AHSA1

 

Full name: activator of HSP90 ATPase activity 1 Alias Symbol: p38|Aha1|hAha1
Type: protein-coding gene Cytoband: 14q24.3
Entrez ID: 10598 HGNC ID: HGNC:1189 Ensembl Gene: ENSG00000100591 OMIM ID: 608466
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of AHSA1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 AHSA1 10598 201491_at 0.5489 0.1659
GSE20347 AHSA1 10598 201491_at 0.7052 0.0000
GSE23400 AHSA1 10598 201491_at 0.8906 0.0000
GSE26886 AHSA1 10598 201491_at 0.4110 0.0173
GSE29001 AHSA1 10598 201491_at 0.9157 0.0348
GSE38129 AHSA1 10598 201491_at 0.7494 0.0000
GSE45670 AHSA1 10598 201491_at 0.6787 0.0096
GSE53622 AHSA1 10598 61235 0.8563 0.0000
GSE53624 AHSA1 10598 61235 0.8570 0.0000
GSE63941 AHSA1 10598 201491_at 0.3146 0.4488
GSE77861 AHSA1 10598 201491_at 0.5033 0.0586
GSE97050 AHSA1 10598 A_23_P117599 0.1780 0.6756
SRP007169 AHSA1 10598 RNAseq 0.6638 0.0513
SRP008496 AHSA1 10598 RNAseq 0.7462 0.0003
SRP064894 AHSA1 10598 RNAseq 0.8443 0.0000
SRP133303 AHSA1 10598 RNAseq 0.8464 0.0000
SRP159526 AHSA1 10598 RNAseq 0.7641 0.0333
SRP193095 AHSA1 10598 RNAseq 0.5553 0.0003
SRP219564 AHSA1 10598 RNAseq 0.3085 0.5029
TCGA AHSA1 10598 RNAseq 0.1967 0.0001

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by AHSA1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of AHSA1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 AHSA1 10598 8 3 19
GSE20123 AHSA1 10598 8 3 19
GSE43470 AHSA1 10598 8 3 32
GSE46452 AHSA1 10598 16 3 40
GSE47630 AHSA1 10598 11 8 21
GSE54993 AHSA1 10598 3 8 59
GSE54994 AHSA1 10598 19 4 30
GSE60625 AHSA1 10598 0 2 9
GSE74703 AHSA1 10598 7 3 26
GSE74704 AHSA1 10598 3 3 14
TCGA AHSA1 10598 32 16 48

Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.  

 

Somatic mutations of AHSA1:

 

Generating mutation plots.

 

Highly correlated genes for AHSA1:

 

Showing top 20/1553 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
AHSA1CCT30.74476411010
AHSA1NOP560.722581303
AHSA1PFDN20.71823811010
AHSA1ERH0.70655112010
AHSA1STRIP20.706496404
AHSA1PUF600.70544212011
AHSA1SLC38A60.700618807
AHSA1LONP10.69564610010
AHSA1HSP90AA10.69188511010
AHSA1IFT430.690436707
AHSA1CKS1B0.69013711010
AHSA1BMS10.689643606
AHSA1SERPINH10.68952611010
AHSA1PSMC10.688411008
AHSA1G2E30.686355605
AHSA1MNAT10.68439512010
AHSA1EIF3B0.6831911009
AHSA1MRGBP0.68024907
AHSA1ATP6V1C10.67966111010
AHSA1SH3PXD2B0.677086606

For details and further investigation, click here