RUVBL1

 

Full name: RuvB like AAA ATPase 1 Alias Symbol: TIP49|NMP238|RVB1|TIP49a|Pontin52|ECP54|TIH1|Rvb1|INO80H
Type: protein-coding gene Cytoband: 3q21.3
Entrez ID: 8607 HGNC ID: HGNC:10474 Ensembl Gene: ENSG00000175792 OMIM ID: 603449
Drug and gene relationship at DGIdb

 

RUVBL1 involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway

 

Expression of RUVBL1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RUVBL1 8607 201614_s_at 1.2480 0.0086
GSE20347 RUVBL1 8607 201614_s_at 1.4442 0.0000
GSE23400 RUVBL1 8607 201614_s_at 1.0535 0.0000
GSE26886 RUVBL1 8607 201614_s_at 0.8749 0.0000
GSE29001 RUVBL1 8607 201614_s_at 1.2906 0.0086
GSE38129 RUVBL1 8607 201614_s_at 1.4691 0.0000
GSE45670 RUVBL1 8607 201614_s_at 1.1609 0.0000
GSE53622 RUVBL1 8607 54640 1.3100 0.0000
GSE53624 RUVBL1 8607 54640 1.4844 0.0000
GSE63941 RUVBL1 8607 201614_s_at 1.5011 0.0011
GSE77861 RUVBL1 8607 201614_s_at 1.0569 0.0004
GSE97050 RUVBL1 8607 A_24_P148811 1.1166 0.1061
SRP007169 RUVBL1 8607 RNAseq 2.8489 0.0000
SRP008496 RUVBL1 8607 RNAseq 3.3277 0.0000
SRP064894 RUVBL1 8607 RNAseq 1.5057 0.0000
SRP133303 RUVBL1 8607 RNAseq 1.2430 0.0000
SRP159526 RUVBL1 8607 RNAseq 1.3063 0.0000
SRP193095 RUVBL1 8607 RNAseq 1.0984 0.0000
SRP219564 RUVBL1 8607 RNAseq 0.8567 0.0479
TCGA RUVBL1 8607 RNAseq 0.5381 0.0000

Upregulated datasets: 16; Downregulated datasets: 0.  

 

Survival by RUVBL1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RUVBL1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RUVBL1 8607 17 0 13
GSE20123 RUVBL1 8607 17 0 13
GSE43470 RUVBL1 8607 19 0 24
GSE46452 RUVBL1 8607 14 5 40
GSE47630 RUVBL1 8607 17 4 19
GSE54993 RUVBL1 8607 2 7 61
GSE54994 RUVBL1 8607 31 3 19
GSE60625 RUVBL1 8607 0 6 5
GSE74703 RUVBL1 8607 17 0 19
GSE74704 RUVBL1 8607 13 0 7
TCGA RUVBL1 8607 57 5 34

Total number of gains: 204; Total number of losses: 30; Total Number of normals: 254.  

 

Somatic mutations of RUVBL1:

 

Generating mutation plots.

 

Highly correlated genes for RUVBL1:

 

Showing top 20/2087 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RUVBL1CMSS10.833613707
RUVBL1CKS1B0.82010213013
RUVBL1UMPS0.81978712012
RUVBL1GMPS0.80748913013
RUVBL1DKC10.80242303
RUVBL1MEST0.79504210010
RUVBL1MYBL20.79302412012
RUVBL1PRKDC0.79020611011
RUVBL1MCM20.78734213012
RUVBL1PSME40.78157311011
RUVBL1MCM70.78075411011
RUVBL1UBE2C0.77956212011
RUVBL1UBE2T0.778994908
RUVBL1CAD0.77755812012
RUVBL1ECT20.77586812011
RUVBL1RFC40.77581213012
RUVBL1ACTL6A0.77463313012
RUVBL1DDX39A0.77288212012
RUVBL1ILF20.77279512012
RUVBL1PBK0.77150911011

For details and further investigation, click here