| Full name: phosphatase and actin regulator 1 | Alias Symbol: KIAA1733|dJ257A7.2 | ||
| Type: protein-coding gene | Cytoband: 6p24.1 | ||
| Entrez ID: 221692 | HGNC ID: HGNC:20990 | Ensembl Gene: ENSG00000112137 | OMIM ID: 608723 |
| Drug and gene relationship at DGIdb | |||
Expression of PHACTR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHACTR1 | 221692 | 226397_s_at | 0.0736 | 0.9394 | |
| GSE20347 | PHACTR1 | 221692 | 213638_at | -0.0931 | 0.1832 | |
| GSE23400 | PHACTR1 | 221692 | 213638_at | -0.0677 | 0.0174 | |
| GSE26886 | PHACTR1 | 221692 | 232045_at | -0.1044 | 0.3607 | |
| GSE29001 | PHACTR1 | 221692 | 213638_at | -0.0383 | 0.8255 | |
| GSE38129 | PHACTR1 | 221692 | 213638_at | -0.0947 | 0.2779 | |
| GSE45670 | PHACTR1 | 221692 | 232045_at | -0.2098 | 0.0259 | |
| GSE53622 | PHACTR1 | 221692 | 62738 | -0.5104 | 0.0003 | |
| GSE53624 | PHACTR1 | 221692 | 62738 | -0.4699 | 0.0000 | |
| GSE63941 | PHACTR1 | 221692 | 226397_s_at | 0.5963 | 0.2355 | |
| GSE77861 | PHACTR1 | 221692 | 232045_at | -0.0397 | 0.7418 | |
| GSE97050 | PHACTR1 | 221692 | A_32_P52018 | 0.0709 | 0.9268 | |
| SRP007169 | PHACTR1 | 221692 | RNAseq | -0.2028 | 0.7319 | |
| SRP064894 | PHACTR1 | 221692 | RNAseq | 0.4498 | 0.0356 | |
| SRP133303 | PHACTR1 | 221692 | RNAseq | -0.1042 | 0.6295 | |
| SRP159526 | PHACTR1 | 221692 | RNAseq | -0.0573 | 0.8499 | |
| SRP193095 | PHACTR1 | 221692 | RNAseq | 0.5657 | 0.0077 | |
| SRP219564 | PHACTR1 | 221692 | RNAseq | 0.0661 | 0.8126 | |
| TCGA | PHACTR1 | 221692 | RNAseq | -0.4840 | 0.0535 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PHACTR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHACTR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHACTR1 | 221692 | 3 | 7 | 20 | |
| GSE20123 | PHACTR1 | 221692 | 3 | 7 | 20 | |
| GSE43470 | PHACTR1 | 221692 | 8 | 1 | 34 | |
| GSE46452 | PHACTR1 | 221692 | 1 | 10 | 48 | |
| GSE47630 | PHACTR1 | 221692 | 7 | 8 | 25 | |
| GSE54993 | PHACTR1 | 221692 | 1 | 1 | 68 | |
| GSE54994 | PHACTR1 | 221692 | 10 | 3 | 40 | |
| GSE60625 | PHACTR1 | 221692 | 0 | 1 | 10 | |
| GSE74703 | PHACTR1 | 221692 | 7 | 1 | 28 | |
| GSE74704 | PHACTR1 | 221692 | 2 | 3 | 15 | |
| TCGA | PHACTR1 | 221692 | 16 | 26 | 54 |
Total number of gains: 58; Total number of losses: 68; Total Number of normals: 362.
Somatic mutations of PHACTR1:
Generating mutation plots.
Highly correlated genes for PHACTR1:
Showing top 20/364 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHACTR1 | FLI1 | 0.795162 | 4 | 0 | 4 |
| PHACTR1 | GIMAP1 | 0.789618 | 4 | 0 | 4 |
| PHACTR1 | C16orf54 | 0.787948 | 4 | 0 | 4 |
| PHACTR1 | RGS18 | 0.777411 | 4 | 0 | 4 |
| PHACTR1 | CST7 | 0.766688 | 4 | 0 | 4 |
| PHACTR1 | AKT1S1 | 0.76382 | 3 | 0 | 3 |
| PHACTR1 | FLYWCH2 | 0.763279 | 3 | 0 | 3 |
| PHACTR1 | ARHGAP9 | 0.759543 | 4 | 0 | 4 |
| PHACTR1 | GIMAP5 | 0.752855 | 3 | 0 | 3 |
| PHACTR1 | SNX20 | 0.749341 | 5 | 0 | 5 |
| PHACTR1 | GTPBP10 | 0.742483 | 3 | 0 | 3 |
| PHACTR1 | BTLA | 0.728445 | 4 | 0 | 4 |
| PHACTR1 | GIMAP4 | 0.721434 | 4 | 0 | 4 |
| PHACTR1 | NCKAP1L | 0.715737 | 5 | 0 | 5 |
| PHACTR1 | ZNF334 | 0.712209 | 3 | 0 | 3 |
| PHACTR1 | MPEG1 | 0.71134 | 5 | 0 | 5 |
| PHACTR1 | ARHGAP15 | 0.708975 | 3 | 0 | 3 |
| PHACTR1 | SMAP2 | 0.707822 | 5 | 0 | 4 |
| PHACTR1 | IRF8 | 0.704127 | 5 | 0 | 4 |
| PHACTR1 | AOAH | 0.703183 | 4 | 0 | 3 |
For details and further investigation, click here
