| Full name: methyl-CpG binding domain protein 1 | Alias Symbol: PCM1|CXXC3 | ||
| Type: protein-coding gene | Cytoband: 18q21.1 | ||
| Entrez ID: 4152 | HGNC ID: HGNC:6916 | Ensembl Gene: ENSG00000141644 | OMIM ID: 156535 |
| Drug and gene relationship at DGIdb | |||
Expression of MBD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MBD1 | 4152 | 203353_s_at | -0.0917 | 0.8356 | |
| GSE20347 | MBD1 | 4152 | 203353_s_at | -0.1976 | 0.2789 | |
| GSE23400 | MBD1 | 4152 | 203353_s_at | -0.0312 | 0.5784 | |
| GSE26886 | MBD1 | 4152 | 203353_s_at | -0.5470 | 0.0193 | |
| GSE29001 | MBD1 | 4152 | 203353_s_at | -0.1153 | 0.6154 | |
| GSE38129 | MBD1 | 4152 | 203353_s_at | -0.1537 | 0.2355 | |
| GSE45670 | MBD1 | 4152 | 203353_s_at | 0.0447 | 0.8468 | |
| GSE53622 | MBD1 | 4152 | 13669 | -0.4257 | 0.0000 | |
| GSE53624 | MBD1 | 4152 | 13669 | -0.3215 | 0.0000 | |
| GSE63941 | MBD1 | 4152 | 203353_s_at | -1.3475 | 0.0534 | |
| GSE77861 | MBD1 | 4152 | 203353_s_at | -0.2458 | 0.3670 | |
| GSE97050 | MBD1 | 4152 | A_33_P3398922 | 0.0394 | 0.8733 | |
| SRP007169 | MBD1 | 4152 | RNAseq | -0.3769 | 0.2913 | |
| SRP008496 | MBD1 | 4152 | RNAseq | 0.1878 | 0.6356 | |
| SRP064894 | MBD1 | 4152 | RNAseq | 0.0980 | 0.5198 | |
| SRP133303 | MBD1 | 4152 | RNAseq | -0.1266 | 0.3965 | |
| SRP159526 | MBD1 | 4152 | RNAseq | 0.0298 | 0.9231 | |
| SRP193095 | MBD1 | 4152 | RNAseq | 0.2061 | 0.0283 | |
| SRP219564 | MBD1 | 4152 | RNAseq | -0.1952 | 0.4402 | |
| TCGA | MBD1 | 4152 | RNAseq | -0.0486 | 0.3353 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MBD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MBD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MBD1 | 4152 | 1 | 9 | 20 | |
| GSE20123 | MBD1 | 4152 | 1 | 9 | 20 | |
| GSE43470 | MBD1 | 4152 | 0 | 4 | 39 | |
| GSE46452 | MBD1 | 4152 | 1 | 26 | 32 | |
| GSE47630 | MBD1 | 4152 | 5 | 20 | 15 | |
| GSE54993 | MBD1 | 4152 | 9 | 0 | 61 | |
| GSE54994 | MBD1 | 4152 | 1 | 17 | 35 | |
| GSE60625 | MBD1 | 4152 | 0 | 4 | 7 | |
| GSE74703 | MBD1 | 4152 | 0 | 4 | 32 | |
| GSE74704 | MBD1 | 4152 | 1 | 6 | 13 | |
| TCGA | MBD1 | 4152 | 9 | 44 | 43 |
Total number of gains: 28; Total number of losses: 143; Total Number of normals: 317.
Somatic mutations of MBD1:
Generating mutation plots.
Highly correlated genes for MBD1:
Showing top 20/382 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MBD1 | TBC1D4 | 0.809738 | 3 | 0 | 3 |
| MBD1 | C9orf85 | 0.781581 | 3 | 0 | 3 |
| MBD1 | RSPRY1 | 0.770024 | 3 | 0 | 3 |
| MBD1 | SPPL3 | 0.768972 | 3 | 0 | 3 |
| MBD1 | TTC23 | 0.752932 | 3 | 0 | 3 |
| MBD1 | ZNF426 | 0.733191 | 3 | 0 | 3 |
| MBD1 | WHAMM | 0.731677 | 3 | 0 | 3 |
| MBD1 | CMC1 | 0.729088 | 4 | 0 | 3 |
| MBD1 | MRPS18B | 0.72541 | 3 | 0 | 3 |
| MBD1 | COG6 | 0.714673 | 4 | 0 | 4 |
| MBD1 | PIGV | 0.712478 | 3 | 0 | 3 |
| MBD1 | GPBP1 | 0.708685 | 3 | 0 | 3 |
| MBD1 | ZFC3H1 | 0.708622 | 4 | 0 | 4 |
| MBD1 | EXOC2 | 0.706158 | 3 | 0 | 3 |
| MBD1 | TSPAN3 | 0.703266 | 3 | 0 | 3 |
| MBD1 | MRPL39 | 0.701207 | 4 | 0 | 3 |
| MBD1 | IFRD2 | 0.700131 | 3 | 0 | 3 |
| MBD1 | THUMPD3 | 0.699032 | 3 | 0 | 3 |
| MBD1 | HYOU1 | 0.696193 | 3 | 0 | 3 |
| MBD1 | TMEM161B | 0.694597 | 3 | 0 | 3 |
For details and further investigation, click here
