| Full name: calpain 8 | Alias Symbol: nCL-2 | ||
| Type: protein-coding gene | Cytoband: 1q41 | ||
| Entrez ID: 388743 | HGNC ID: HGNC:1485 | Ensembl Gene: ENSG00000203697 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of CAPN8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAPN8 | 388743 | 229030_at | -0.0603 | 0.8470 | |
| GSE26886 | CAPN8 | 388743 | 229030_at | 0.0735 | 0.5701 | |
| GSE45670 | CAPN8 | 388743 | 229030_at | -0.0384 | 0.8410 | |
| GSE53622 | CAPN8 | 388743 | 17410 | -1.0401 | 0.0096 | |
| GSE53624 | CAPN8 | 388743 | 17410 | -1.5406 | 0.0000 | |
| GSE63941 | CAPN8 | 388743 | 229030_at | 0.5044 | 0.5798 | |
| GSE77861 | CAPN8 | 388743 | 229030_at | 0.0736 | 0.4951 | |
| SRP219564 | CAPN8 | 388743 | RNAseq | 0.0186 | 0.9862 | |
| TCGA | CAPN8 | 388743 | RNAseq | -3.8391 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CAPN8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAPN8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAPN8 | 388743 | 10 | 0 | 20 | |
| GSE20123 | CAPN8 | 388743 | 10 | 0 | 20 | |
| GSE43470 | CAPN8 | 388743 | 8 | 0 | 35 | |
| GSE46452 | CAPN8 | 388743 | 3 | 1 | 55 | |
| GSE47630 | CAPN8 | 388743 | 15 | 0 | 25 | |
| GSE54993 | CAPN8 | 388743 | 0 | 6 | 64 | |
| GSE54994 | CAPN8 | 388743 | 16 | 0 | 37 | |
| GSE60625 | CAPN8 | 388743 | 0 | 0 | 11 | |
| GSE74703 | CAPN8 | 388743 | 8 | 0 | 28 | |
| GSE74704 | CAPN8 | 388743 | 4 | 0 | 16 | |
| TCGA | CAPN8 | 388743 | 46 | 4 | 46 |
Total number of gains: 120; Total number of losses: 11; Total Number of normals: 357.
Somatic mutations of CAPN8:
Generating mutation plots.
Highly correlated genes for CAPN8:
Showing top 20/49 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAPN8 | TFF1 | 0.732006 | 5 | 0 | 4 |
| CAPN8 | MS4A8 | 0.698413 | 3 | 0 | 3 |
| CAPN8 | TFF2 | 0.690111 | 5 | 0 | 5 |
| CAPN8 | LINC00261 | 0.668374 | 3 | 0 | 3 |
| CAPN8 | KIAA1324 | 0.665171 | 5 | 0 | 5 |
| CAPN8 | CLSTN2 | 0.664427 | 3 | 0 | 3 |
| CAPN8 | NCALD | 0.656918 | 3 | 0 | 3 |
| CAPN8 | MUC5B | 0.643964 | 5 | 0 | 4 |
| CAPN8 | LAT2 | 0.63437 | 3 | 0 | 3 |
| CAPN8 | TESC | 0.632917 | 6 | 0 | 5 |
| CAPN8 | CAPN9 | 0.628456 | 6 | 0 | 4 |
| CAPN8 | AZGP1 | 0.622393 | 5 | 0 | 5 |
| CAPN8 | BPIFB1 | 0.621388 | 4 | 0 | 4 |
| CAPN8 | AGR3 | 0.620719 | 6 | 0 | 6 |
| CAPN8 | SLC44A4 | 0.6187 | 6 | 0 | 5 |
| CAPN8 | NFE2 | 0.617925 | 3 | 0 | 3 |
| CAPN8 | PIGR | 0.616853 | 3 | 0 | 3 |
| CAPN8 | TFF3 | 0.616258 | 6 | 0 | 5 |
| CAPN8 | GP2 | 0.615992 | 4 | 0 | 3 |
| CAPN8 | AGR2 | 0.608595 | 5 | 0 | 4 |
For details and further investigation, click here
