| Full name: low density lipoprotein receptor | Alias Symbol: LDLCQ2 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 3949 | HGNC ID: HGNC:6547 | Ensembl Gene: ENSG00000130164 | OMIM ID: 606945 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LDLR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LDLR | 3949 | 202068_s_at | -0.0383 | 0.9797 | |
| GSE20347 | LDLR | 3949 | 202068_s_at | -0.2743 | 0.3853 | |
| GSE23400 | LDLR | 3949 | 202068_s_at | -0.1678 | 0.2571 | |
| GSE26886 | LDLR | 3949 | 202068_s_at | 0.1822 | 0.7605 | |
| GSE29001 | LDLR | 3949 | 202068_s_at | -0.1419 | 0.8166 | |
| GSE38129 | LDLR | 3949 | 202068_s_at | 0.0587 | 0.8363 | |
| GSE45670 | LDLR | 3949 | 202068_s_at | 0.0545 | 0.8962 | |
| GSE53622 | LDLR | 3949 | 60028 | -0.4881 | 0.0004 | |
| GSE53624 | LDLR | 3949 | 60028 | -0.2010 | 0.0708 | |
| GSE63941 | LDLR | 3949 | 202068_s_at | -1.0471 | 0.1680 | |
| GSE77861 | LDLR | 3949 | 202068_s_at | 0.5843 | 0.0132 | |
| GSE97050 | LDLR | 3949 | A_24_P117029 | -0.1990 | 0.5091 | |
| SRP007169 | LDLR | 3949 | RNAseq | 0.4759 | 0.2642 | |
| SRP008496 | LDLR | 3949 | RNAseq | -0.0783 | 0.8189 | |
| SRP064894 | LDLR | 3949 | RNAseq | -1.1527 | 0.0023 | |
| SRP133303 | LDLR | 3949 | RNAseq | -0.3244 | 0.3292 | |
| SRP159526 | LDLR | 3949 | RNAseq | -0.4846 | 0.3154 | |
| SRP193095 | LDLR | 3949 | RNAseq | 0.1528 | 0.4787 | |
| SRP219564 | LDLR | 3949 | RNAseq | -0.2960 | 0.6162 | |
| TCGA | LDLR | 3949 | RNAseq | -0.0508 | 0.4477 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by LDLR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LDLR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LDLR | 3949 | 4 | 2 | 24 | |
| GSE20123 | LDLR | 3949 | 3 | 1 | 26 | |
| GSE43470 | LDLR | 3949 | 2 | 6 | 35 | |
| GSE46452 | LDLR | 3949 | 47 | 1 | 11 | |
| GSE47630 | LDLR | 3949 | 4 | 7 | 29 | |
| GSE54993 | LDLR | 3949 | 16 | 3 | 51 | |
| GSE54994 | LDLR | 3949 | 6 | 13 | 34 | |
| GSE60625 | LDLR | 3949 | 9 | 0 | 2 | |
| GSE74703 | LDLR | 3949 | 2 | 4 | 30 | |
| GSE74704 | LDLR | 3949 | 0 | 1 | 19 | |
| TCGA | LDLR | 3949 | 16 | 13 | 67 |
Total number of gains: 109; Total number of losses: 51; Total Number of normals: 328.
Somatic mutations of LDLR:
Generating mutation plots.
Highly correlated genes for LDLR:
Showing top 20/94 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LDLR | CLASP1 | 0.801059 | 3 | 0 | 3 |
| LDLR | RILPL1 | 0.740058 | 3 | 0 | 3 |
| LDLR | SLC25A13 | 0.727727 | 3 | 0 | 3 |
| LDLR | FEZ2 | 0.724969 | 3 | 0 | 3 |
| LDLR | TES | 0.720686 | 3 | 0 | 3 |
| LDLR | ADAM23 | 0.717625 | 3 | 0 | 3 |
| LDLR | GLS | 0.712479 | 3 | 0 | 3 |
| LDLR | HNRNPU | 0.709973 | 3 | 0 | 3 |
| LDLR | UTP20 | 0.701877 | 3 | 0 | 3 |
| LDLR | EIF5A2 | 0.69386 | 3 | 0 | 3 |
| LDLR | MACF1 | 0.693751 | 3 | 0 | 3 |
| LDLR | C1D | 0.691475 | 3 | 0 | 3 |
| LDLR | E2F3 | 0.689488 | 3 | 0 | 3 |
| LDLR | ZBTB2 | 0.683909 | 3 | 0 | 3 |
| LDLR | HNRNPL | 0.682796 | 3 | 0 | 3 |
| LDLR | MSL1 | 0.681594 | 3 | 0 | 3 |
| LDLR | KLF11 | 0.681137 | 3 | 0 | 3 |
| LDLR | SLC4A2 | 0.680934 | 3 | 0 | 3 |
| LDLR | CPT1A | 0.676141 | 3 | 0 | 3 |
| LDLR | SHCBP1 | 0.669697 | 3 | 0 | 3 |
For details and further investigation, click here
