| Full name: phosphoenolpyruvate carboxykinase 2, mitochondrial | Alias Symbol: PEPCK|PEPCK2 | ||
| Type: protein-coding gene | Cytoband: 14q11.2-q12 | ||
| Entrez ID: 5106 | HGNC ID: HGNC:8725 | Ensembl Gene: ENSG00000100889 | OMIM ID: 614095 |
| Drug and gene relationship at DGIdb | |||
PCK2 involved pathways:
Expression of PCK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCK2 | 5106 | 202847_at | 0.1581 | 0.8634 | |
| GSE20347 | PCK2 | 5106 | 202847_at | 0.6469 | 0.0058 | |
| GSE23400 | PCK2 | 5106 | 202847_at | 0.2428 | 0.0038 | |
| GSE26886 | PCK2 | 5106 | 202847_at | 0.3662 | 0.0229 | |
| GSE29001 | PCK2 | 5106 | 202847_at | 0.5908 | 0.0423 | |
| GSE38129 | PCK2 | 5106 | 202847_at | 0.6141 | 0.0022 | |
| GSE45670 | PCK2 | 5106 | 202847_at | 0.5744 | 0.0365 | |
| GSE53622 | PCK2 | 5106 | 63963 | 0.5718 | 0.0000 | |
| GSE53624 | PCK2 | 5106 | 63963 | 0.6646 | 0.0000 | |
| GSE63941 | PCK2 | 5106 | 202847_at | 0.4329 | 0.6852 | |
| GSE77861 | PCK2 | 5106 | 202847_at | 0.4426 | 0.0229 | |
| GSE97050 | PCK2 | 5106 | A_23_P128817 | 0.5662 | 0.1546 | |
| SRP007169 | PCK2 | 5106 | RNAseq | 1.0462 | 0.0145 | |
| SRP008496 | PCK2 | 5106 | RNAseq | 0.9077 | 0.0213 | |
| SRP064894 | PCK2 | 5106 | RNAseq | 0.7086 | 0.0176 | |
| SRP133303 | PCK2 | 5106 | RNAseq | 0.5426 | 0.1526 | |
| SRP159526 | PCK2 | 5106 | RNAseq | 0.3253 | 0.3184 | |
| SRP193095 | PCK2 | 5106 | RNAseq | -0.1834 | 0.4787 | |
| SRP219564 | PCK2 | 5106 | RNAseq | 0.5806 | 0.1770 | |
| TCGA | PCK2 | 5106 | RNAseq | 0.1391 | 0.0856 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PCK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCK2 | 5106 | 8 | 3 | 19 | |
| GSE20123 | PCK2 | 5106 | 8 | 3 | 19 | |
| GSE43470 | PCK2 | 5106 | 8 | 2 | 33 | |
| GSE46452 | PCK2 | 5106 | 16 | 2 | 41 | |
| GSE47630 | PCK2 | 5106 | 11 | 10 | 19 | |
| GSE54993 | PCK2 | 5106 | 3 | 11 | 56 | |
| GSE54994 | PCK2 | 5106 | 18 | 5 | 30 | |
| GSE60625 | PCK2 | 5106 | 0 | 2 | 9 | |
| GSE74703 | PCK2 | 5106 | 7 | 2 | 27 | |
| GSE74704 | PCK2 | 5106 | 3 | 2 | 15 | |
| TCGA | PCK2 | 5106 | 27 | 13 | 56 |
Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.
Somatic mutations of PCK2:
Generating mutation plots.
Highly correlated genes for PCK2:
Showing top 20/557 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCK2 | PLEKHG1 | 0.725907 | 3 | 0 | 3 |
| PCK2 | DNPEP | 0.72303 | 3 | 0 | 3 |
| PCK2 | TTC39C | 0.71683 | 3 | 0 | 3 |
| PCK2 | MRRF | 0.703984 | 3 | 0 | 3 |
| PCK2 | ANKRD50 | 0.695542 | 3 | 0 | 3 |
| PCK2 | MRPL37 | 0.693282 | 3 | 0 | 3 |
| PCK2 | HAS3 | 0.682531 | 3 | 0 | 3 |
| PCK2 | UCP2 | 0.679346 | 4 | 0 | 3 |
| PCK2 | KIAA1257 | 0.676792 | 3 | 0 | 3 |
| PCK2 | SASS6 | 0.674675 | 3 | 0 | 3 |
| PCK2 | MDN1 | 0.671848 | 4 | 0 | 3 |
| PCK2 | MED15 | 0.671557 | 3 | 0 | 3 |
| PCK2 | COPS8 | 0.671206 | 3 | 0 | 3 |
| PCK2 | COL17A1 | 0.666415 | 3 | 0 | 3 |
| PCK2 | CWC22 | 0.663542 | 3 | 0 | 3 |
| PCK2 | MRPS23 | 0.662212 | 5 | 0 | 5 |
| PCK2 | ID1 | 0.661326 | 3 | 0 | 3 |
| PCK2 | UBQLN4 | 0.657393 | 3 | 0 | 3 |
| PCK2 | NIPA2 | 0.655219 | 5 | 0 | 4 |
| PCK2 | NUS1 | 0.647137 | 4 | 0 | 3 |
For details and further investigation, click here
