| Full name: PTC7 protein phosphatase homolog | Alias Symbol: TA-PP2C | ||
| Type: protein-coding gene | Cytoband: 12q24.11 | ||
| Entrez ID: 160760 | HGNC ID: HGNC:30695 | Ensembl Gene: ENSG00000196850 | OMIM ID: 609668 |
| Drug and gene relationship at DGIdb | |||
Expression of PPTC7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPTC7 | 160760 | 225204_at | 0.4588 | 0.4133 | |
| GSE26886 | PPTC7 | 160760 | 225213_at | 0.4632 | 0.0949 | |
| GSE45670 | PPTC7 | 160760 | 225213_at | 0.0008 | 0.9974 | |
| GSE53622 | PPTC7 | 160760 | 35408 | 0.2956 | 0.0001 | |
| GSE53624 | PPTC7 | 160760 | 35408 | 0.0655 | 0.2779 | |
| GSE63941 | PPTC7 | 160760 | 225204_at | 1.3162 | 0.0128 | |
| GSE77861 | PPTC7 | 160760 | 225204_at | 0.5860 | 0.0105 | |
| GSE97050 | PPTC7 | 160760 | A_23_P306933 | -0.2985 | 0.1978 | |
| SRP007169 | PPTC7 | 160760 | RNAseq | 0.3422 | 0.3747 | |
| SRP008496 | PPTC7 | 160760 | RNAseq | 0.3856 | 0.2035 | |
| SRP064894 | PPTC7 | 160760 | RNAseq | -0.3953 | 0.1630 | |
| SRP133303 | PPTC7 | 160760 | RNAseq | 0.3982 | 0.0259 | |
| SRP159526 | PPTC7 | 160760 | RNAseq | 0.0682 | 0.8630 | |
| SRP193095 | PPTC7 | 160760 | RNAseq | 0.2747 | 0.0302 | |
| SRP219564 | PPTC7 | 160760 | RNAseq | -0.0570 | 0.8776 | |
| TCGA | PPTC7 | 160760 | RNAseq | 0.0603 | 0.3685 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PPTC7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPTC7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPTC7 | 160760 | 5 | 3 | 22 | |
| GSE20123 | PPTC7 | 160760 | 5 | 3 | 22 | |
| GSE43470 | PPTC7 | 160760 | 2 | 1 | 40 | |
| GSE46452 | PPTC7 | 160760 | 9 | 1 | 49 | |
| GSE47630 | PPTC7 | 160760 | 9 | 3 | 28 | |
| GSE54993 | PPTC7 | 160760 | 0 | 5 | 65 | |
| GSE54994 | PPTC7 | 160760 | 5 | 3 | 45 | |
| GSE60625 | PPTC7 | 160760 | 0 | 0 | 11 | |
| GSE74703 | PPTC7 | 160760 | 2 | 0 | 34 | |
| GSE74704 | PPTC7 | 160760 | 2 | 2 | 16 | |
| TCGA | PPTC7 | 160760 | 22 | 11 | 63 |
Total number of gains: 61; Total number of losses: 32; Total Number of normals: 395.
Somatic mutations of PPTC7:
Generating mutation plots.
Highly correlated genes for PPTC7:
Showing top 20/497 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPTC7 | PIGC | 0.786867 | 3 | 0 | 3 |
| PPTC7 | MRPL16 | 0.784248 | 3 | 0 | 3 |
| PPTC7 | DHX35 | 0.780876 | 3 | 0 | 3 |
| PPTC7 | ZDHHC17 | 0.780251 | 3 | 0 | 3 |
| PPTC7 | CSNK2A2 | 0.776474 | 3 | 0 | 3 |
| PPTC7 | RAD21 | 0.77563 | 3 | 0 | 3 |
| PPTC7 | RNF139 | 0.772441 | 3 | 0 | 3 |
| PPTC7 | QSOX2 | 0.770722 | 3 | 0 | 3 |
| PPTC7 | ZZZ3 | 0.761193 | 3 | 0 | 3 |
| PPTC7 | GLG1 | 0.757609 | 3 | 0 | 3 |
| PPTC7 | ARPP19 | 0.753068 | 3 | 0 | 3 |
| PPTC7 | C18orf54 | 0.746493 | 3 | 0 | 3 |
| PPTC7 | TOMM20 | 0.746389 | 3 | 0 | 3 |
| PPTC7 | HTATSF1 | 0.744262 | 3 | 0 | 3 |
| PPTC7 | MSH6 | 0.742023 | 3 | 0 | 3 |
| PPTC7 | KIAA1586 | 0.741761 | 3 | 0 | 3 |
| PPTC7 | MRPS5 | 0.738203 | 3 | 0 | 3 |
| PPTC7 | HAUS6 | 0.733922 | 3 | 0 | 3 |
| PPTC7 | MED1 | 0.733561 | 4 | 0 | 4 |
| PPTC7 | NAP1L1 | 0.731725 | 3 | 0 | 3 |
For details and further investigation, click here
