| Full name: integrator complex subunit 1 | Alias Symbol: DKFZp586J0619|KIAA1440|INT1|NET28 | ||
| Type: protein-coding gene | Cytoband: 7p22.3 | ||
| Entrez ID: 26173 | HGNC ID: HGNC:24555 | Ensembl Gene: ENSG00000164880 | OMIM ID: 611345 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of INTS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INTS1 | 26173 | 212212_s_at | 0.8035 | 0.0107 | |
| GSE20347 | INTS1 | 26173 | 212212_s_at | 0.4239 | 0.0001 | |
| GSE23400 | INTS1 | 26173 | 212212_s_at | 0.3265 | 0.0000 | |
| GSE26886 | INTS1 | 26173 | 212212_s_at | 0.9801 | 0.0000 | |
| GSE29001 | INTS1 | 26173 | 212212_s_at | 0.3040 | 0.0676 | |
| GSE38129 | INTS1 | 26173 | 212212_s_at | 0.3770 | 0.0000 | |
| GSE45670 | INTS1 | 26173 | 212212_s_at | 0.4000 | 0.0001 | |
| GSE53622 | INTS1 | 26173 | 85041 | 0.0366 | 0.4225 | |
| GSE53624 | INTS1 | 26173 | 85041 | -0.2400 | 0.0006 | |
| GSE63941 | INTS1 | 26173 | 212212_s_at | -0.0165 | 0.9664 | |
| GSE77861 | INTS1 | 26173 | 212212_s_at | 0.0796 | 0.7402 | |
| GSE97050 | INTS1 | 26173 | A_33_P3316045 | -0.0234 | 0.9494 | |
| SRP007169 | INTS1 | 26173 | RNAseq | 1.0066 | 0.0711 | |
| SRP008496 | INTS1 | 26173 | RNAseq | 0.5429 | 0.1024 | |
| SRP064894 | INTS1 | 26173 | RNAseq | 0.8868 | 0.0000 | |
| SRP133303 | INTS1 | 26173 | RNAseq | 0.3968 | 0.0293 | |
| SRP159526 | INTS1 | 26173 | RNAseq | 0.5612 | 0.1361 | |
| SRP193095 | INTS1 | 26173 | RNAseq | 0.6269 | 0.0000 | |
| SRP219564 | INTS1 | 26173 | RNAseq | 0.3820 | 0.2258 | |
| TCGA | INTS1 | 26173 | RNAseq | 0.0339 | 0.4293 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by INTS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INTS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INTS1 | 26173 | 14 | 0 | 16 | |
| GSE20123 | INTS1 | 26173 | 14 | 0 | 16 | |
| GSE43470 | INTS1 | 26173 | 6 | 2 | 35 | |
| GSE46452 | INTS1 | 26173 | 13 | 1 | 45 | |
| GSE47630 | INTS1 | 26173 | 10 | 1 | 29 | |
| GSE54993 | INTS1 | 26173 | 0 | 7 | 63 | |
| GSE54994 | INTS1 | 26173 | 19 | 2 | 32 | |
| GSE60625 | INTS1 | 26173 | 0 | 0 | 11 | |
| GSE74703 | INTS1 | 26173 | 6 | 1 | 29 | |
| GSE74704 | INTS1 | 26173 | 9 | 0 | 11 | |
| TCGA | INTS1 | 26173 | 57 | 5 | 34 |
Total number of gains: 148; Total number of losses: 19; Total Number of normals: 321.
Somatic mutations of INTS1:
Generating mutation plots.
Highly correlated genes for INTS1:
Showing top 20/1155 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INTS1 | ROMO1 | 0.87274 | 3 | 0 | 3 |
| INTS1 | MIF | 0.822074 | 3 | 0 | 3 |
| INTS1 | LEMD2 | 0.82122 | 3 | 0 | 3 |
| INTS1 | ZBTB9 | 0.795914 | 3 | 0 | 3 |
| INTS1 | SLC39A3 | 0.778119 | 5 | 0 | 5 |
| INTS1 | ZNF683 | 0.769015 | 4 | 0 | 4 |
| INTS1 | UBTD1 | 0.768194 | 3 | 0 | 3 |
| INTS1 | PTGFRN | 0.767168 | 3 | 0 | 3 |
| INTS1 | PPP1R9B | 0.765264 | 4 | 0 | 4 |
| INTS1 | RAVER1 | 0.764541 | 3 | 0 | 3 |
| INTS1 | AGTRAP | 0.761363 | 4 | 0 | 4 |
| INTS1 | ZNF579 | 0.757553 | 4 | 0 | 4 |
| INTS1 | EFTUD2 | 0.756058 | 4 | 0 | 4 |
| INTS1 | ACY1 | 0.754977 | 3 | 0 | 3 |
| INTS1 | WDR81 | 0.753328 | 3 | 0 | 3 |
| INTS1 | SSBP4 | 0.747226 | 4 | 0 | 4 |
| INTS1 | TDG | 0.743976 | 3 | 0 | 3 |
| INTS1 | MAPRE3 | 0.743917 | 3 | 0 | 3 |
| INTS1 | MATN4 | 0.743572 | 3 | 0 | 3 |
| INTS1 | GPR158 | 0.740841 | 4 | 0 | 4 |
For details and further investigation, click here
