| Full name: phosphopantothenoylcysteine synthetase | Alias Symbol: FLJ11838 | ||
| Type: protein-coding gene | Cytoband: 1p34.2 | ||
| Entrez ID: 79717 | HGNC ID: HGNC:25686 | Ensembl Gene: ENSG00000127125 | OMIM ID: 609853 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPCS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPCS | 79717 | 218341_at | -0.2485 | 0.6680 | |
| GSE20347 | PPCS | 79717 | 218341_at | -0.4362 | 0.0001 | |
| GSE23400 | PPCS | 79717 | 218341_at | -0.0834 | 0.1227 | |
| GSE26886 | PPCS | 79717 | 218341_at | -0.4624 | 0.0268 | |
| GSE29001 | PPCS | 79717 | 218341_at | -0.4073 | 0.0999 | |
| GSE38129 | PPCS | 79717 | 218341_at | -0.2807 | 0.0031 | |
| GSE45670 | PPCS | 79717 | 218341_at | -0.1822 | 0.1910 | |
| GSE53622 | PPCS | 79717 | 173766 | -0.3730 | 0.0000 | |
| GSE53624 | PPCS | 79717 | 173766 | -0.4136 | 0.0000 | |
| GSE63941 | PPCS | 79717 | 218341_at | 0.2104 | 0.5307 | |
| GSE77861 | PPCS | 79717 | 218341_at | -0.4301 | 0.0137 | |
| GSE97050 | PPCS | 79717 | A_24_P19810 | -0.1822 | 0.5462 | |
| SRP007169 | PPCS | 79717 | RNAseq | -1.0527 | 0.0022 | |
| SRP008496 | PPCS | 79717 | RNAseq | -1.0700 | 0.0000 | |
| SRP064894 | PPCS | 79717 | RNAseq | -0.4045 | 0.0191 | |
| SRP133303 | PPCS | 79717 | RNAseq | -0.0315 | 0.8063 | |
| SRP159526 | PPCS | 79717 | RNAseq | -0.4141 | 0.0789 | |
| SRP193095 | PPCS | 79717 | RNAseq | -0.6332 | 0.0000 | |
| SRP219564 | PPCS | 79717 | RNAseq | -0.4004 | 0.2420 | |
| TCGA | PPCS | 79717 | RNAseq | -0.1395 | 0.0058 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PPCS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPCS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPCS | 79717 | 4 | 3 | 23 | |
| GSE20123 | PPCS | 79717 | 3 | 2 | 25 | |
| GSE43470 | PPCS | 79717 | 7 | 2 | 34 | |
| GSE46452 | PPCS | 79717 | 3 | 1 | 55 | |
| GSE47630 | PPCS | 79717 | 9 | 2 | 29 | |
| GSE54993 | PPCS | 79717 | 0 | 2 | 68 | |
| GSE54994 | PPCS | 79717 | 13 | 2 | 38 | |
| GSE60625 | PPCS | 79717 | 0 | 0 | 11 | |
| GSE74703 | PPCS | 79717 | 6 | 1 | 29 | |
| GSE74704 | PPCS | 79717 | 1 | 0 | 19 | |
| TCGA | PPCS | 79717 | 13 | 16 | 67 |
Total number of gains: 59; Total number of losses: 31; Total Number of normals: 398.
Somatic mutations of PPCS:
Generating mutation plots.
Highly correlated genes for PPCS:
Showing top 20/1062 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPCS | ZCCHC8 | 0.8298 | 3 | 0 | 3 |
| PPCS | PRPF38A | 0.813389 | 4 | 0 | 4 |
| PPCS | PPP1R8 | 0.783086 | 3 | 0 | 3 |
| PPCS | TLE4 | 0.780258 | 3 | 0 | 3 |
| PPCS | SPPL3 | 0.765055 | 3 | 0 | 3 |
| PPCS | MRPS18B | 0.761717 | 3 | 0 | 3 |
| PPCS | REPS1 | 0.760018 | 3 | 0 | 3 |
| PPCS | RAB1A | 0.746308 | 3 | 0 | 3 |
| PPCS | RBPJL | 0.74164 | 3 | 0 | 3 |
| PPCS | ZNF616 | 0.735705 | 3 | 0 | 3 |
| PPCS | CREBBP | 0.728129 | 3 | 0 | 3 |
| PPCS | CTCF | 0.721657 | 3 | 0 | 3 |
| PPCS | ZNF436 | 0.720705 | 6 | 0 | 5 |
| PPCS | ARL16 | 0.718867 | 3 | 0 | 3 |
| PPCS | FBXW5 | 0.715646 | 4 | 0 | 4 |
| PPCS | GPBP1 | 0.715483 | 3 | 0 | 3 |
| PPCS | HADHB | 0.714092 | 7 | 0 | 6 |
| PPCS | SEC23IP | 0.709615 | 3 | 0 | 3 |
| PPCS | SCP2 | 0.708865 | 11 | 0 | 11 |
| PPCS | UBE2G2 | 0.707533 | 3 | 0 | 3 |
For details and further investigation, click here
