ACTG2

 

Full name: actin gamma 2, smooth muscle Alias Symbol: ACTSG
Type: protein-coding gene Cytoband: 2p13.1
Entrez ID: 72 HGNC ID: HGNC:145 Ensembl Gene: ENSG00000163017 OMIM ID: 102545
Drug and gene relationship at DGIdb

 

ACTG2 involved pathways:

KEGG pathway Description View
hsa04270Vascular smooth muscle contraction

 

Expression of ACTG2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ACTG2 72 202274_at -2.5662 0.1802
GSE20347 ACTG2 72 202274_at -1.4766 0.0221
GSE23400 ACTG2 72 202274_at -1.3173 0.0000
GSE26886 ACTG2 72 202274_at 1.2574 0.1283
GSE29001 ACTG2 72 202274_at -1.4896 0.1859
GSE38129 ACTG2 72 202274_at -1.5531 0.0183
GSE45670 ACTG2 72 202274_at -4.9940 0.0000
GSE53622 ACTG2 72 60499 -1.6921 0.0000
GSE53624 ACTG2 72 60499 -1.2986 0.0000
GSE63941 ACTG2 72 202274_at -5.4790 0.0001
GSE77861 ACTG2 72 202274_at 0.5753 0.3377
GSE97050 ACTG2 72 A_23_P39955 -1.4793 0.0682
SRP007169 ACTG2 72 RNAseq 3.1670 0.0002
SRP008496 ACTG2 72 RNAseq 5.2078 0.0000
SRP064894 ACTG2 72 RNAseq -1.3947 0.0034
SRP133303 ACTG2 72 RNAseq -0.8115 0.4098
SRP219564 ACTG2 72 RNAseq -1.6948 0.2029
TCGA ACTG2 72 RNAseq -0.7691 0.0002

Upregulated datasets: 2; Downregulated datasets: 8.  

 

Survival by ACTG2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ACTG2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ACTG2 72 10 1 19
GSE20123 ACTG2 72 10 1 19
GSE43470 ACTG2 72 4 0 39
GSE46452 ACTG2 72 2 3 54
GSE47630 ACTG2 72 7 0 33
GSE54993 ACTG2 72 0 6 64
GSE54994 ACTG2 72 10 0 43
GSE60625 ACTG2 72 0 3 8
GSE74703 ACTG2 72 4 0 32
GSE74704 ACTG2 72 8 0 12
TCGA ACTG2 72 38 2 56

Total number of gains: 93; Total number of losses: 16; Total Number of normals: 379.  

 

Somatic mutations of ACTG2:

 

Generating mutation plots.

 

Highly correlated genes for ACTG2:

 

Showing top 20/1077 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ACTG2CNN10.90946511011
ACTG2ACTA20.89554313013
ACTG2MYH110.88723512012
ACTG2ACTBL20.879879303
ACTG2LMOD10.87398313013
ACTG2TAGLN0.86889512012
ACTG2MRVI10.867968808
ACTG2MYOCD0.859806707
ACTG2PLN0.84960213013
ACTG2NEXN0.847914909
ACTG2SYNM0.83844512012
ACTG2AFF30.837596303
ACTG2MSRB30.836645707
ACTG2TPM20.83569313013
ACTG2LINC012790.827737404
ACTG2MYLK0.8228713013
ACTG2PRUNE20.82215213013
ACTG2DES0.82068113012
ACTG2AOC30.82044813012
ACTG2PPP1R12B0.81563212012

For details and further investigation, click here