Full name: spindle and kinetochore associated complex subunit 3	Alias Symbol: MGC4832|RAMA1
Type: protein-coding gene	Cytoband: 13q12.11
Entrez ID: 221150	HGNC ID: HGNC:20262	Ensembl Gene: ENSG00000165480	OMIM ID:
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 139/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of SKA3:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	SKA3	221150	227165_at	0.7715	0.2423	Show
GSE26886	SKA3	221150	227165_at	-0.0175	0.9363	Show
GSE45670	SKA3	221150	227165_at	0.8439	0.0000	Show
GSE53622	SKA3	221150	66820	0.7636	0.0000	Show
GSE53624	SKA3	221150	66820	1.3749	0.0000	Show
GSE63941	SKA3	221150	227165_at	1.7420	0.0044	Show
GSE77861	SKA3	221150	227165_at	0.2166	0.1635	Show
GSE97050	SKA3	221150	A_33_P3216008	0.5041	0.2193	Show
SRP007169	SKA3	221150	RNAseq	0.5049	0.2980	Show
SRP064894	SKA3	221150	RNAseq	1.3487	0.0001	Show
SRP133303	SKA3	221150	RNAseq	1.2755	0.0000	Show
SRP159526	SKA3	221150	RNAseq	0.8382	0.0009	Show
SRP193095	SKA3	221150	RNAseq	0.4309	0.0188	Show
SRP219564	SKA3	221150	RNAseq	1.1400	0.1325	Show
TCGA	SKA3	221150	RNAseq	1.2959	0.0000	Show

Upregulated datasets: 5; Downregulated datasets: 0.  Download Data

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Survival by SKA3 expression:

 

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Copy number change of SKA3:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	SKA3	221150	1	14	15	Show
GSE20123	SKA3	221150	1	13	16	Show
GSE43470	SKA3	221150	2	13	28	Show
GSE46452	SKA3	221150	0	33	26	Show
GSE47630	SKA3	221150	3	26	11	Show
GSE54993	SKA3	221150	11	2	57	Show
GSE54994	SKA3	221150	1	13	39	Show
GSE60625	SKA3	221150	0	3	8	Show
GSE74703	SKA3	221150	2	10	24	Show
GSE74704	SKA3	221150	0	11	9	Show
TCGA	SKA3	221150	6	43	47	Show

Total number of gains: 27; Total number of losses: 181; Total Number of normals: 280.  Download Data

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Somatic mutations of SKA3:

 

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Highly correlated genes for SKA3:

 

Showing top 20/1506 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
SKA3	EXO1	0.821563	6	0	6
SKA3	CDT1	0.808914	7	0	7
SKA3	C1orf112	0.798033	5	0	5
SKA3	HJURP	0.797123	8	0	8
SKA3	CEP55	0.795432	8	0	8
SKA3	KIFC1	0.791372	7	0	7
SKA3	UBE2T	0.780404	7	0	7
SKA3	MELK	0.77643	8	0	8
SKA3	PRC1	0.77627	8	0	8
SKA3	NDC80	0.775796	7	0	7
SKA3	NEK2	0.774764	8	0	8
SKA3	CENPA	0.773623	7	0	7
SKA3	CENPW	0.77223	6	0	6
SKA3	KNSTRN	0.770122	6	0	6
SKA3	BIRC5	0.769792	8	0	8
SKA3	FANCI	0.767663	7	0	7
SKA3	NUSAP1	0.765487	8	0	8
SKA3	KIF2C	0.759708	7	0	7
SKA3	KIF11	0.7592	8	0	8
SKA3	DKC1	0.755585	3	0	3

For details and further investigation, click here