| Full name: tau tubulin kinase 2 | Alias Symbol: KIAA0847 | ||
| Type: protein-coding gene | Cytoband: 15q15.2 | ||
| Entrez ID: 146057 | HGNC ID: HGNC:19141 | Ensembl Gene: ENSG00000128881 | OMIM ID: 611695 |
| Drug and gene relationship at DGIdb | |||
Expression of TTBK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTBK2 | 146057 | 226964_at | 0.1166 | 0.8564 | |
| GSE20347 | TTBK2 | 146057 | 213922_at | 0.4425 | 0.0105 | |
| GSE23400 | TTBK2 | 146057 | 213922_at | 0.1032 | 0.0140 | |
| GSE26886 | TTBK2 | 146057 | 213922_at | 0.8293 | 0.0363 | |
| GSE29001 | TTBK2 | 146057 | 213922_at | 0.2588 | 0.1776 | |
| GSE38129 | TTBK2 | 146057 | 213922_at | 0.2113 | 0.3859 | |
| GSE45670 | TTBK2 | 146057 | 1557073_s_at | -0.2122 | 0.3783 | |
| GSE53622 | TTBK2 | 146057 | 76373 | 0.0096 | 0.9213 | |
| GSE53624 | TTBK2 | 146057 | 76373 | 0.3860 | 0.0000 | |
| GSE63941 | TTBK2 | 146057 | 1557073_s_at | 0.3207 | 0.6655 | |
| GSE77861 | TTBK2 | 146057 | 1557073_s_at | 0.1757 | 0.2509 | |
| GSE97050 | TTBK2 | 146057 | A_33_P3215277 | -0.2243 | 0.3612 | |
| SRP007169 | TTBK2 | 146057 | RNAseq | 1.6665 | 0.0011 | |
| SRP008496 | TTBK2 | 146057 | RNAseq | 1.6895 | 0.0000 | |
| SRP064894 | TTBK2 | 146057 | RNAseq | 0.3069 | 0.1789 | |
| SRP133303 | TTBK2 | 146057 | RNAseq | 0.1328 | 0.2897 | |
| SRP159526 | TTBK2 | 146057 | RNAseq | 0.2755 | 0.4365 | |
| SRP193095 | TTBK2 | 146057 | RNAseq | 0.5736 | 0.0000 | |
| SRP219564 | TTBK2 | 146057 | RNAseq | -0.2066 | 0.6282 | |
| TCGA | TTBK2 | 146057 | RNAseq | -0.0022 | 0.9805 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TTBK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTBK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTBK2 | 146057 | 4 | 5 | 21 | |
| GSE20123 | TTBK2 | 146057 | 4 | 6 | 20 | |
| GSE43470 | TTBK2 | 146057 | 4 | 5 | 34 | |
| GSE46452 | TTBK2 | 146057 | 3 | 7 | 49 | |
| GSE47630 | TTBK2 | 146057 | 8 | 10 | 22 | |
| GSE54993 | TTBK2 | 146057 | 4 | 6 | 60 | |
| GSE54994 | TTBK2 | 146057 | 5 | 7 | 41 | |
| GSE60625 | TTBK2 | 146057 | 4 | 0 | 7 | |
| GSE74703 | TTBK2 | 146057 | 4 | 4 | 28 | |
| GSE74704 | TTBK2 | 146057 | 3 | 3 | 14 | |
| TCGA | TTBK2 | 146057 | 11 | 17 | 68 |
Total number of gains: 54; Total number of losses: 70; Total Number of normals: 364.
Somatic mutations of TTBK2:
Generating mutation plots.
Highly correlated genes for TTBK2:
Showing top 20/591 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTBK2 | NCS1 | 0.755844 | 3 | 0 | 3 |
| TTBK2 | C17orf75 | 0.73855 | 3 | 0 | 3 |
| TTBK2 | TMTC1 | 0.724896 | 5 | 0 | 4 |
| TTBK2 | KLHL11 | 0.724853 | 3 | 0 | 3 |
| TTBK2 | SNRPA1 | 0.714468 | 3 | 0 | 3 |
| TTBK2 | LCAT | 0.713613 | 3 | 0 | 3 |
| TTBK2 | ITGA1 | 0.71361 | 3 | 0 | 3 |
| TTBK2 | VPS39 | 0.712423 | 5 | 0 | 5 |
| TTBK2 | DDHD1 | 0.710723 | 3 | 0 | 3 |
| TTBK2 | PRKG2 | 0.706989 | 3 | 0 | 3 |
| TTBK2 | EIF1B | 0.704399 | 3 | 0 | 3 |
| TTBK2 | MRPL50 | 0.69825 | 3 | 0 | 3 |
| TTBK2 | TCF7L1 | 0.694446 | 4 | 0 | 3 |
| TTBK2 | MRPL32 | 0.69286 | 4 | 0 | 3 |
| TTBK2 | FAM168B | 0.692822 | 4 | 0 | 3 |
| TTBK2 | PDCL3 | 0.691895 | 3 | 0 | 3 |
| TTBK2 | DHRSX | 0.686599 | 3 | 0 | 3 |
| TTBK2 | QTRT1 | 0.685577 | 3 | 0 | 3 |
| TTBK2 | TIA1 | 0.685395 | 4 | 0 | 3 |
| TTBK2 | ANAPC5 | 0.678606 | 3 | 0 | 3 |
For details and further investigation, click here
