| Full name: SRSF protein kinase 1 | Alias Symbol: SFRSK1 | ||
| Type: protein-coding gene | Cytoband: 6p21.31 | ||
| Entrez ID: 6732 | HGNC ID: HGNC:11305 | Ensembl Gene: ENSG00000096063 | OMIM ID: 601939 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SRPK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection |
Expression of SRPK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRPK1 | 6732 | 202200_s_at | 0.4976 | 0.2970 | |
| GSE20347 | SRPK1 | 6732 | 202200_s_at | 0.0007 | 0.9976 | |
| GSE23400 | SRPK1 | 6732 | 202199_s_at | -0.0130 | 0.8435 | |
| GSE26886 | SRPK1 | 6732 | 202200_s_at | -0.0569 | 0.8048 | |
| GSE29001 | SRPK1 | 6732 | 202200_s_at | -0.0856 | 0.7565 | |
| GSE38129 | SRPK1 | 6732 | 202200_s_at | 0.2121 | 0.2325 | |
| GSE45670 | SRPK1 | 6732 | 202200_s_at | 0.1139 | 0.4353 | |
| GSE53622 | SRPK1 | 6732 | 24606 | -0.1315 | 0.0853 | |
| GSE53624 | SRPK1 | 6732 | 24606 | -0.0147 | 0.8020 | |
| GSE63941 | SRPK1 | 6732 | 202200_s_at | 0.6254 | 0.0587 | |
| GSE77861 | SRPK1 | 6732 | 202200_s_at | 0.0687 | 0.8712 | |
| GSE97050 | SRPK1 | 6732 | A_23_P19543 | 0.0606 | 0.8524 | |
| SRP007169 | SRPK1 | 6732 | RNAseq | -0.9071 | 0.0336 | |
| SRP008496 | SRPK1 | 6732 | RNAseq | -0.7091 | 0.0015 | |
| SRP064894 | SRPK1 | 6732 | RNAseq | -0.1768 | 0.4701 | |
| SRP133303 | SRPK1 | 6732 | RNAseq | 0.0374 | 0.8169 | |
| SRP159526 | SRPK1 | 6732 | RNAseq | 0.1122 | 0.6513 | |
| SRP193095 | SRPK1 | 6732 | RNAseq | -0.1674 | 0.1215 | |
| SRP219564 | SRPK1 | 6732 | RNAseq | 0.2167 | 0.6614 | |
| TCGA | SRPK1 | 6732 | RNAseq | 0.1650 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRPK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRPK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRPK1 | 6732 | 5 | 0 | 25 | |
| GSE20123 | SRPK1 | 6732 | 5 | 0 | 25 | |
| GSE43470 | SRPK1 | 6732 | 5 | 1 | 37 | |
| GSE46452 | SRPK1 | 6732 | 2 | 9 | 48 | |
| GSE47630 | SRPK1 | 6732 | 8 | 4 | 28 | |
| GSE54993 | SRPK1 | 6732 | 3 | 1 | 66 | |
| GSE54994 | SRPK1 | 6732 | 11 | 4 | 38 | |
| GSE60625 | SRPK1 | 6732 | 1 | 0 | 10 | |
| GSE74703 | SRPK1 | 6732 | 5 | 0 | 31 | |
| GSE74704 | SRPK1 | 6732 | 2 | 0 | 18 | |
| TCGA | SRPK1 | 6732 | 15 | 15 | 66 |
Total number of gains: 62; Total number of losses: 34; Total Number of normals: 392.
Somatic mutations of SRPK1:
Generating mutation plots.
Highly correlated genes for SRPK1:
Showing top 20/533 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRPK1 | UNC5CL | 0.814189 | 3 | 0 | 3 |
| SRPK1 | PRRC2C | 0.782801 | 3 | 0 | 3 |
| SRPK1 | MDM2 | 0.77567 | 3 | 0 | 3 |
| SRPK1 | TBL2 | 0.770618 | 3 | 0 | 3 |
| SRPK1 | PUSL1 | 0.765179 | 3 | 0 | 3 |
| SRPK1 | ABCF1 | 0.762094 | 3 | 0 | 3 |
| SRPK1 | PHF6 | 0.754628 | 3 | 0 | 3 |
| SRPK1 | TRAP1 | 0.746544 | 4 | 0 | 4 |
| SRPK1 | LSM6 | 0.743776 | 3 | 0 | 3 |
| SRPK1 | TRUB1 | 0.73697 | 3 | 0 | 3 |
| SRPK1 | PEX10 | 0.72466 | 3 | 0 | 3 |
| SRPK1 | PMPCB | 0.717908 | 3 | 0 | 3 |
| SRPK1 | SEC22A | 0.715307 | 4 | 0 | 4 |
| SRPK1 | OGFOD1 | 0.71174 | 3 | 0 | 3 |
| SRPK1 | RBBP6 | 0.707799 | 3 | 0 | 3 |
| SRPK1 | CDC73 | 0.705026 | 4 | 0 | 4 |
| SRPK1 | ETV6 | 0.703791 | 3 | 0 | 3 |
| SRPK1 | FAM185A | 0.703435 | 3 | 0 | 3 |
| SRPK1 | MAP4K3 | 0.702819 | 3 | 0 | 3 |
| SRPK1 | MGA | 0.702576 | 4 | 0 | 3 |
For details and further investigation, click here
