| Full name: microtubule crosslinking factor 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18p11.22 | ||
| Entrez ID: 23255 | HGNC ID: HGNC:29121 | Ensembl Gene: ENSG00000168502 | OMIM ID: 615766 |
| Drug and gene relationship at DGIdb | |||
Expression of MTCL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTCL1 | 23255 | 213358_at | 0.7871 | 0.5095 | |
| GSE20347 | MTCL1 | 23255 | 213358_at | 1.2576 | 0.0000 | |
| GSE23400 | MTCL1 | 23255 | 213358_at | 0.6263 | 0.0000 | |
| GSE26886 | MTCL1 | 23255 | 213358_at | 1.9084 | 0.0000 | |
| GSE29001 | MTCL1 | 23255 | 213358_at | 1.2246 | 0.0050 | |
| GSE38129 | MTCL1 | 23255 | 213358_at | 0.9061 | 0.0013 | |
| GSE45670 | MTCL1 | 23255 | 213358_at | 1.0175 | 0.0023 | |
| GSE53622 | MTCL1 | 23255 | 46864 | 0.7349 | 0.0000 | |
| GSE53624 | MTCL1 | 23255 | 31188 | 0.8974 | 0.0000 | |
| GSE63941 | MTCL1 | 23255 | 213358_at | -1.0210 | 0.2951 | |
| GSE77861 | MTCL1 | 23255 | 213358_at | 1.2871 | 0.0575 | |
| SRP007169 | MTCL1 | 23255 | RNAseq | 3.2216 | 0.0000 | |
| SRP008496 | MTCL1 | 23255 | RNAseq | 3.2236 | 0.0000 | |
| SRP064894 | MTCL1 | 23255 | RNAseq | 0.6275 | 0.0379 | |
| SRP133303 | MTCL1 | 23255 | RNAseq | 0.9285 | 0.0025 | |
| SRP159526 | MTCL1 | 23255 | RNAseq | 1.2663 | 0.0214 | |
| SRP193095 | MTCL1 | 23255 | RNAseq | 1.3564 | 0.0000 | |
| SRP219564 | MTCL1 | 23255 | RNAseq | 0.3004 | 0.6150 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by MTCL1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of MTCL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTCL1 | 23255 | 6 | 3 | 21 | |
| GSE20123 | MTCL1 | 23255 | 6 | 3 | 21 | |
| GSE43470 | MTCL1 | 23255 | 4 | 5 | 34 | |
| GSE46452 | MTCL1 | 23255 | 3 | 21 | 35 | |
| GSE47630 | MTCL1 | 23255 | 7 | 17 | 16 | |
| GSE54993 | MTCL1 | 23255 | 6 | 3 | 61 | |
| GSE54994 | MTCL1 | 23255 | 9 | 8 | 36 | |
| GSE60625 | MTCL1 | 23255 | 0 | 4 | 7 | |
| GSE74703 | MTCL1 | 23255 | 3 | 3 | 30 | |
| GSE74704 | MTCL1 | 23255 | 4 | 2 | 14 |
Total number of gains: 48; Total number of losses: 69; Total Number of normals: 275.
Somatic mutations of MTCL1:
Generating mutation plots.
Highly correlated genes for MTCL1:
Showing top 20/767 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTCL1 | DARS2 | 0.733661 | 3 | 0 | 3 |
| MTCL1 | CD276 | 0.715416 | 3 | 0 | 3 |
| MTCL1 | SCYL1 | 0.707447 | 3 | 0 | 3 |
| MTCL1 | SIX5 | 0.699954 | 3 | 0 | 3 |
| MTCL1 | AGAP2-AS1 | 0.699848 | 3 | 0 | 3 |
| MTCL1 | SKA3 | 0.699409 | 3 | 0 | 3 |
| MTCL1 | TNFAIP8L1 | 0.692691 | 3 | 0 | 3 |
| MTCL1 | TMEM158 | 0.689072 | 7 | 0 | 6 |
| MTCL1 | GALNT18 | 0.68183 | 6 | 0 | 6 |
| MTCL1 | C1orf131 | 0.678368 | 4 | 0 | 4 |
| MTCL1 | ITPK1-AS1 | 0.675886 | 3 | 0 | 3 |
| MTCL1 | FMNL2 | 0.672624 | 6 | 0 | 5 |
| MTCL1 | STIM2 | 0.669629 | 4 | 0 | 3 |
| MTCL1 | BRAT1 | 0.66591 | 6 | 0 | 5 |
| MTCL1 | KRTCAP2 | 0.665666 | 4 | 0 | 4 |
| MTCL1 | POU6F2-AS2 | 0.65991 | 4 | 0 | 4 |
| MTCL1 | HOMER1 | 0.658844 | 4 | 0 | 4 |
| MTCL1 | SLC6A6 | 0.653748 | 4 | 0 | 3 |
| MTCL1 | EPPK1 | 0.653635 | 6 | 0 | 6 |
| MTCL1 | HOXA10 | 0.653576 | 5 | 0 | 5 |
For details and further investigation, click here
