CDK9 | 1025 | 147722 | 0.1934 | 0.0014 | |
| GSE63941 | CDK9 | 1025 | 203198_at | 0.2497 | 0.5356 | |
| GSE77861 | CDK9 | 1025 | 203198_at | 0.2944 | 0.1606 | |
| GSE97050 | CDK9 | 1025 | A_23_P169470 | -0.0647 | 0.8023 | |
| SRP007169 | CDK9 | 1025 | RNAseq | 0.0752 | 0.8532 | |
| SRP008496 | CDK9 | 1025 | RNAseq | 0.2299 | 0.4213 | |
| SRP064894 | CDK9 | 1025 | RNAseq | 0.2863 | 0.1545 | |
| SRP133303 | CDK9 | 1025 | RNAseq | 0.0356 | 0.8313 | |
| SRP159526 | CDK9 | 1025 | RNAseq | -0.1723 | 0.4087 | |
| SRP193095 | CDK9 | 1025 | RNAseq | 0.1395 | 0.0940 | |
| SRP219564 | CDK9 | 1025 | RNAseq | -0.0301 | 0.9024 | |
| TCGA | CDK9 | 1025 | RNAseq | 0.0644 | 0.1950 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDK9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK9 | 1025 | 6 | 9 | 15 | |
| GSE20123 | CDK9 | 1025 | 6 | 9 | 15 | |
| GSE43470 | CDK9 | 1025 | 5 | 6 | 32 | |
| GSE46452 | CDK9 | 1025 | 6 | 13 | 40 | |
| GSE47630 | CDK9 | 1025 | 3 | 16 | 21 | |
| GSE54993 | CDK9 | 1025 | 3 | 3 | 64 | |
| GSE54994 | CDK9 | 1025 | 11 | 8 | 34 | |
| GSE60625 | CDK9 | 1025 | 0 | 0 | 11 | |
| GSE74703 | CDK9 | 1025 | 5 | 4 | 27 | |
| GSE74704 | CDK9 | 1025 | 3 | 7 | 10 | |
| TCGA | CDK9 | 1025 | 27 | 25 | 44 |
Total number of gains: 75; Total number of losses: 100; Total Number of normals: 313.
Somatic mutations of CDK9:
Generating mutation plots.
Highly correlated genes for CDK9:
Showing top 20/256 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK9 | GLUD1 | 0.759088 | 3 | 0 | 3 |
| CDK9 | VPS8 | 0.757664 | 3 | 0 | 3 |
| CDK9 | DCTN1 | 0.75699 | 3 | 0 | 3 |
| CDK9 | MRPL48 | 0.724058 | 3 | 0 | 3 |
| CDK9 | DEXI | 0.717445 | 3 | 0 | 3 |
| CDK9 | NUFIP2 | 0.71703 | 3 | 0 | 3 |
| CDK9 | ZFPL1 | 0.715182 | 4 | 0 | 3 |
| CDK9 | ARHGAP17 | 0.706099 | 4 | 0 | 4 |
| CDK9 | ABCB6 | 0.705652 | 4 | 0 | 4 |
| CDK9 | MTCP1 | 0.701594 | 3 | 0 | 3 |
| CDK9 | PKN1 | 0.697712 | 3 | 0 | 3 |
| CDK9 | POLN | 0.695229 | 3 | 0 | 3 |
| CDK9 | ZNF609 | 0.694696 | 3 | 0 | 3 |
| CDK9 | RALBP1 | 0.693194 | 3 | 0 | 3 |
| CDK9 | RTN4R | 0.689802 | 3 | 0 | 3 |
| CDK9 | HNRNPL | 0.689318 | 5 | 0 | 3 |
| CDK9 | LEPROT | 0.685364 | 4 | 0 | 4 |
| CDK9 | TNFRSF1A | 0.684844 | 3 | 0 | 3 |
| CDK9 | RTKN | 0.679408 | 3 | 0 | 3 |
| CDK9 | SLC31A2 | 0.673694 | 3 | 0 | 3 |
For details and further investigation, click here
