| Full name: NIMA related kinase 4 | Alias Symbol: NRK2|pp12301 | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 6787 | HGNC ID: HGNC:11399 | Ensembl Gene: ENSG00000114904 | OMIM ID: 601959 |
| Drug and gene relationship at DGIdb | |||
Expression of NEK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEK4 | 6787 | 204634_at | 0.1284 | 0.7834 | |
| GSE20347 | NEK4 | 6787 | 204634_at | -0.3212 | 0.1389 | |
| GSE23400 | NEK4 | 6787 | 204634_at | 0.1442 | 0.0277 | |
| GSE26886 | NEK4 | 6787 | 204634_at | -0.5259 | 0.0408 | |
| GSE29001 | NEK4 | 6787 | 204634_at | 0.0858 | 0.8524 | |
| GSE38129 | NEK4 | 6787 | 204634_at | -0.0856 | 0.6236 | |
| GSE45670 | NEK4 | 6787 | 204634_at | -0.0253 | 0.8566 | |
| GSE53622 | NEK4 | 6787 | 13431 | -0.3725 | 0.0000 | |
| GSE53624 | NEK4 | 6787 | 13431 | -0.3004 | 0.0140 | |
| GSE63941 | NEK4 | 6787 | 204634_at | -0.8650 | 0.0550 | |
| GSE77861 | NEK4 | 6787 | 1554659_at | -0.0322 | 0.7924 | |
| GSE97050 | NEK4 | 6787 | A_24_P80338 | -0.3654 | 0.1932 | |
| SRP007169 | NEK4 | 6787 | RNAseq | 0.9106 | 0.1291 | |
| SRP008496 | NEK4 | 6787 | RNAseq | 1.1073 | 0.0082 | |
| SRP064894 | NEK4 | 6787 | RNAseq | -0.3137 | 0.3577 | |
| SRP133303 | NEK4 | 6787 | RNAseq | -0.0113 | 0.9217 | |
| SRP159526 | NEK4 | 6787 | RNAseq | 0.1969 | 0.4151 | |
| SRP193095 | NEK4 | 6787 | RNAseq | -0.1408 | 0.2263 | |
| SRP219564 | NEK4 | 6787 | RNAseq | -0.3997 | 0.1742 | |
| TCGA | NEK4 | 6787 | RNAseq | -0.1726 | 0.0011 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NEK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEK4 | 6787 | 0 | 18 | 12 | |
| GSE20123 | NEK4 | 6787 | 0 | 19 | 11 | |
| GSE43470 | NEK4 | 6787 | 0 | 18 | 25 | |
| GSE46452 | NEK4 | 6787 | 2 | 17 | 40 | |
| GSE47630 | NEK4 | 6787 | 1 | 24 | 15 | |
| GSE54993 | NEK4 | 6787 | 6 | 2 | 62 | |
| GSE54994 | NEK4 | 6787 | 0 | 33 | 20 | |
| GSE60625 | NEK4 | 6787 | 5 | 0 | 6 | |
| GSE74703 | NEK4 | 6787 | 0 | 14 | 22 | |
| GSE74704 | NEK4 | 6787 | 0 | 12 | 8 | |
| TCGA | NEK4 | 6787 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 235; Total Number of normals: 239.
Somatic mutations of NEK4:
Generating mutation plots.
Highly correlated genes for NEK4:
Showing top 20/347 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEK4 | NFXL1 | 0.861181 | 3 | 0 | 3 |
| NEK4 | EXOC8 | 0.765704 | 3 | 0 | 3 |
| NEK4 | HNRNPAB | 0.765027 | 3 | 0 | 3 |
| NEK4 | NAA25 | 0.758719 | 3 | 0 | 3 |
| NEK4 | COX16 | 0.750613 | 3 | 0 | 3 |
| NEK4 | SDAD1 | 0.74647 | 3 | 0 | 3 |
| NEK4 | DNAJC13 | 0.740371 | 3 | 0 | 3 |
| NEK4 | SFPQ | 0.739327 | 4 | 0 | 4 |
| NEK4 | ZNF784 | 0.737857 | 3 | 0 | 3 |
| NEK4 | DPY19L3 | 0.735006 | 3 | 0 | 3 |
| NEK4 | PHF3 | 0.733501 | 3 | 0 | 3 |
| NEK4 | MIS18A | 0.727323 | 3 | 0 | 3 |
| NEK4 | ARFGEF2 | 0.725052 | 4 | 0 | 4 |
| NEK4 | FMR1 | 0.724052 | 3 | 0 | 3 |
| NEK4 | SNX4 | 0.721522 | 4 | 0 | 3 |
| NEK4 | LATS1 | 0.720976 | 4 | 0 | 3 |
| NEK4 | HSPA14 | 0.70498 | 3 | 0 | 3 |
| NEK4 | HERC4 | 0.698899 | 4 | 0 | 3 |
| NEK4 | STYX | 0.692409 | 4 | 0 | 3 |
| NEK4 | SRPK1 | 0.68659 | 4 | 0 | 4 |
For details and further investigation, click here
