| Full name: PDZ domain containing 1 | Alias Symbol: PDZD1|NHERF3 | ||
| Type: protein-coding gene | Cytoband: 1q21.1 | ||
| Entrez ID: 5174 | HGNC ID: HGNC:8821 | Ensembl Gene: ENSG00000174827 | OMIM ID: 603831 |
| Drug and gene relationship at DGIdb | |||
Expression of PDZK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDZK1 | 5174 | 205380_at | -0.0079 | 0.9789 | |
| GSE20347 | PDZK1 | 5174 | 205380_at | 0.0452 | 0.5781 | |
| GSE23400 | PDZK1 | 5174 | 205380_at | 0.0002 | 0.9918 | |
| GSE26886 | PDZK1 | 5174 | 205380_at | 0.1793 | 0.2393 | |
| GSE29001 | PDZK1 | 5174 | 205380_at | 0.3424 | 0.0855 | |
| GSE38129 | PDZK1 | 5174 | 205380_at | 0.0133 | 0.8455 | |
| GSE45670 | PDZK1 | 5174 | 205380_at | 0.3554 | 0.3312 | |
| GSE63941 | PDZK1 | 5174 | 205380_at | -0.6358 | 0.4395 | |
| GSE77861 | PDZK1 | 5174 | 205380_at | -0.0311 | 0.6749 | |
| GSE97050 | PDZK1 | 5174 | A_23_P52121 | -0.1416 | 0.5786 | |
| SRP133303 | PDZK1 | 5174 | RNAseq | -0.1889 | 0.4210 | |
| SRP159526 | PDZK1 | 5174 | RNAseq | 0.9143 | 0.0706 | |
| SRP193095 | PDZK1 | 5174 | RNAseq | 0.2374 | 0.2421 | |
| SRP219564 | PDZK1 | 5174 | RNAseq | 0.7381 | 0.1575 | |
| TCGA | PDZK1 | 5174 | RNAseq | -0.5500 | 0.0709 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PDZK1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PDZK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDZK1 | 5174 | 12 | 0 | 18 | |
| GSE20123 | PDZK1 | 5174 | 12 | 0 | 18 | |
| GSE43470 | PDZK1 | 5174 | 5 | 1 | 37 | |
| GSE46452 | PDZK1 | 5174 | 2 | 1 | 56 | |
| GSE47630 | PDZK1 | 5174 | 11 | 2 | 27 | |
| GSE54993 | PDZK1 | 5174 | 0 | 2 | 68 | |
| GSE54994 | PDZK1 | 5174 | 15 | 0 | 38 | |
| GSE60625 | PDZK1 | 5174 | 0 | 0 | 11 | |
| GSE74703 | PDZK1 | 5174 | 5 | 1 | 30 | |
| GSE74704 | PDZK1 | 5174 | 6 | 0 | 14 | |
| TCGA | PDZK1 | 5174 | 33 | 15 | 48 |
Total number of gains: 101; Total number of losses: 22; Total Number of normals: 365.
Somatic mutations of PDZK1:
Generating mutation plots.
Highly correlated genes for PDZK1:
Showing top 20/101 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDZK1 | FKBP2 | 0.740539 | 3 | 0 | 3 |
| PDZK1 | IL34 | 0.717054 | 3 | 0 | 3 |
| PDZK1 | NDUFC1 | 0.692965 | 3 | 0 | 3 |
| PDZK1 | UBE2E2 | 0.683805 | 3 | 0 | 3 |
| PDZK1 | MAPK8IP3 | 0.668211 | 3 | 0 | 3 |
| PDZK1 | TP53I11 | 0.664061 | 3 | 0 | 3 |
| PDZK1 | GPR132 | 0.661752 | 3 | 0 | 3 |
| PDZK1 | IPMK | 0.656041 | 3 | 0 | 3 |
| PDZK1 | DZANK1 | 0.65554 | 3 | 0 | 3 |
| PDZK1 | SRA1 | 0.654204 | 3 | 0 | 3 |
| PDZK1 | PHRF1 | 0.653881 | 4 | 0 | 4 |
| PDZK1 | DVL1 | 0.650989 | 4 | 0 | 3 |
| PDZK1 | TRMT61A | 0.649866 | 3 | 0 | 3 |
| PDZK1 | CCNJ | 0.647994 | 3 | 0 | 3 |
| PDZK1 | MAST1 | 0.646205 | 3 | 0 | 3 |
| PDZK1 | TCF15 | 0.64533 | 3 | 0 | 3 |
| PDZK1 | ZNF320 | 0.641957 | 3 | 0 | 3 |
| PDZK1 | ANKRD9 | 0.64099 | 4 | 0 | 4 |
| PDZK1 | UNC80 | 0.635816 | 3 | 0 | 3 |
| PDZK1 | ZNF287 | 0.635259 | 3 | 0 | 3 |
For details and further investigation, click here
