NFKBIB

 

Full name: NFKB inhibitor beta Alias Symbol: IKBB|TRIP9
Type: protein-coding gene Cytoband: 19q13.1
Entrez ID: 4793 HGNC ID: HGNC:7798 Ensembl Gene: ENSG00000104825 OMIM ID: 604495
Drug and gene relationship at DGIdb

 

NFKBIB involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05131Shigellosis
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection

 

Expression of NFKBIB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NFKBIB 4793 214448_x_at 0.1060 0.7339
GSE20347 NFKBIB 4793 214062_x_at -0.0394 0.7117
GSE23400 NFKBIB 4793 214062_x_at -0.0999 0.0243
GSE26886 NFKBIB 4793 214062_x_at 0.5101 0.0038
GSE29001 NFKBIB 4793 214062_x_at -0.0057 0.9773
GSE38129 NFKBIB 4793 214062_x_at 0.0619 0.4914
GSE45670 NFKBIB 4793 214062_x_at 0.2354 0.0217
GSE53622 NFKBIB 4793 23726 -0.4211 0.0000
GSE53624 NFKBIB 4793 23726 -0.4176 0.0000
GSE63941 NFKBIB 4793 214448_x_at 0.7357 0.0119
GSE77861 NFKBIB 4793 214062_x_at 0.0475 0.7657
GSE97050 NFKBIB 4793 A_33_P3343545 -0.2299 0.6704
SRP007169 NFKBIB 4793 RNAseq -0.0115 0.9848
SRP008496 NFKBIB 4793 RNAseq -0.1534 0.7261
SRP064894 NFKBIB 4793 RNAseq 0.5157 0.0360
SRP133303 NFKBIB 4793 RNAseq 0.4127 0.1174
SRP159526 NFKBIB 4793 RNAseq 0.0208 0.9302
SRP193095 NFKBIB 4793 RNAseq -0.0289 0.7936
SRP219564 NFKBIB 4793 RNAseq 0.0102 0.9677
TCGA NFKBIB 4793 RNAseq 0.0924 0.1056

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NFKBIB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NFKBIB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NFKBIB 4793 7 4 19
GSE20123 NFKBIB 4793 7 3 20
GSE43470 NFKBIB 4793 4 10 29
GSE46452 NFKBIB 4793 47 2 10
GSE47630 NFKBIB 4793 9 5 26
GSE54993 NFKBIB 4793 17 3 50
GSE54994 NFKBIB 4793 6 9 38
GSE60625 NFKBIB 4793 9 0 2
GSE74703 NFKBIB 4793 4 6 26
GSE74704 NFKBIB 4793 7 1 12
TCGA NFKBIB 4793 14 16 66

Total number of gains: 131; Total number of losses: 59; Total Number of normals: 298.  

 

Somatic mutations of NFKBIB:

 

Generating mutation plots.

 

Highly correlated genes for NFKBIB:

 

Showing top 20/259 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NFKBIBINO80B0.701035303
NFKBIBIQCC0.688739303
NFKBIBGGT50.688728303
NFKBIBNAA600.68813404
NFKBIBADAP10.685897303
NFKBIBRAD23A0.678327303
NFKBIBCASKIN20.673479403
NFKBIBC9orf160.671958403
NFKBIBCCDC1300.671872404
NFKBIBTBC1D250.667609303
NFKBIBPPP2R5D0.667335303
NFKBIBC1orf1590.666712403
NFKBIBGAS6-AS10.665035303
NFKBIBBIRC70.664252303
NFKBIBMAPK40.658722403
NFKBIBTSPAN150.658402303
NFKBIBSMG60.651329303
NFKBIBEGR40.649106404
NFKBIBCRYBB20.647146303
NFKBIBKXD10.643607403

For details and further investigation, click here