THOC6

 

Full name: THO complex 6 Alias Symbol: MGC2655|fSAP35
Type: protein-coding gene Cytoband: 16p13.3
Entrez ID: 79228 HGNC ID: HGNC:28369 Ensembl Gene: ENSG00000131652 OMIM ID: 615403
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of THOC6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 THOC6 79228 218848_at 0.6626 0.1438
GSE20347 THOC6 79228 218848_at 0.5682 0.0005
GSE23400 THOC6 79228 218848_at 0.6246 0.0000
GSE26886 THOC6 79228 218848_at -0.2264 0.3052
GSE29001 THOC6 79228 218848_at 0.6388 0.0390
GSE38129 THOC6 79228 218848_at 0.7363 0.0001
GSE45670 THOC6 79228 218848_at 0.6293 0.0001
GSE53622 THOC6 79228 51588 0.9186 0.0000
GSE53624 THOC6 79228 51588 1.0665 0.0000
GSE63941 THOC6 79228 218848_at 1.0741 0.0357
GSE77861 THOC6 79228 218848_at 0.2426 0.1398
GSE97050 THOC6 79228 A_23_P37949 0.4307 0.2983
SRP007169 THOC6 79228 RNAseq 1.5982 0.0023
SRP008496 THOC6 79228 RNAseq 1.4994 0.0000
SRP064894 THOC6 79228 RNAseq 0.5485 0.0153
SRP133303 THOC6 79228 RNAseq 0.3521 0.0537
SRP159526 THOC6 79228 RNAseq 0.4600 0.0351
SRP193095 THOC6 79228 RNAseq 0.2565 0.0188
SRP219564 THOC6 79228 RNAseq 0.5893 0.1599
TCGA THOC6 79228 RNAseq 0.5055 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by THOC6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of THOC6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 THOC6 79228 5 5 20
GSE20123 THOC6 79228 5 4 21
GSE43470 THOC6 79228 3 8 32
GSE46452 THOC6 79228 38 1 20
GSE47630 THOC6 79228 13 6 21
GSE54993 THOC6 79228 3 5 62
GSE54994 THOC6 79228 5 9 39
GSE60625 THOC6 79228 4 0 7
GSE74703 THOC6 79228 3 6 27
GSE74704 THOC6 79228 3 2 15
TCGA THOC6 79228 19 13 64

Total number of gains: 101; Total number of losses: 59; Total Number of normals: 328.  

 

Somatic mutations of THOC6:

 

Generating mutation plots.

 

Highly correlated genes for THOC6:

 

Showing top 20/1829 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
THOC6ABCB60.784486303
THOC6MICALCL0.773928303
THOC6WDR540.772954606
THOC6CLSPN0.77192606
THOC6PYCR20.762432303
THOC6SLC35B20.762349303
THOC6NLN0.7608303
THOC6PDIA50.749553303
THOC6RNF260.746809404
THOC6MAP4K20.742108606
THOC6ZDHHC160.741477505
THOC6BOLA30.737867606
THOC6DNAJC190.735525303
THOC6NOP560.73535303
THOC6UBE2C0.73240411011
THOC6TUBA1B0.731125908
THOC6PSMG30.730122606
THOC6SNAP470.727512303
THOC6MRPS50.724898303
THOC6EBNA1BP20.724603303

For details and further investigation, click here