| Full name: dicarbonyl and L-xylulose reductase | Alias Symbol: KIDCR|DCR|SDR20C1 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 51181 | HGNC ID: HGNC:18985 | Ensembl Gene: ENSG00000169738 | OMIM ID: 608347 |
| Drug and gene relationship at DGIdb | |||
Expression of DCXR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DCXR | 51181 | 217973_at | 0.1228 | 0.8001 | |
| GSE20347 | DCXR | 51181 | 217973_at | -0.6343 | 0.0005 | |
| GSE23400 | DCXR | 51181 | 217973_at | -0.2439 | 0.0184 | |
| GSE26886 | DCXR | 51181 | 217973_at | -0.5238 | 0.0027 | |
| GSE29001 | DCXR | 51181 | 217973_at | -0.6508 | 0.0213 | |
| GSE38129 | DCXR | 51181 | 217973_at | -0.3676 | 0.0258 | |
| GSE45670 | DCXR | 51181 | 217973_at | -0.4219 | 0.0641 | |
| GSE53622 | DCXR | 51181 | 17528 | -0.3901 | 0.0001 | |
| GSE53624 | DCXR | 51181 | 17528 | -0.3463 | 0.0000 | |
| GSE63941 | DCXR | 51181 | 217973_at | 2.5377 | 0.0003 | |
| GSE77861 | DCXR | 51181 | 217973_at | -0.9707 | 0.0137 | |
| GSE97050 | DCXR | 51181 | A_23_P44166 | 0.3214 | 0.3084 | |
| SRP007169 | DCXR | 51181 | RNAseq | -1.3553 | 0.0027 | |
| SRP008496 | DCXR | 51181 | RNAseq | -1.3567 | 0.0000 | |
| SRP064894 | DCXR | 51181 | RNAseq | -0.2598 | 0.4546 | |
| SRP133303 | DCXR | 51181 | RNAseq | -0.4783 | 0.0093 | |
| SRP159526 | DCXR | 51181 | RNAseq | -0.0116 | 0.9650 | |
| SRP193095 | DCXR | 51181 | RNAseq | -0.7917 | 0.0000 | |
| SRP219564 | DCXR | 51181 | RNAseq | 0.0941 | 0.8445 | |
| TCGA | DCXR | 51181 | RNAseq | -0.2447 | 0.0010 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by DCXR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DCXR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DCXR | 51181 | 4 | 4 | 22 | |
| GSE20123 | DCXR | 51181 | 4 | 4 | 22 | |
| GSE43470 | DCXR | 51181 | 3 | 5 | 35 | |
| GSE46452 | DCXR | 51181 | 34 | 0 | 25 | |
| GSE47630 | DCXR | 51181 | 9 | 2 | 29 | |
| GSE54993 | DCXR | 51181 | 2 | 5 | 63 | |
| GSE54994 | DCXR | 51181 | 10 | 6 | 37 | |
| GSE60625 | DCXR | 51181 | 6 | 0 | 5 | |
| GSE74703 | DCXR | 51181 | 3 | 3 | 30 | |
| GSE74704 | DCXR | 51181 | 4 | 3 | 13 | |
| TCGA | DCXR | 51181 | 24 | 13 | 59 |
Total number of gains: 103; Total number of losses: 45; Total Number of normals: 340.
Somatic mutations of DCXR:
Generating mutation plots.
Highly correlated genes for DCXR:
Showing top 20/774 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DCXR | TDP1 | 0.766531 | 3 | 0 | 3 |
| DCXR | NOTCH3 | 0.755876 | 3 | 0 | 3 |
| DCXR | EEFSEC | 0.744109 | 3 | 0 | 3 |
| DCXR | PRPF38A | 0.740453 | 3 | 0 | 3 |
| DCXR | AP1G2 | 0.728076 | 3 | 0 | 3 |
| DCXR | VCP | 0.727621 | 3 | 0 | 3 |
| DCXR | RAC3 | 0.721628 | 3 | 0 | 3 |
| DCXR | POLN | 0.717439 | 3 | 0 | 3 |
| DCXR | SMDT1 | 0.715928 | 3 | 0 | 3 |
| DCXR | ARFRP1 | 0.709175 | 3 | 0 | 3 |
| DCXR | ZNF174 | 0.709129 | 3 | 0 | 3 |
| DCXR | C1orf159 | 0.709013 | 3 | 0 | 3 |
| DCXR | PRKCSH | 0.708519 | 3 | 0 | 3 |
| DCXR | CNOT10 | 0.70848 | 4 | 0 | 4 |
| DCXR | TRMT5 | 0.704557 | 3 | 0 | 3 |
| DCXR | RAB40AL | 0.703999 | 3 | 0 | 3 |
| DCXR | IRX3 | 0.702327 | 4 | 0 | 3 |
| DCXR | CD19 | 0.699803 | 3 | 0 | 3 |
| DCXR | MCU | 0.698779 | 3 | 0 | 3 |
| DCXR | KLHDC3 | 0.695976 | 4 | 0 | 4 |
For details and further investigation, click here
