| Full name: SMG6 nonsense mediated mRNA decay factor | Alias Symbol: KIAA0732|SMG-6|EST1A | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 23293 | HGNC ID: HGNC:17809 | Ensembl Gene: ENSG00000070366 | OMIM ID: 610963 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SMG6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMG6 | 23293 | 214940_s_at | -0.0094 | 0.9799 | |
| GSE20347 | SMG6 | 23293 | 214940_s_at | -0.1285 | 0.1683 | |
| GSE23400 | SMG6 | 23293 | 214940_s_at | -0.0433 | 0.3338 | |
| GSE26886 | SMG6 | 23293 | 214940_s_at | 0.5403 | 0.0000 | |
| GSE29001 | SMG6 | 23293 | 214940_s_at | -0.0534 | 0.8219 | |
| GSE38129 | SMG6 | 23293 | 214940_s_at | -0.1795 | 0.0823 | |
| GSE45670 | SMG6 | 23293 | 214940_s_at | -0.0244 | 0.8339 | |
| GSE63941 | SMG6 | 23293 | 214940_s_at | -0.3423 | 0.1332 | |
| GSE77861 | SMG6 | 23293 | 214940_s_at | 0.1131 | 0.5475 | |
| GSE97050 | SMG6 | 23293 | A_23_P100676 | -0.4052 | 0.1403 | |
| SRP007169 | SMG6 | 23293 | RNAseq | 0.7918 | 0.0459 | |
| SRP008496 | SMG6 | 23293 | RNAseq | 0.7733 | 0.0225 | |
| SRP064894 | SMG6 | 23293 | RNAseq | 0.1089 | 0.3605 | |
| SRP133303 | SMG6 | 23293 | RNAseq | -0.3679 | 0.0062 | |
| SRP159526 | SMG6 | 23293 | RNAseq | -0.0430 | 0.8651 | |
| SRP193095 | SMG6 | 23293 | RNAseq | 0.1677 | 0.1801 | |
| SRP219564 | SMG6 | 23293 | RNAseq | 0.0024 | 0.9942 | |
| TCGA | SMG6 | 23293 | RNAseq | -0.0662 | 0.1487 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SMG6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SMG6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMG6 | 23293 | 4 | 2 | 24 | |
| GSE20123 | SMG6 | 23293 | 4 | 3 | 23 | |
| GSE43470 | SMG6 | 23293 | 1 | 6 | 36 | |
| GSE46452 | SMG6 | 23293 | 34 | 1 | 24 | |
| GSE47630 | SMG6 | 23293 | 7 | 1 | 32 | |
| GSE54993 | SMG6 | 23293 | 4 | 3 | 63 | |
| GSE54994 | SMG6 | 23293 | 7 | 9 | 37 | |
| GSE60625 | SMG6 | 23293 | 4 | 0 | 7 | |
| GSE74703 | SMG6 | 23293 | 1 | 3 | 32 | |
| GSE74704 | SMG6 | 23293 | 2 | 1 | 17 | |
| TCGA | SMG6 | 23293 | 18 | 22 | 56 |
Total number of gains: 86; Total number of losses: 51; Total Number of normals: 351.
Somatic mutations of SMG6:
Generating mutation plots.
Highly correlated genes for SMG6:
Showing top 20/385 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMG6 | FOXN3 | 0.715481 | 3 | 0 | 3 |
| SMG6 | PPP2R5B | 0.714808 | 3 | 0 | 3 |
| SMG6 | GTPBP1 | 0.710277 | 4 | 0 | 4 |
| SMG6 | GADD45G | 0.708923 | 4 | 0 | 4 |
| SMG6 | DMBT1 | 0.704484 | 3 | 0 | 3 |
| SMG6 | ADARB1 | 0.699418 | 5 | 0 | 5 |
| SMG6 | MLLT6 | 0.680865 | 3 | 0 | 3 |
| SMG6 | TECPR2 | 0.680232 | 6 | 0 | 6 |
| SMG6 | ADCY9 | 0.677965 | 3 | 0 | 3 |
| SMG6 | HID1 | 0.666636 | 3 | 0 | 3 |
| SMG6 | GRASP | 0.664729 | 4 | 0 | 4 |
| SMG6 | PLP1 | 0.655877 | 3 | 0 | 3 |
| SMG6 | FRZB | 0.655122 | 3 | 0 | 3 |
| SMG6 | NCSTN | 0.654004 | 3 | 0 | 3 |
| SMG6 | STAT6 | 0.652795 | 4 | 0 | 3 |
| SMG6 | NFKBIB | 0.651329 | 3 | 0 | 3 |
| SMG6 | DCAF8 | 0.650559 | 3 | 0 | 3 |
| SMG6 | WFS1 | 0.64957 | 4 | 0 | 3 |
| SMG6 | LAMB2 | 0.649261 | 4 | 0 | 3 |
| SMG6 | PRRT2 | 0.646329 | 3 | 0 | 3 |
For details and further investigation, click here
