| Full name: cyclin dependent kinase inhibitor 2D | Alias Symbol: INK4D|p19 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 1032 | HGNC ID: HGNC:1790 | Ensembl Gene: ENSG00000129355 | OMIM ID: 600927 |
| Drug and gene relationship at DGIdb | |||
CDKN2D involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04110 | Cell cycle |
Expression of CDKN2D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDKN2D | 1032 | 210240_s_at | 0.2135 | 0.6282 | |
| GSE20347 | CDKN2D | 1032 | 210240_s_at | -0.0095 | 0.9082 | |
| GSE23400 | CDKN2D | 1032 | 210240_s_at | -0.0739 | 0.0825 | |
| GSE26886 | CDKN2D | 1032 | 210240_s_at | 0.4598 | 0.0041 | |
| GSE29001 | CDKN2D | 1032 | 210240_s_at | -0.1439 | 0.3762 | |
| GSE38129 | CDKN2D | 1032 | 210240_s_at | 0.0756 | 0.5910 | |
| GSE45670 | CDKN2D | 1032 | 210240_s_at | 0.2481 | 0.1532 | |
| GSE53622 | CDKN2D | 1032 | 33556 | -0.0088 | 0.9482 | |
| GSE53624 | CDKN2D | 1032 | 33556 | 0.3394 | 0.0000 | |
| GSE63941 | CDKN2D | 1032 | 210240_s_at | 0.6866 | 0.1141 | |
| GSE77861 | CDKN2D | 1032 | 210240_s_at | 0.1844 | 0.3200 | |
| GSE97050 | CDKN2D | 1032 | A_23_P89941 | 0.1845 | 0.5940 | |
| SRP007169 | CDKN2D | 1032 | RNAseq | -0.3045 | 0.5440 | |
| SRP008496 | CDKN2D | 1032 | RNAseq | 0.1555 | 0.6953 | |
| SRP064894 | CDKN2D | 1032 | RNAseq | 0.5593 | 0.0118 | |
| SRP133303 | CDKN2D | 1032 | RNAseq | 0.7349 | 0.0082 | |
| SRP159526 | CDKN2D | 1032 | RNAseq | 0.3673 | 0.1812 | |
| SRP193095 | CDKN2D | 1032 | RNAseq | 0.6616 | 0.0000 | |
| SRP219564 | CDKN2D | 1032 | RNAseq | 0.3463 | 0.3221 | |
| TCGA | CDKN2D | 1032 | RNAseq | 0.4619 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDKN2D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDKN2D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDKN2D | 1032 | 4 | 3 | 23 | |
| GSE20123 | CDKN2D | 1032 | 3 | 1 | 26 | |
| GSE43470 | CDKN2D | 1032 | 3 | 6 | 34 | |
| GSE46452 | CDKN2D | 1032 | 47 | 1 | 11 | |
| GSE47630 | CDKN2D | 1032 | 4 | 7 | 29 | |
| GSE54993 | CDKN2D | 1032 | 16 | 3 | 51 | |
| GSE54994 | CDKN2D | 1032 | 6 | 13 | 34 | |
| GSE60625 | CDKN2D | 1032 | 9 | 0 | 2 | |
| GSE74703 | CDKN2D | 1032 | 3 | 4 | 29 | |
| GSE74704 | CDKN2D | 1032 | 0 | 1 | 19 | |
| TCGA | CDKN2D | 1032 | 15 | 14 | 67 |
Total number of gains: 110; Total number of losses: 53; Total Number of normals: 325.
Somatic mutations of CDKN2D:
Generating mutation plots.
Highly correlated genes for CDKN2D:
Showing top 20/379 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDKN2D | ZNF594 | 0.773585 | 3 | 0 | 3 |
| CDKN2D | RIMKLA | 0.762834 | 3 | 0 | 3 |
| CDKN2D | AGK | 0.749324 | 3 | 0 | 3 |
| CDKN2D | POFUT1 | 0.748867 | 3 | 0 | 3 |
| CDKN2D | EMG1 | 0.734642 | 3 | 0 | 3 |
| CDKN2D | SRA1 | 0.733915 | 3 | 0 | 3 |
| CDKN2D | CATSPER1 | 0.728244 | 3 | 0 | 3 |
| CDKN2D | KIAA1257 | 0.724411 | 3 | 0 | 3 |
| CDKN2D | MED9 | 0.724352 | 3 | 0 | 3 |
| CDKN2D | BRAT1 | 0.715433 | 3 | 0 | 3 |
| CDKN2D | SLC38A1 | 0.71043 | 3 | 0 | 3 |
| CDKN2D | ADAD2 | 0.709428 | 3 | 0 | 3 |
| CDKN2D | HRH1 | 0.707496 | 3 | 0 | 3 |
| CDKN2D | VPS39 | 0.705703 | 3 | 0 | 3 |
| CDKN2D | MLST8 | 0.704225 | 3 | 0 | 3 |
| CDKN2D | RBM33 | 0.702121 | 3 | 0 | 3 |
| CDKN2D | MED22 | 0.694836 | 4 | 0 | 3 |
| CDKN2D | LARP1 | 0.694576 | 3 | 0 | 3 |
| CDKN2D | PPP1R16A | 0.692897 | 4 | 0 | 3 |
| CDKN2D | ITGB8 | 0.692712 | 3 | 0 | 3 |
For details and further investigation, click here
