| Full name: integrator complex subunit 6 | Alias Symbol: DICE1|HDB|Notchl2|DBI-1|DDX26A|INT6 | ||
| Type: protein-coding gene | Cytoband: 13q14.3 | ||
| Entrez ID: 26512 | HGNC ID: HGNC:14879 | Ensembl Gene: ENSG00000102786 | OMIM ID: 604331 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of INTS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INTS6 | 26512 | 218819_at | 0.0362 | 0.9703 | |
| GSE20347 | INTS6 | 26512 | 218819_at | -0.5782 | 0.0002 | |
| GSE23400 | INTS6 | 26512 | 218819_at | -0.0390 | 0.6984 | |
| GSE26886 | INTS6 | 26512 | 218819_at | -0.7649 | 0.0050 | |
| GSE29001 | INTS6 | 26512 | 218819_at | -0.2812 | 0.3791 | |
| GSE38129 | INTS6 | 26512 | 218819_at | -0.4791 | 0.0356 | |
| GSE45670 | INTS6 | 26512 | 218819_at | 0.1326 | 0.4604 | |
| GSE53622 | INTS6 | 26512 | 77493 | -0.0876 | 0.2016 | |
| GSE53624 | INTS6 | 26512 | 77493 | -0.1958 | 0.0009 | |
| GSE63941 | INTS6 | 26512 | 218819_at | 0.1442 | 0.7714 | |
| GSE77861 | INTS6 | 26512 | 218819_at | -0.0265 | 0.9569 | |
| GSE97050 | INTS6 | 26512 | A_24_P167614 | -0.1388 | 0.5564 | |
| SRP007169 | INTS6 | 26512 | RNAseq | -0.4395 | 0.2432 | |
| SRP008496 | INTS6 | 26512 | RNAseq | -0.2178 | 0.3966 | |
| SRP064894 | INTS6 | 26512 | RNAseq | -0.1404 | 0.4628 | |
| SRP133303 | INTS6 | 26512 | RNAseq | 0.0903 | 0.6578 | |
| SRP159526 | INTS6 | 26512 | RNAseq | -0.5854 | 0.1008 | |
| SRP193095 | INTS6 | 26512 | RNAseq | -0.4415 | 0.0001 | |
| SRP219564 | INTS6 | 26512 | RNAseq | -0.7225 | 0.0155 | |
| TCGA | INTS6 | 26512 | RNAseq | -0.1281 | 0.0091 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by INTS6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INTS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INTS6 | 26512 | 1 | 12 | 17 | |
| GSE20123 | INTS6 | 26512 | 1 | 11 | 18 | |
| GSE43470 | INTS6 | 26512 | 3 | 12 | 28 | |
| GSE46452 | INTS6 | 26512 | 0 | 32 | 27 | |
| GSE47630 | INTS6 | 26512 | 2 | 27 | 11 | |
| GSE54993 | INTS6 | 26512 | 12 | 2 | 56 | |
| GSE54994 | INTS6 | 26512 | 1 | 15 | 37 | |
| GSE60625 | INTS6 | 26512 | 0 | 3 | 8 | |
| GSE74703 | INTS6 | 26512 | 3 | 10 | 23 | |
| GSE74704 | INTS6 | 26512 | 0 | 8 | 12 | |
| TCGA | INTS6 | 26512 | 9 | 37 | 50 |
Total number of gains: 32; Total number of losses: 169; Total Number of normals: 287.
Somatic mutations of INTS6:
Generating mutation plots.
Highly correlated genes for INTS6:
Showing top 20/367 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INTS6 | MEIS2 | 0.764974 | 3 | 0 | 3 |
| INTS6 | GGA3 | 0.75623 | 3 | 0 | 3 |
| INTS6 | OPHN1 | 0.755337 | 3 | 0 | 3 |
| INTS6 | SRSF11 | 0.754089 | 3 | 0 | 3 |
| INTS6 | SIDT2 | 0.749308 | 3 | 0 | 3 |
| INTS6 | MRPS22 | 0.747303 | 3 | 0 | 3 |
| INTS6 | SAMD4B | 0.740602 | 3 | 0 | 3 |
| INTS6 | ZNF432 | 0.739069 | 3 | 0 | 3 |
| INTS6 | ZKSCAN1 | 0.725984 | 3 | 0 | 3 |
| INTS6 | FNBP4 | 0.71725 | 3 | 0 | 3 |
| INTS6 | PIGM | 0.714961 | 3 | 0 | 3 |
| INTS6 | VGLL4 | 0.712758 | 3 | 0 | 3 |
| INTS6 | SP1 | 0.712411 | 3 | 0 | 3 |
| INTS6 | KLHL3 | 0.708505 | 3 | 0 | 3 |
| INTS6 | EIF5 | 0.707776 | 3 | 0 | 3 |
| INTS6 | NDUFA3 | 0.702724 | 3 | 0 | 3 |
| INTS6 | SLC28A3 | 0.702331 | 3 | 0 | 3 |
| INTS6 | ADHFE1 | 0.701484 | 3 | 0 | 3 |
| INTS6 | IER3IP1 | 0.696195 | 3 | 0 | 3 |
| INTS6 | AZI2 | 0.69599 | 5 | 0 | 5 |
For details and further investigation, click here
