| Full name: nicotinamide nucleotide adenylyltransferase 1 | Alias Symbol: NMNAT|PNAT1 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 64802 | HGNC ID: HGNC:17877 | Ensembl Gene: ENSG00000173614 | OMIM ID: 608700 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of NMNAT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NMNAT1 | 64802 | 223692_at | -0.3333 | 0.6137 | |
| GSE26886 | NMNAT1 | 64802 | 1569631_at | -0.3353 | 0.1309 | |
| GSE45670 | NMNAT1 | 64802 | 1569631_at | 0.1351 | 0.3633 | |
| GSE53622 | NMNAT1 | 64802 | 129604 | -0.5066 | 0.0000 | |
| GSE53624 | NMNAT1 | 64802 | 129604 | -0.5290 | 0.0000 | |
| GSE63941 | NMNAT1 | 64802 | 223692_at | -0.3166 | 0.5941 | |
| GSE77861 | NMNAT1 | 64802 | 1569631_at | -0.2192 | 0.0867 | |
| GSE97050 | NMNAT1 | 64802 | A_33_P3215193 | -0.0450 | 0.8869 | |
| SRP007169 | NMNAT1 | 64802 | RNAseq | -1.3240 | 0.0018 | |
| SRP008496 | NMNAT1 | 64802 | RNAseq | -1.2529 | 0.0000 | |
| SRP064894 | NMNAT1 | 64802 | RNAseq | 0.0569 | 0.7449 | |
| SRP133303 | NMNAT1 | 64802 | RNAseq | -0.1855 | 0.1995 | |
| SRP159526 | NMNAT1 | 64802 | RNAseq | -0.5566 | 0.0521 | |
| SRP193095 | NMNAT1 | 64802 | RNAseq | -0.4183 | 0.0000 | |
| SRP219564 | NMNAT1 | 64802 | RNAseq | -0.5191 | 0.0866 | |
| TCGA | NMNAT1 | 64802 | RNAseq | -0.2676 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by NMNAT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NMNAT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NMNAT1 | 64802 | 0 | 5 | 25 | |
| GSE20123 | NMNAT1 | 64802 | 0 | 3 | 27 | |
| GSE43470 | NMNAT1 | 64802 | 6 | 5 | 32 | |
| GSE46452 | NMNAT1 | 64802 | 7 | 1 | 51 | |
| GSE47630 | NMNAT1 | 64802 | 8 | 4 | 28 | |
| GSE54993 | NMNAT1 | 64802 | 3 | 1 | 66 | |
| GSE54994 | NMNAT1 | 64802 | 12 | 4 | 37 | |
| GSE60625 | NMNAT1 | 64802 | 0 | 0 | 11 | |
| GSE74703 | NMNAT1 | 64802 | 5 | 3 | 28 | |
| GSE74704 | NMNAT1 | 64802 | 0 | 0 | 20 | |
| TCGA | NMNAT1 | 64802 | 10 | 24 | 62 |
Total number of gains: 51; Total number of losses: 50; Total Number of normals: 387.
Somatic mutations of NMNAT1:
Generating mutation plots.
Highly correlated genes for NMNAT1:
Showing top 20/519 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NMNAT1 | BAG5 | 0.740729 | 3 | 0 | 3 |
| NMNAT1 | SETD2 | 0.738521 | 3 | 0 | 3 |
| NMNAT1 | GAPVD1 | 0.71295 | 3 | 0 | 3 |
| NMNAT1 | BTBD7 | 0.709977 | 3 | 0 | 3 |
| NMNAT1 | RRAGC | 0.709483 | 3 | 0 | 3 |
| NMNAT1 | NANS | 0.708692 | 3 | 0 | 3 |
| NMNAT1 | ATG2B | 0.706421 | 3 | 0 | 3 |
| NMNAT1 | ELF2 | 0.705672 | 3 | 0 | 3 |
| NMNAT1 | KDM3B | 0.705503 | 3 | 0 | 3 |
| NMNAT1 | ARL16 | 0.704572 | 4 | 0 | 3 |
| NMNAT1 | GNL3 | 0.695716 | 3 | 0 | 3 |
| NMNAT1 | NDUFV2 | 0.695347 | 3 | 0 | 3 |
| NMNAT1 | EXOC1 | 0.695297 | 4 | 0 | 4 |
| NMNAT1 | ANAPC16 | 0.694349 | 4 | 0 | 4 |
| NMNAT1 | NDUFC1 | 0.692981 | 5 | 0 | 5 |
| NMNAT1 | PPA1 | 0.685961 | 3 | 0 | 3 |
| NMNAT1 | FAM149B1 | 0.685858 | 4 | 0 | 4 |
| NMNAT1 | PDE7B | 0.681635 | 3 | 0 | 3 |
| NMNAT1 | NAA30 | 0.68138 | 3 | 0 | 3 |
| NMNAT1 | HADH | 0.680995 | 3 | 0 | 3 |
For details and further investigation, click here
