| Full name: tRNA methyltransferase 61A | Alias Symbol: FLJ40452|GCD14|Gcd14p|hTRM61 | ||
| Type: protein-coding gene | Cytoband: 14q32 | ||
| Entrez ID: 115708 | HGNC ID: HGNC:23790 | Ensembl Gene: ENSG00000166166 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TRMT61A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRMT61A | 115708 | 221907_at | 0.5132 | 0.2312 | |
| GSE20347 | TRMT61A | 115708 | 221907_at | 0.4084 | 0.0000 | |
| GSE23400 | TRMT61A | 115708 | 221907_at | 0.1114 | 0.0389 | |
| GSE26886 | TRMT61A | 115708 | 221907_at | 0.3980 | 0.0015 | |
| GSE29001 | TRMT61A | 115708 | 221907_at | 0.3112 | 0.1067 | |
| GSE38129 | TRMT61A | 115708 | 221907_at | 0.1406 | 0.2450 | |
| GSE45670 | TRMT61A | 115708 | 221907_at | 0.1588 | 0.0611 | |
| GSE53622 | TRMT61A | 115708 | 39072 | 0.2359 | 0.0033 | |
| GSE53624 | TRMT61A | 115708 | 39072 | -0.4387 | 0.0000 | |
| GSE63941 | TRMT61A | 115708 | 221907_at | -0.1962 | 0.3640 | |
| GSE77861 | TRMT61A | 115708 | 221907_at | 0.0090 | 0.9609 | |
| GSE97050 | TRMT61A | 115708 | A_24_P373126 | 0.1907 | 0.3898 | |
| SRP007169 | TRMT61A | 115708 | RNAseq | 1.6193 | 0.0018 | |
| SRP008496 | TRMT61A | 115708 | RNAseq | 1.4317 | 0.0001 | |
| SRP064894 | TRMT61A | 115708 | RNAseq | 1.0464 | 0.0016 | |
| SRP133303 | TRMT61A | 115708 | RNAseq | 0.5261 | 0.0135 | |
| SRP159526 | TRMT61A | 115708 | RNAseq | 0.8283 | 0.0952 | |
| SRP193095 | TRMT61A | 115708 | RNAseq | 0.7711 | 0.0000 | |
| SRP219564 | TRMT61A | 115708 | RNAseq | 0.4366 | 0.3681 | |
| TCGA | TRMT61A | 115708 | RNAseq | 0.0812 | 0.1968 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by TRMT61A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRMT61A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRMT61A | 115708 | 12 | 3 | 15 | |
| GSE20123 | TRMT61A | 115708 | 11 | 2 | 17 | |
| GSE43470 | TRMT61A | 115708 | 6 | 4 | 33 | |
| GSE46452 | TRMT61A | 115708 | 18 | 4 | 37 | |
| GSE47630 | TRMT61A | 115708 | 10 | 8 | 22 | |
| GSE54993 | TRMT61A | 115708 | 3 | 8 | 59 | |
| GSE54994 | TRMT61A | 115708 | 21 | 4 | 28 | |
| GSE60625 | TRMT61A | 115708 | 0 | 2 | 9 | |
| GSE74703 | TRMT61A | 115708 | 5 | 3 | 28 | |
| GSE74704 | TRMT61A | 115708 | 5 | 2 | 13 | |
| TCGA | TRMT61A | 115708 | 31 | 20 | 45 |
Total number of gains: 122; Total number of losses: 60; Total Number of normals: 306.
Somatic mutations of TRMT61A:
Generating mutation plots.
Highly correlated genes for TRMT61A:
Showing top 20/676 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRMT61A | ACY1 | 0.829153 | 3 | 0 | 3 |
| TRMT61A | MSTO1 | 0.823898 | 3 | 0 | 3 |
| TRMT61A | ALKBH6 | 0.798869 | 3 | 0 | 3 |
| TRMT61A | NUP43 | 0.794221 | 3 | 0 | 3 |
| TRMT61A | CRTC2 | 0.765505 | 3 | 0 | 3 |
| TRMT61A | ZMYND19 | 0.760346 | 3 | 0 | 3 |
| TRMT61A | ZNF579 | 0.754732 | 4 | 0 | 4 |
| TRMT61A | ROMO1 | 0.752819 | 3 | 0 | 3 |
| TRMT61A | CCAR1 | 0.744223 | 3 | 0 | 3 |
| TRMT61A | LHX5 | 0.740026 | 4 | 0 | 4 |
| TRMT61A | NACC1 | 0.738202 | 3 | 0 | 3 |
| TRMT61A | PDGFRB | 0.735507 | 3 | 0 | 3 |
| TRMT61A | C12orf45 | 0.73253 | 3 | 0 | 3 |
| TRMT61A | TSNARE1 | 0.731806 | 3 | 0 | 3 |
| TRMT61A | SYMPK | 0.728764 | 3 | 0 | 3 |
| TRMT61A | ZNF683 | 0.728143 | 4 | 0 | 4 |
| TRMT61A | RRP36 | 0.725068 | 3 | 0 | 3 |
| TRMT61A | APOC2 | 0.724134 | 3 | 0 | 3 |
| TRMT61A | KLHDC3 | 0.723288 | 3 | 0 | 3 |
| TRMT61A | SSC5D | 0.722423 | 3 | 0 | 3 |
For details and further investigation, click here
