FAM49B

 

Full name: family with sequence similarity 49 member B Alias Symbol: BM-009
Type: protein-coding gene Cytoband: 8q24.21
Entrez ID: 51571 HGNC ID: HGNC:25216 Ensembl Gene: ENSG00000153310 OMIM ID: 617978
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of FAM49B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FAM49B 51571 217916_s_at 0.7685 0.1201
GSE20347 FAM49B 51571 217916_s_at 0.5296 0.0001
GSE23400 FAM49B 51571 217916_s_at 0.6635 0.0000
GSE26886 FAM49B 51571 217916_s_at 0.3341 0.0297
GSE29001 FAM49B 51571 217916_s_at 0.3784 0.0922
GSE38129 FAM49B 51571 217916_s_at 0.8012 0.0000
GSE45670 FAM49B 51571 217916_s_at 0.6725 0.0001
GSE53622 FAM49B 51571 147261 0.7397 0.0000
GSE53624 FAM49B 51571 147261 0.7219 0.0000
GSE63941 FAM49B 51571 217916_s_at 1.6859 0.0004
GSE77861 FAM49B 51571 217916_s_at 0.2704 0.1199
GSE97050 FAM49B 51571 A_23_P43255 0.7823 0.1198
SRP007169 FAM49B 51571 RNAseq 0.0844 0.7743
SRP008496 FAM49B 51571 RNAseq 0.1695 0.3152
SRP064894 FAM49B 51571 RNAseq 0.9201 0.0000
SRP133303 FAM49B 51571 RNAseq 0.8438 0.0000
SRP159526 FAM49B 51571 RNAseq 0.4297 0.2056
SRP193095 FAM49B 51571 RNAseq 0.5591 0.0000
SRP219564 FAM49B 51571 RNAseq 0.5908 0.2297
TCGA FAM49B 51571 RNAseq 0.4903 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by FAM49B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FAM49B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FAM49B 51571 17 0 13
GSE20123 FAM49B 51571 17 0 13
GSE43470 FAM49B 51571 22 0 21
GSE46452 FAM49B 51571 27 0 32
GSE47630 FAM49B 51571 24 0 16
GSE54993 FAM49B 51571 0 24 46
GSE54994 FAM49B 51571 39 1 13
GSE60625 FAM49B 51571 0 7 4
GSE74703 FAM49B 51571 19 0 17
GSE74704 FAM49B 51571 11 0 9
TCGA FAM49B 51571 67 3 26

Total number of gains: 243; Total number of losses: 35; Total Number of normals: 210.  

 

Somatic mutations of FAM49B:

 

Generating mutation plots.

 

Highly correlated genes for FAM49B:

 

Showing top 20/1669 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FAM49BCCDC85C0.807937303
FAM49BRLIM0.767006303
FAM49BDKC10.752678303
FAM49BZNF7070.750845303
FAM49BFAM89A0.729037303
FAM49BNCOA60.725863303
FAM49BNIPBL0.724542303
FAM49BNEK60.720011404
FAM49BSCD0.717735303
FAM49BGART0.71285611010
FAM49BTPM30.712693605
FAM49BTBC1D20.708713303
FAM49BNUF20.707394807
FAM49BATAD20.70686113012
FAM49BMMS22L0.705232303
FAM49BTTYH30.703708606
FAM49BNAP1L40.702964403
FAM49BTMEM132A0.702823706
FAM49BPRKDC0.70082810010
FAM49BCDH30.70001410010

For details and further investigation, click here