| Full name: mucin 1, cell surface associated | Alias Symbol: CD227|PEM|ADMCKD|ADMCKD1|MCKD|MCD | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 4582 | HGNC ID: HGNC:7508 | Ensembl Gene: ENSG00000185499 | OMIM ID: 158340 |
| Drug and gene relationship at DGIdb | |||
Expression of MUC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MUC1 | 4582 | 213693_s_at | -0.9555 | 0.3765 | |
| GSE20347 | MUC1 | 4582 | 213693_s_at | -1.4897 | 0.0004 | |
| GSE23400 | MUC1 | 4582 | 213693_s_at | -1.4167 | 0.0000 | |
| GSE26886 | MUC1 | 4582 | 213693_s_at | -2.3956 | 0.0000 | |
| GSE29001 | MUC1 | 4582 | 213693_s_at | -1.6469 | 0.0066 | |
| GSE38129 | MUC1 | 4582 | 213693_s_at | -1.3518 | 0.0001 | |
| GSE45670 | MUC1 | 4582 | 213693_s_at | -0.6860 | 0.0983 | |
| GSE53622 | MUC1 | 4582 | 76902 | -1.4460 | 0.0000 | |
| GSE53624 | MUC1 | 4582 | 76902 | -0.7414 | 0.0000 | |
| GSE63941 | MUC1 | 4582 | 213693_s_at | 0.5151 | 0.6816 | |
| GSE77861 | MUC1 | 4582 | 213693_s_at | -1.0909 | 0.0128 | |
| GSE97050 | MUC1 | 4582 | A_33_P3332215 | -0.0456 | 0.9692 | |
| SRP007169 | MUC1 | 4582 | RNAseq | -4.1027 | 0.0000 | |
| SRP008496 | MUC1 | 4582 | RNAseq | -4.5157 | 0.0000 | |
| SRP064894 | MUC1 | 4582 | RNAseq | -1.5942 | 0.0041 | |
| SRP133303 | MUC1 | 4582 | RNAseq | -2.3469 | 0.0000 | |
| SRP159526 | MUC1 | 4582 | RNAseq | -2.6834 | 0.0000 | |
| SRP193095 | MUC1 | 4582 | RNAseq | -1.4651 | 0.0037 | |
| SRP219564 | MUC1 | 4582 | RNAseq | 0.8523 | 0.3965 | |
| TCGA | MUC1 | 4582 | RNAseq | -0.8586 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by MUC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MUC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MUC1 | 4582 | 14 | 0 | 16 | |
| GSE20123 | MUC1 | 4582 | 13 | 0 | 17 | |
| GSE43470 | MUC1 | 4582 | 6 | 2 | 35 | |
| GSE46452 | MUC1 | 4582 | 2 | 1 | 56 | |
| GSE47630 | MUC1 | 4582 | 14 | 0 | 26 | |
| GSE54993 | MUC1 | 4582 | 0 | 4 | 66 | |
| GSE54994 | MUC1 | 4582 | 16 | 0 | 37 | |
| GSE60625 | MUC1 | 4582 | 0 | 0 | 11 | |
| GSE74703 | MUC1 | 4582 | 6 | 1 | 29 | |
| GSE74704 | MUC1 | 4582 | 6 | 0 | 14 | |
| TCGA | MUC1 | 4582 | 38 | 2 | 56 |
Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.
Somatic mutations of MUC1:
Generating mutation plots.
Highly correlated genes for MUC1:
Showing top 20/1340 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MUC1 | TRNP1 | 0.79003 | 6 | 0 | 6 |
| MUC1 | B3GNT6 | 0.762981 | 6 | 0 | 6 |
| MUC1 | ATP13A4 | 0.757721 | 7 | 0 | 7 |
| MUC1 | ARHGAP27 | 0.755489 | 7 | 0 | 7 |
| MUC1 | C1orf116 | 0.739853 | 11 | 0 | 11 |
| MUC1 | KLB | 0.738968 | 6 | 0 | 6 |
| MUC1 | TMEM234 | 0.734401 | 3 | 0 | 3 |
| MUC1 | RBM47 | 0.732181 | 12 | 0 | 11 |
| MUC1 | PSCA | 0.731078 | 9 | 0 | 9 |
| MUC1 | SLC44A3 | 0.730694 | 7 | 0 | 7 |
| MUC1 | C6orf132 | 0.729432 | 8 | 0 | 8 |
| MUC1 | ST6GALNAC1 | 0.728108 | 8 | 0 | 8 |
| MUC1 | FAM3B | 0.727685 | 6 | 0 | 6 |
| MUC1 | EPS8L1 | 0.727636 | 13 | 0 | 12 |
| MUC1 | EPS8L2 | 0.726961 | 11 | 0 | 10 |
| MUC1 | LIPH | 0.726554 | 8 | 0 | 7 |
| MUC1 | SASH1 | 0.7259 | 11 | 0 | 11 |
| MUC1 | RANBP9 | 0.725895 | 11 | 0 | 11 |
| MUC1 | RMND5B | 0.721682 | 10 | 0 | 10 |
| MUC1 | CXCL17 | 0.719937 | 9 | 0 | 8 |
For details and further investigation, click here
