| Full name: protein phosphatase 6 catalytic subunit | Alias Symbol: PP6 | ||
| Type: protein-coding gene | Cytoband: 9q33.3 | ||
| Entrez ID: 5537 | HGNC ID: HGNC:9323 | Ensembl Gene: ENSG00000119414 | OMIM ID: 612725 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PPP6C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP6C | 5537 | 203529_at | -0.2064 | 0.4851 | |
| GSE20347 | PPP6C | 5537 | 203529_at | -0.5533 | 0.0001 | |
| GSE23400 | PPP6C | 5537 | 203529_at | -0.1065 | 0.0850 | |
| GSE26886 | PPP6C | 5537 | 203529_at | -0.5599 | 0.0013 | |
| GSE29001 | PPP6C | 5537 | 203529_at | -0.3759 | 0.0599 | |
| GSE38129 | PPP6C | 5537 | 203529_at | -0.4596 | 0.0003 | |
| GSE45670 | PPP6C | 5537 | 203529_at | -0.1418 | 0.2912 | |
| GSE53622 | PPP6C | 5537 | 5200 | -0.4955 | 0.0000 | |
| GSE53624 | PPP6C | 5537 | 5200 | -0.3039 | 0.0000 | |
| GSE63941 | PPP6C | 5537 | 203529_at | 0.6805 | 0.0568 | |
| GSE77861 | PPP6C | 5537 | 203529_at | -0.2620 | 0.2135 | |
| GSE97050 | PPP6C | 5537 | A_23_P355385 | -0.1880 | 0.4608 | |
| SRP007169 | PPP6C | 5537 | RNAseq | -0.8434 | 0.0390 | |
| SRP008496 | PPP6C | 5537 | RNAseq | -0.6812 | 0.0012 | |
| SRP064894 | PPP6C | 5537 | RNAseq | -0.3393 | 0.0072 | |
| SRP133303 | PPP6C | 5537 | RNAseq | -0.1338 | 0.3237 | |
| SRP159526 | PPP6C | 5537 | RNAseq | -0.4068 | 0.0261 | |
| SRP193095 | PPP6C | 5537 | RNAseq | -0.4198 | 0.0003 | |
| SRP219564 | PPP6C | 5537 | RNAseq | -0.5859 | 0.0073 | |
| TCGA | PPP6C | 5537 | RNAseq | -0.0305 | 0.4964 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP6C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP6C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP6C | 5537 | 4 | 8 | 18 | |
| GSE20123 | PPP6C | 5537 | 4 | 8 | 18 | |
| GSE43470 | PPP6C | 5537 | 5 | 5 | 33 | |
| GSE46452 | PPP6C | 5537 | 6 | 13 | 40 | |
| GSE47630 | PPP6C | 5537 | 3 | 16 | 21 | |
| GSE54993 | PPP6C | 5537 | 3 | 3 | 64 | |
| GSE54994 | PPP6C | 5537 | 12 | 8 | 33 | |
| GSE60625 | PPP6C | 5537 | 0 | 0 | 11 | |
| GSE74703 | PPP6C | 5537 | 5 | 3 | 28 | |
| GSE74704 | PPP6C | 5537 | 2 | 6 | 12 | |
| TCGA | PPP6C | 5537 | 27 | 25 | 44 |
Total number of gains: 71; Total number of losses: 95; Total Number of normals: 322.
Somatic mutations of PPP6C:
Generating mutation plots.
Highly correlated genes for PPP6C:
Showing top 20/1164 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP6C | ALKBH7 | 0.788679 | 3 | 0 | 3 |
| PPP6C | MRRF | 0.760418 | 4 | 0 | 4 |
| PPP6C | GTF3C6 | 0.751651 | 3 | 0 | 3 |
| PPP6C | ZNRF1 | 0.711739 | 4 | 0 | 4 |
| PPP6C | THUMPD3 | 0.702523 | 3 | 0 | 3 |
| PPP6C | UBE2NL | 0.699672 | 3 | 0 | 3 |
| PPP6C | ARPC5L | 0.69926 | 12 | 0 | 10 |
| PPP6C | UQCRFS1 | 0.69452 | 3 | 0 | 3 |
| PPP6C | ACO1 | 0.693236 | 3 | 0 | 3 |
| PPP6C | EGLN1 | 0.693142 | 3 | 0 | 3 |
| PPP6C | CCNYL1 | 0.692136 | 5 | 0 | 4 |
| PPP6C | VRK3 | 0.690371 | 3 | 0 | 3 |
| PPP6C | ANO8 | 0.68913 | 5 | 0 | 4 |
| PPP6C | P2RY13 | 0.68846 | 3 | 0 | 3 |
| PPP6C | MOCS2 | 0.68665 | 3 | 0 | 3 |
| PPP6C | UBE2R2 | 0.684336 | 6 | 0 | 5 |
| PPP6C | TINF2 | 0.682616 | 3 | 0 | 3 |
| PPP6C | PITHD1 | 0.681984 | 5 | 0 | 5 |
| PPP6C | GAPVD1 | 0.679425 | 12 | 0 | 12 |
| PPP6C | ACAA1 | 0.675297 | 9 | 0 | 8 |
For details and further investigation, click here
